ENSG00000180891

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000407144 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding protein_coding 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 1.566900 2.002089 2.1311248 0.1703176 0.25165019 0.08967440 0.10841250 0.07823333 0.18200000 0.10376667 0.003439324 0.003439324 FALSE TRUE
ENST00000577830 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding protein_coding 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 6.279151 9.980746 1.0835195 2.2995482 0.62980169 -3.19161336 0.27910000 0.37103333 0.09303333 -0.27800000 0.412112103 0.003439324 FALSE TRUE
ENST00000577840 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding protein_coding 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 1.379570 1.285528 1.2459287 0.7451618 0.65232324 -0.04478546 0.07487500 0.05886667 0.10426667 0.04540000 0.955867500 0.003439324 FALSE TRUE
ENST00000578357 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding processed_transcript 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 2.939504 3.267630 1.5503994 1.6348039 0.20299196 -1.07073776 0.13931250 0.11283333 0.13216667 0.01933333 0.913601286 0.003439324   FALSE
ENST00000582951 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding retained_intron 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 1.209822 2.062279 0.7797078 0.1833911 0.24123188 -1.39182760 0.06684583 0.08040000 0.06636667 -0.01403333 0.881319807 0.003439324   FALSE
ENST00000584746 ENSG00000180891 HEK293_OSMI2_6hA HEK293_TMG_6hB CUEDC1 protein_coding retained_intron 19.40705 26.11272 11.64973 3.329913 0.4776696 -1.163772 3.535698 4.457325 2.7428396 0.3614794 0.05420276 -0.69849057 0.19648333 0.17943333 0.23610000 0.05666667 0.694583820 0.003439324 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180891 E001 4.4228205 0.0100186237 0.542669977 0.73099366 17 57861243 57861603 361 - 0.545 0.683 0.609
ENSG00000180891 E002 321.6757006 1.1050724120 0.413793149 0.63883750 17 57861604 57862695 1092 - 2.260 2.449 0.631
ENSG00000180891 E003 128.4390574 0.4861413261 0.284977939 0.52556154 17 57862696 57862874 179 - 1.858 2.054 0.657
ENSG00000180891 E004 56.0236834 0.2160329879 0.309531749 0.55002208 17 57862875 57862914 40 - 1.535 1.695 0.544
ENSG00000180891 E005 62.2103037 0.2503061044 0.264093271 0.50335168 17 57862915 57862962 48 - 1.567 1.741 0.589
ENSG00000180891 E006 44.7383414 0.1715814232 0.220083820 0.45362221 17 57862963 57862975 13 - 1.419 1.603 0.630
ENSG00000180891 E007 180.7498900 0.9201751068 0.490974935 0.69465576 17 57862976 57863271 296 - 2.081 2.187 0.356
ENSG00000180891 E008 65.5159142 0.3196968017 0.451182305 0.66649095 17 57863272 57863285 14 - 1.662 1.749 0.293
ENSG00000180891 E009 2.7511093 0.0082030920 0.865652944 0.93351905 17 57863286 57863357 72 - 0.460 0.522 0.305
ENSG00000180891 E010 111.0046520 0.0003985689 0.339994697 0.57794981 17 57866474 57866544 71 - 1.960 1.967 0.022
ENSG00000180891 E011 63.4544162 0.0582707019 0.010652267 0.06090244 17 57866545 57867240 696 - 1.906 1.653 -0.856
ENSG00000180891 E012 21.2107110 0.0651296553 0.063316023 0.21017430 17 57867241 57867356 116 - 1.424 1.202 -0.775
ENSG00000180891 E013 88.6350752 0.0007328094 0.280862232 0.52110638 17 57867357 57867415 59 - 1.868 1.864 -0.013
ENSG00000180891 E014 22.2357292 0.1460674871 0.332012904 0.57086420 17 57867416 57867630 215 - 1.393 1.243 -0.523
ENSG00000180891 E015 118.1580561 0.0366468038 0.219221732 0.45246038 17 57868150 57868243 94 - 2.032 1.971 -0.205
ENSG00000180891 E016 3.0238197 0.1592750379 0.316459228 0.55647423 17 57868244 57868465 222 - 0.682 0.494 -0.845
ENSG00000180891 E017 89.4932379 0.0103254146 0.110718628 0.30017223 17 57869122 57869193 72 - 1.907 1.856 -0.173
ENSG00000180891 E018 2.4887528 0.0469812169 0.545551924 0.73309883 17 57869897 57869938 42 - 0.353 0.501 0.788
ENSG00000180891 E019 83.5499367 0.0146521539 0.049100319 0.17744219 17 57871286 57871369 84 - 1.904 1.819 -0.285
ENSG00000180891 E020 122.5416611 0.0259859323 0.326763778 0.56593183 17 57872663 57872810 148 - 2.018 1.996 -0.073
ENSG00000180891 E021 83.1086691 0.0050920923 0.155121534 0.36962024 17 57872811 57872855 45 - 1.860 1.829 -0.105
ENSG00000180891 E022 116.6786692 0.0006106092 0.043308774 0.16335708 17 57873591 57873717 127 - 2.014 1.981 -0.110
ENSG00000180891 E023 95.8903479 0.0010421582 0.139558598 0.34682461 17 57879611 57879738 128 - 1.920 1.900 -0.064
ENSG00000180891 E024 1.0587795 0.0148262772 0.028511951   17 57885172 57885228 57 - 0.545 0.175 -2.334
ENSG00000180891 E025 80.1845966 0.0006437401 0.959391928 0.98160970 17 57885229 57885441 213 - 1.787 1.835 0.164
ENSG00000180891 E026 64.9010566 0.0290236101 0.236952281 0.47305496 17 57885442 57885645 204 - 1.579 1.760 0.615
ENSG00000180891 E027 50.8981985 0.0364505185 0.219340152 0.45261362 17 57885646 57885811 166 - 1.455 1.661 0.704
ENSG00000180891 E028 24.1147020 0.0151793916 0.005801432 0.03875112 17 57885812 57885879 68 - 0.990 1.375 1.370
ENSG00000180891 E029 0.4349185 0.0225974107 0.073801448   17 57892500 57892688 189 - 0.353 0.067 -2.919
ENSG00000180891 E030 0.0000000       17 57902986 57903389 404 -      
ENSG00000180891 E031 11.8055496 0.1086154646 0.122081500 0.31913930 17 57955225 57955415 191 - 0.678 1.089 1.582