ENSG00000180398

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319466 ENSG00000180398 HEK293_OSMI2_6hA HEK293_TMG_6hB MCFD2 protein_coding protein_coding 51.42785 19.73367 66.82335 1.313886 1.166411 1.759178 35.565791 11.808572 51.3736080 1.0889214 1.21237631 2.1202524 0.67544167 0.59696667 0.768866667 0.17190000 2.429758e-03 6.574022e-07 FALSE TRUE
ENST00000409913 ENSG00000180398 HEK293_OSMI2_6hA HEK293_TMG_6hB MCFD2 protein_coding protein_coding 51.42785 19.73367 66.82335 1.313886 1.166411 1.759178 4.280981 2.723500 6.0339194 0.5084379 0.70843964 1.1447349 0.09250417 0.13643333 0.090100000 -0.04633333 4.699889e-01 6.574022e-07 FALSE FALSE
ENST00000434262 ENSG00000180398 HEK293_OSMI2_6hA HEK293_TMG_6hB MCFD2 protein_coding protein_coding 51.42785 19.73367 66.82335 1.313886 1.166411 1.759178 1.837044 1.469202 1.0474667 0.3470664 0.27229259 -0.4842068 0.04727917 0.07756667 0.015600000 -0.06196667 1.650470e-02 6.574022e-07 FALSE TRUE
MSTRG.18342.1 ENSG00000180398 HEK293_OSMI2_6hA HEK293_TMG_6hB MCFD2 protein_coding   51.42785 19.73367 66.82335 1.313886 1.166411 1.759178 3.264761 1.755645 0.5317635 0.5387300 0.05197597 -1.7044605 0.07033750 0.08706667 0.007966667 -0.07910000 6.574022e-07 6.574022e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180398 E001 3.6080644 0.006718650 4.018762e-07 1.278528e-05 2 46897009 46897109 101 - 0.279 1.034 3.444
ENSG00000180398 E002 0.0000000       2 46901870 46901873 4 -      
ENSG00000180398 E003 46.0308231 0.014658730 5.604140e-02 1.937574e-01 2 46901874 46901966 93 - 1.555 1.737 0.617
ENSG00000180398 E004 2487.8282809 0.018373985 7.309410e-01 8.547762e-01 2 46901967 46904854 2888 - 3.325 3.342 0.055
ENSG00000180398 E005 212.5957630 0.003932547 1.524146e-02 7.899018e-02 2 46904855 46904957 103 - 2.281 2.205 -0.253
ENSG00000180398 E006 371.5469802 0.010935380 1.459696e-02 7.658489e-02 2 46904958 46905244 287 - 2.528 2.424 -0.345
ENSG00000180398 E007 140.9303363 0.007485270 2.583604e-01 4.971450e-01 2 46905245 46905270 26 - 2.095 2.057 -0.126
ENSG00000180398 E008 282.9215367 0.007676300 1.797106e-01 4.035942e-01 2 46905271 46905367 97 - 2.396 2.355 -0.134
ENSG00000180398 E009 197.7938293 0.005897422 2.281485e-01 4.631144e-01 2 46905368 46905393 26 - 2.239 2.207 -0.108
ENSG00000180398 E010 253.0191628 0.002006106 6.888709e-02 2.225501e-01 2 46905394 46905465 72 - 2.348 2.310 -0.125
ENSG00000180398 E011 313.1774787 0.021186918 9.971644e-01 1.000000e+00 2 46905466 46905590 125 - 2.430 2.434 0.015
ENSG00000180398 E012 130.9512840 0.416918179 4.740921e-01 6.828874e-01 2 46905591 46905594 4 - 2.036 2.105 0.231
ENSG00000180398 E013 8.8374628 0.053549267 1.095612e-03 1.064174e-02 2 46905817 46905982 166 - 0.740 1.254 1.916
ENSG00000180398 E014 3.2134029 0.157114340 8.193250e-02 2.486314e-01 2 46907529 46907699 171 - 0.467 0.828 1.568
ENSG00000180398 E015 2.6062977 0.339191663 3.549218e-01 5.916764e-01 2 46907700 46907809 110 - 0.437 0.701 1.212
ENSG00000180398 E016 263.0872220 1.682167138 5.702618e-01 7.504519e-01 2 46907810 46907934 125 - 2.317 2.457 0.468
ENSG00000180398 E017 164.2256823 1.515368268 5.106108e-01 7.084316e-01 2 46907935 46907969 35 - 2.101 2.280 0.601
ENSG00000180398 E018 2.6734118 0.064979703 2.837248e-02 1.224162e-01 2 46908707 46909022 316 - 0.386 0.792 1.857
ENSG00000180398 E019 212.3252066 0.058962042 2.204934e-01 4.540916e-01 2 46909023 46909177 155 - 2.228 2.356 0.427
ENSG00000180398 E020 2.8508481 0.008106880 7.480636e-02 2.344245e-01 2 46910780 46910873 94 - 0.448 0.749 1.354
ENSG00000180398 E021 0.1614157 0.032978866 1.000000e+00   2 46912543 46912658 116 - 0.072 0.000 -14.917
ENSG00000180398 E022 3.2083931 0.007126867 2.006883e-04 2.683371e-03 2 46913700 46914068 369 - 0.355 0.929 2.570
ENSG00000180398 E023 1.2272097 0.141360927 2.049047e-01   2 46914069 46914118 50 - 0.237 0.513 1.637
ENSG00000180398 E024 114.7826717 0.030382644 9.253618e-02 2.684786e-01 2 46915723 46915816 94 - 1.955 2.115 0.536
ENSG00000180398 E025 3.3837545 0.007834810 1.838159e-01 4.088776e-01 2 46915981 46916112 132 - 0.524 0.750 0.978
ENSG00000180398 E026 4.5569199 0.020666261 6.363943e-04 6.894258e-03 2 46941572 46941855 284 - 0.499 1.012 2.104