ENSG00000180488

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370791 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding protein_coding 10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 0.7152641 0.49967481 1.6587062 0.06870444 1.1921878 1.71108101 0.1121542 0.1319000 0.09233333 -0.03956667 7.870012e-01 1.954471e-12 FALSE TRUE
ENST00000443751 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding protein_coding 10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 1.3848310 0.24428858 2.6480947 0.03379474 0.8121622 3.38585394 0.1129417 0.0646000 0.14553333 0.08093333 5.761002e-01 1.954471e-12 FALSE TRUE
ENST00000643143 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding nonsense_mediated_decay 10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 0.7848557 0.00000000 0.9479841 0.00000000 0.5746360 6.58192985 0.0471625 0.0000000 0.05380000 0.05380000 5.763023e-01 1.954471e-12 TRUE TRUE
MSTRG.1452.5 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding   10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 1.6668750 0.08185648 4.6962413 0.08185648 1.0677574 5.67904992 0.1034875 0.0215000 0.25630000 0.23480000 5.752860e-02 1.954471e-12 FALSE TRUE
MSTRG.1452.6 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding   10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 1.5515520 0.00000000 3.6058305 0.00000000 0.3306012 8.49818323 0.0945875 0.0000000 0.19960000 0.19960000 1.747481e-11 1.954471e-12 FALSE TRUE
MSTRG.1452.9 ENSG00000180488 HEK293_OSMI2_6hA HEK293_TMG_6hB MIGA1 protein_coding   10.01963 3.788773 18.13248 0.1846909 0.5472799 2.255767 2.8637239 2.83522653 2.9780783 0.16076201 0.6758831 0.07067443 0.4438542 0.7477333 0.16243333 -0.58530000 1.954471e-12 1.954471e-12 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180488 E001 0.0000000       1 77779624 77779629 6 +      
ENSG00000180488 E002 0.0000000       1 77779630 77779632 3 +      
ENSG00000180488 E003 0.1779838 0.0332772558 6.128977e-01   1 77779633 77779633 1 + 0.042 0.001 -6.294
ENSG00000180488 E004 0.6765862 0.1838315868 1.000000e+00   1 77779634 77779635 2 + 0.150 0.000 -9.607
ENSG00000180488 E005 2.6448577 0.0174089699 7.134326e-01 8.440015e-01 1 77779636 77779648 13 + 0.386 0.483 0.507
ENSG00000180488 E006 8.1465711 0.0153014097 7.013924e-01 8.365057e-01 1 77779649 77779659 11 + 0.757 0.706 -0.208
ENSG00000180488 E007 32.6869467 0.0010997334 1.863587e-04 2.522154e-03 1 77779660 77779736 77 + 1.255 1.587 1.149
ENSG00000180488 E008 0.0000000       1 77779763 77779774 12 +      
ENSG00000180488 E009 0.6787990 0.0451314709 1.000000e+00   1 77779775 77779903 129 + 0.149 0.000 -10.097
ENSG00000180488 E010 0.4842470 0.7526491277 1.000000e+00   1 77779904 77779967 64 + 0.117 0.000 -8.726
ENSG00000180488 E011 1.2917014 0.0151313244 7.928869e-01   1 77779968 77780192 225 + 0.235 0.305 0.503
ENSG00000180488 E012 22.1772999 0.0017885805 1.081036e-07 3.974556e-06 1 77783238 77783242 5 + 1.058 1.564 1.771
ENSG00000180488 E013 33.5288044 0.0011700878 8.269388e-07 2.405502e-05 1 77783243 77783267 25 + 1.250 1.661 1.415
ENSG00000180488 E014 51.7822770 0.0008117955 3.993873e-05 6.866979e-04 1 77783268 77783351 84 + 1.455 1.756 1.024
ENSG00000180488 E015 13.3261446 0.3019604830 3.432967e-05 6.052707e-04 1 77788008 77788194 187 + 0.636 1.717 3.941
ENSG00000180488 E016 67.5551354 0.0007162044 1.565966e-04 2.178562e-03 1 77801331 77801508 178 + 1.626 1.329 -1.019
ENSG00000180488 E017 51.2360132 0.0008696703 1.368968e-04 1.943974e-03 1 77803270 77803388 119 + 1.513 1.153 -1.257
ENSG00000180488 E018 29.8730381 0.0022591167 3.041948e-02 1.286112e-01 1 77803389 77803406 18 + 1.285 1.048 -0.847
ENSG00000180488 E019 52.6951469 0.0009051845 1.732381e-02 8.663656e-02 1 77806975 77807101 127 + 1.517 1.329 -0.649
ENSG00000180488 E020 47.6654524 0.0009484327 1.607920e-01 3.779664e-01 1 77813734 77813867 134 + 1.469 1.369 -0.345
ENSG00000180488 E021 43.8979756 0.0010136631 3.473581e-01 5.848424e-01 1 77815108 77815231 124 + 1.429 1.369 -0.209
ENSG00000180488 E022 50.3255844 0.0010521962 1.061620e-01 2.926365e-01 1 77843307 77843407 101 + 1.487 1.369 -0.407
ENSG00000180488 E023 61.1334026 0.0006296124 2.871139e-03 2.263418e-02 1 77858938 77859056 119 + 1.579 1.349 -0.790
ENSG00000180488 E024 1.7832892 0.0115643592 2.930038e-01 5.336978e-01 1 77859057 77859313 257 + 0.328 0.000 -11.725
ENSG00000180488 E025 35.4372472 0.0010457588 7.444233e-02 2.336701e-01 1 77859314 77859386 73 + 1.348 1.183 -0.580
ENSG00000180488 E026 5.3709610 0.0076898343 3.230894e-01 5.623609e-01 1 77859387 77860039 653 + 0.587 0.785 0.830
ENSG00000180488 E027 43.5846491 0.0017081176 4.083887e-02 1.569055e-01 1 77860040 77860126 87 + 1.437 1.262 -0.610
ENSG00000180488 E028 8.5017676 0.0035394812 1.050304e-01 2.906967e-01 1 77860127 77861223 1097 + 0.794 0.482 -1.359
ENSG00000180488 E029 47.0742310 0.0014399293 1.867761e-03 1.618062e-02 1 77861224 77861322 99 + 1.474 1.183 -1.014
ENSG00000180488 E030 1.2812902 0.0216264265 7.895302e-01   1 77861323 77862215 893 + 0.235 0.305 0.507
ENSG00000180488 E031 54.1290312 0.0050000595 1.758956e-01 3.983241e-01 1 77863894 77864028 135 + 1.518 1.422 -0.331
ENSG00000180488 E032 42.8181485 0.0056279558 9.025585e-01 9.531276e-01 1 77866338 77866391 54 + 1.409 1.422 0.045
ENSG00000180488 E033 1.5539852 0.0120019669 1.186055e-02 6.585587e-02 1 77868248 77868636 389 + 0.208 0.705 2.727
ENSG00000180488 E034 10.6009774 0.0031892109 5.355910e-01 7.260139e-01 1 77873001 77873003 3 + 0.866 0.784 -0.318
ENSG00000180488 E035 52.9198568 0.0025812939 6.216319e-01 7.849110e-01 1 77873004 77873120 117 + 1.500 1.484 -0.055
ENSG00000180488 E036 216.1102382 0.0007521018 4.349223e-01 6.549334e-01 1 77874846 77876163 1318 + 2.103 2.097 -0.018
ENSG00000180488 E037 127.4393027 0.0023794217 7.403595e-01 8.606323e-01 1 77876164 77877052 889 + 1.876 1.883 0.022
ENSG00000180488 E038 225.5196427 0.0002597782 8.745563e-01 9.384840e-01 1 77877053 77878755 1703 + 2.118 2.138 0.065
ENSG00000180488 E039 40.8433641 0.0241547191 1.538327e-03 1.387378e-02 1 77878756 77879540 785 + 1.343 1.685 1.172