ENSG00000180376

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000460838 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding processed_transcript 13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 0.6382798 0.0000000 2.2881632 0.00000000 0.5303064 7.8443374 0.03195000 0.00000000 0.08470000 0.0847000000 2.744522e-06 2.744522e-06 FALSE  
ENST00000468108 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding retained_intron 13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 2.0896741 1.3756904 4.0451890 0.57505193 0.4636956 1.5491642 0.15798750 0.18693333 0.15113333 -0.0358000000 8.852085e-01 2.744522e-06 FALSE  
ENST00000484441 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding retained_intron 13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 0.4214653 0.4292054 0.5744159 0.13684406 0.3692255 0.4120997 0.04261250 0.07666667 0.02186667 -0.0548000000 6.273929e-01 2.744522e-06    
ENST00000484623 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding processed_transcript 13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 0.1930860 0.3699721 0.4018241 0.36997214 0.2024694 0.1161345 0.01798333 0.07936667 0.01473333 -0.0646333333 9.088005e-01 2.744522e-06 FALSE  
ENST00000487739 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding retained_intron 13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 0.8698064 0.3125339 1.6317882 0.31253391 0.1066343 2.3477452 0.06756667 0.03356667 0.06100000 0.0274333333 5.465687e-01 2.744522e-06    
MSTRG.23130.16 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding   13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 1.7879950 0.7143361 3.2403130 0.06510065 1.0750478 2.1658474 0.13038750 0.11866667 0.11953333 0.0008666667 1.000000e+00 2.744522e-06 FALSE  
MSTRG.23130.17 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding   13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 0.5979506 0.4470071 0.9611939 0.15021343 0.1046589 1.0875428 0.05078750 0.06483333 0.03590000 -0.0289333333 4.556608e-01 2.744522e-06 TRUE  
MSTRG.23130.6 ENSG00000180376 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC66 protein_coding   13.84521 6.704877 26.82267 1.369711 0.4432952 1.998558 2.6106276 0.8509314 4.4886229 0.43385915 0.1992996 2.3855133 0.16256667 0.11223333 0.16720000 0.0549666667 8.118039e-01 2.744522e-06 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180376 E001 0.1614157 0.0338809760 1.000000e+00   3 56557161 56557162 2 + 0.073 0.000 -8.455
ENSG00000180376 E002 0.3393995 0.0274424043 8.036401e-01   3 56557163 56557174 12 + 0.135 0.000 -11.562
ENSG00000180376 E003 0.3393995 0.0274424043 8.036401e-01   3 56557175 56557182 8 + 0.135 0.000 -11.562
ENSG00000180376 E004 0.3393995 0.0274424043 8.036401e-01   3 56557183 56557183 1 + 0.135 0.000 -11.562
ENSG00000180376 E005 2.1436826 0.0285642788 1.628709e-02 0.082846778 3 56557184 56557187 4 + 0.528 0.000 -14.081
ENSG00000180376 E006 4.5286551 0.0059873436 6.697237e-02 0.218304258 3 56557188 56557190 3 + 0.744 0.434 -1.404
ENSG00000180376 E007 7.4462779 0.0040688024 2.171207e-01 0.449992290 3 56557191 56557202 12 + 0.908 0.747 -0.631
ENSG00000180376 E008 9.3390654 0.0033931814 3.947171e-02 0.153387909 3 56557203 56557209 7 + 1.012 0.747 -1.017
ENSG00000180376 E009 12.2726387 0.0029373313 5.907005e-02 0.200689275 3 56557210 56557210 1 + 1.108 0.896 -0.784
ENSG00000180376 E010 14.3150753 0.0027114959 2.065272e-02 0.098186140 3 56557211 56557218 8 + 1.176 0.926 -0.913
ENSG00000180376 E011 17.8857016 0.0021516435 1.503320e-02 0.078211623 3 56557219 56557227 9 + 1.266 1.030 -0.843
ENSG00000180376 E012 23.2509923 0.0026875818 1.128166e-02 0.063532490 3 56557228 56557234 7 + 1.372 1.151 -0.775
ENSG00000180376 E013 34.0255826 0.0099898475 4.129916e-03 0.029892891 3 56557235 56557253 19 + 1.535 1.284 -0.869
ENSG00000180376 E014 1.9450647 0.0103493129 5.168442e-01 0.712950315 3 56557254 56557263 10 + 0.450 0.332 -0.664
ENSG00000180376 E015 0.1723744 0.0301938100 1.452776e-01   3 56557707 56557957 251 + 0.000 0.197 12.663
ENSG00000180376 E016 0.0000000       3 56558845 56558845 1 +      
ENSG00000180376 E017 36.8768289 0.0092557044 1.224529e-03 0.011613085 3 56558846 56558854 9 + 1.573 1.297 -0.951
ENSG00000180376 E018 45.5751347 0.0049115606 2.676520e-04 0.003402461 3 56558855 56558910 56 + 1.659 1.398 -0.894
ENSG00000180376 E019 35.3478609 0.0040922919 9.099277e-03 0.054269389 3 56559569 56559594 26 + 1.541 1.346 -0.672
ENSG00000180376 E020 10.0178938 0.0036198538 5.103208e-01 0.708197572 3 56560862 56561012 151 + 0.996 0.927 -0.258
ENSG00000180376 E021 7.2150644 0.1194263912 6.522835e-01 0.804905792 3 56561013 56561222 210 + 0.863 0.800 -0.247
ENSG00000180376 E022 5.0288956 0.2227779829 9.441492e-01 0.974422179 3 56561257 56561378 122 + 0.710 0.752 0.171
ENSG00000180376 E023 4.2187350 0.0151662801 8.146493e-01 0.905021981 3 56563516 56563651 136 + 0.649 0.700 0.216
ENSG00000180376 E024 3.3819505 0.0128408643 2.892282e-02 0.124128372 3 56563652 56563683 32 + 0.477 0.828 1.519
ENSG00000180376 E025 73.8595298 0.0148407936 5.949092e-04 0.006535304 3 56563684 56563825 142 + 1.864 1.594 -0.915
ENSG00000180376 E026 49.1288730 0.0092445573 5.369028e-02 0.188326865 3 56563826 56563905 80 + 1.669 1.533 -0.463
ENSG00000180376 E027 89.4162866 0.0020870699 5.534766e-03 0.037390894 3 56563906 56564125 220 + 1.923 1.797 -0.423
ENSG00000180376 E028 0.3393995 0.0274424043 8.036401e-01   3 56564126 56564156 31 + 0.135 0.000 -11.562
ENSG00000180376 E029 2.0096061 0.0157877074 5.204303e-01 0.715236295 3 56565134 56565204 71 + 0.451 0.332 -0.670
ENSG00000180376 E030 0.6482515 0.0214893413 1.000000e+00   3 56565205 56565205 1 + 0.189 0.196 0.066
ENSG00000180376 E031 45.7325065 0.0183284047 9.973120e-02 0.281283668 3 56566594 56566660 67 + 1.639 1.504 -0.462
ENSG00000180376 E032 51.9654877 0.0235336562 2.189438e-01 0.452193180 3 56566661 56566738 78 + 1.687 1.569 -0.400
ENSG00000180376 E033 31.6858999 0.0274351864 5.299309e-01 0.722042052 3 56566739 56566740 2 + 1.468 1.411 -0.196
ENSG00000180376 E034 26.2939968 0.0109404473 4.726979e-01 0.681973228 3 56566741 56566759 19 + 1.389 1.332 -0.197
ENSG00000180376 E035 1.9630379 0.0100635139 5.015166e-01 0.701894556 3 56566783 56566949 167 + 0.390 0.517 0.657
ENSG00000180376 E036 37.9603182 0.0224479240 3.253764e-01 0.564612764 3 56566950 56566950 1 + 1.550 1.457 -0.319
ENSG00000180376 E037 72.4051293 0.0102935110 1.155323e-01 0.308368176 3 56566951 56567053 103 + 1.826 1.721 -0.356
ENSG00000180376 E038 25.6084765 0.0013658876 2.265020e-01 0.461201702 3 56569313 56569637 325 + 1.385 1.299 -0.301
ENSG00000180376 E039 20.6071684 0.0019121909 9.328070e-01 0.968519074 3 56569638 56570746 1109 + 1.270 1.273 0.011
ENSG00000180376 E040 2.9375174 0.0104025481 8.207222e-01 0.908476210 3 56571167 56571180 14 + 0.550 0.517 -0.154
ENSG00000180376 E041 56.7543896 0.0006233927 3.111122e-01 0.551520440 3 56571181 56571302 122 + 1.709 1.665 -0.149
ENSG00000180376 E042 1.3086294 0.0130143722 4.222318e-01   3 56571303 56571379 77 + 0.281 0.434 0.919
ENSG00000180376 E043 11.0727249 0.0033625878 9.390852e-01 0.971853615 3 56572337 56572428 92 + 1.012 1.031 0.072
ENSG00000180376 E044 1.8670710 0.0214731147 8.069782e-03 0.049640834 3 56572429 56572910 482 + 0.237 0.701 2.469
ENSG00000180376 E045 51.9622060 0.0010983658 8.491976e-01 0.924492263 3 56592970 56593101 132 + 1.658 1.681 0.076
ENSG00000180376 E046 54.1750141 0.0009167395 8.402235e-01 0.919567363 3 56593491 56593619 129 + 1.674 1.696 0.074
ENSG00000180376 E047 56.0818752 0.0050431727 4.218908e-01 0.645088541 3 56593620 56593711 92 + 1.677 1.734 0.195
ENSG00000180376 E048 44.3959721 0.0014923625 9.438368e-01 0.974277365 3 56593712 56593741 30 + 1.589 1.595 0.021
ENSG00000180376 E049 65.5406896 0.0018176609 8.178969e-01 0.906912810 3 56593944 56594028 85 + 1.758 1.757 -0.004
ENSG00000180376 E050 4.9661463 0.0061318219 4.973884e-01 0.699135996 3 56598204 56598300 97 + 0.744 0.647 -0.403
ENSG00000180376 E051 45.9873166 0.0021094912 5.431942e-01 0.731351827 3 56613589 56613610 22 + 1.611 1.582 -0.099
ENSG00000180376 E052 90.7754050 0.0005895682 1.605786e-01 0.377642474 3 56613611 56613750 140 + 1.878 1.948 0.233
ENSG00000180376 E053 75.3752655 0.0005156076 6.031704e-01 0.772327215 3 56615128 56615272 145 + 1.812 1.847 0.119
ENSG00000180376 E054 15.4578791 0.0875734901 7.766496e-01 0.882693606 3 56615273 56615417 145 + 1.128 1.231 0.367
ENSG00000180376 E055 5.3803767 0.0276397910 9.947102e-01 0.998940389 3 56615869 56615903 35 + 0.745 0.747 0.008
ENSG00000180376 E056 9.7324057 0.0034956893 7.162764e-01 0.845780854 3 56615904 56615921 18 + 0.988 0.955 -0.123
ENSG00000180376 E057 64.1928179 0.0007797801 9.495337e-01 0.976797504 3 56615922 56616053 132 + 1.750 1.765 0.051
ENSG00000180376 E058 27.2752200 0.0665455969 2.690736e-01 0.508857252 3 56616054 56617100 1047 + 1.315 1.559 0.839
ENSG00000180376 E059 1.9390954 0.0101156213 1.516588e-01 0.364739963 3 56617101 56617111 11 + 0.477 0.197 -1.803
ENSG00000180376 E060 132.8335231 0.0019028432 1.552476e-01 0.369811774 3 56617112 56617400 289 + 2.047 2.112 0.219
ENSG00000180376 E061 87.1036155 0.0019417457 6.276718e-02 0.208969224 3 56617401 56617529 129 + 1.854 1.948 0.315
ENSG00000180376 E062 69.3344927 0.0121578111 6.575540e-02 0.215636498 3 56617530 56617605 76 + 1.746 1.873 0.428
ENSG00000180376 E063 36.7510159 0.0500391424 8.719399e-02 0.258600188 3 56617606 56618171 566 + 1.441 1.676 0.802
ENSG00000180376 E064 61.2050056 0.0077502480 3.099586e-02 0.130321356 3 56618172 56618212 41 + 1.686 1.830 0.485
ENSG00000180376 E065 28.7849341 0.0544502769 4.710042e-02 0.172773103 3 56618213 56619270 1058 + 1.307 1.624 1.091
ENSG00000180376 E066 139.3426816 0.0004293189 4.501689e-05 0.000760914 3 56619271 56619527 257 + 2.042 2.186 0.482
ENSG00000180376 E067 84.6628252 0.0145426746 3.599282e-03 0.026927914 3 56619777 56619901 125 + 1.808 2.019 0.710
ENSG00000180376 E068 40.9819309 0.0424934540 3.602076e-03 0.026941875 3 56621532 56625857 4326 + 1.456 1.783 1.112
ENSG00000180376 E069 0.3088520 0.0266588216 4.079114e-01   3 56626516 56626610 95 + 0.073 0.196 1.652