ENSG00000180776

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000382466 ENSG00000180776 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC20 protein_coding protein_coding 13.97727 1.167375 27.8952 0.1102689 0.5630155 4.566888 5.1422467 0.5328386 9.474475 0.2043466 0.9413129 4.126973 0.36865417 0.4361667 0.33893333 -0.09723333 0.8752435283 0.0005655374 FALSE TRUE
ENST00000400590 ENSG00000180776 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC20 protein_coding protein_coding 13.97727 1.167375 27.8952 0.1102689 0.5630155 4.566888 1.9203306 0.3193984 1.843316 0.2526872 0.3366352 2.492204 0.13184167 0.2723000 0.06576667 -0.20653333 0.8334790726 0.0005655374 FALSE TRUE
ENST00000494731 ENSG00000180776 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC20 protein_coding processed_transcript 13.97727 1.167375 27.8952 0.1102689 0.5630155 4.566888 2.6026520 0.0000000 7.535759 0.0000000 2.2895010 9.559522 0.09767917 0.0000000 0.27190000 0.27190000 0.0005655374 0.0005655374 FALSE TRUE
ENST00000542645 ENSG00000180776 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC20 protein_coding protein_coding 13.97727 1.167375 27.8952 0.1102689 0.5630155 4.566888 2.2953687 0.3151379 4.746237 0.1642037 1.4859401 3.870697 0.16578333 0.2915333 0.16966667 -0.12186667 0.9680416398 0.0005655374 FALSE TRUE
ENST00000626464 ENSG00000180776 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC20 protein_coding nonsense_mediated_decay 13.97727 1.167375 27.8952 0.1102689 0.5630155 4.566888 0.8580571 0.0000000 2.523176 0.0000000 0.4749889 7.984803 0.15465417 0.0000000 0.08993333 0.08993333 0.0089771206 0.0005655374   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180776 E001 0.4349185 0.022617878 0.14988940   13 21372571 21372572 2 - 0.062 0.370 3.126
ENSG00000180776 E002 0.4349185 0.022617878 0.14988940   13 21372573 21372576 4 - 0.062 0.370 3.126
ENSG00000180776 E003 118.3091923 1.189650150 0.23799316 0.47428550 13 21372577 21373193 617 - 1.694 2.180 1.632
ENSG00000180776 E004 252.0721380 1.501469117 0.42072754 0.64423217 13 21373194 21374270 1077 - 2.041 2.351 1.036
ENSG00000180776 E005 149.8576538 1.292430502 0.38346739 0.61513217 13 21374271 21375106 836 - 1.817 2.140 1.086
ENSG00000180776 E006 245.0977458 1.504456770 0.59489379 0.76697673 13 21375107 21376346 1240 - 2.044 2.194 0.502
ENSG00000180776 E007 55.0466504 0.752938422 0.54766807 0.73460314 13 21376347 21376486 140 - 1.409 1.547 0.473
ENSG00000180776 E008 37.0756772 0.625818831 0.58962736 0.76346258 13 21376487 21376514 28 - 1.248 1.346 0.343
ENSG00000180776 E009 32.2106843 0.572191186 0.45667569 0.67078836 13 21376515 21376518 4 - 1.184 1.371 0.656
ENSG00000180776 E010 63.8550685 0.777634645 0.54648882 0.73382703 13 21376519 21376655 137 - 1.473 1.591 0.405
ENSG00000180776 E011 6.3378853 0.026526457 0.32484393 0.56406313 13 21378661 21378700 40 - 0.583 0.886 1.246
ENSG00000180776 E012 7.6130185 0.008586855 0.25920415 0.49810266 13 21378701 21378738 38 - 0.642 0.958 1.254
ENSG00000180776 E013 65.5259336 0.001163513 0.11944273 0.31495624 13 21381434 21381546 113 - 1.502 1.505 0.013
ENSG00000180776 E014 23.8087799 0.048257832 0.18274100 0.40759355 13 21381547 21381549 3 - 1.080 1.019 -0.223
ENSG00000180776 E015 3.1421251 0.016376588 0.16463287 0.38355022 13 21381901 21381945 45 - 0.405 0.001 -10.262
ENSG00000180776 E016 0.4820342 0.021768165 1.00000000   13 21381946 21381994 49 - 0.090 0.001 -7.527
ENSG00000180776 E017 70.3181005 0.079166124 0.13771239 0.34402877 13 21382920 21383009 90 - 1.523 1.484 -0.135
ENSG00000180776 E018 93.1602396 0.199324153 0.25370010 0.49203559 13 21387508 21387634 127 - 1.641 1.611 -0.105
ENSG00000180776 E019 0.1426347 0.032649190 0.47510888   13 21390195 21390254 60 - 0.032 0.001 -5.940
ENSG00000180776 E020 82.6653327 0.249612783 0.23907807 0.47554483 13 21391722 21391854 133 - 1.592 1.536 -0.193
ENSG00000180776 E021 65.4159405 0.189362663 0.08404416 0.25286805 13 21400373 21400493 121 - 1.499 1.333 -0.575
ENSG00000180776 E022 41.2476155 0.117714388 0.01858395 0.09101605 13 21401653 21401685 33 - 1.311 1.010 -1.078
ENSG00000180776 E023 53.4939994 0.109135173 0.02017135 0.09648920 13 21402797 21402866 70 - 1.418 1.156 -0.919
ENSG00000180776 E024 74.4380350 0.150189095 0.03003469 0.12745398 13 21413652 21413772 121 - 1.556 1.298 -0.890
ENSG00000180776 E025 56.3898981 0.144945061 0.08961221 0.26308607 13 21421061 21421164 104 - 1.436 1.268 -0.582
ENSG00000180776 E026 23.4464794 0.094552572 0.36981415 0.60384314 13 21425652 21425678 27 - 1.069 1.074 0.017
ENSG00000180776 E027 37.8949671 0.085157801 0.89519631 0.94932509 13 21459054 21459370 317 - 1.249 1.465 0.751