ENSG00000180182

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324817 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding protein_coding 20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 2.3507080 2.418704 2.3868029 0.6345705 0.09330328 -0.01907544 0.11970833 0.11346667 0.09746667 -0.01600000 0.8458769645 0.0002020714 FALSE TRUE
ENST00000433003 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding protein_coding 20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 2.1943066 3.424041 1.4367939 0.3739775 0.07948371 -1.24704768 0.12372917 0.17360000 0.05870000 -0.11490000 0.0002020714 0.0002020714 FALSE TRUE
MSTRG.34112.4 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding   20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 3.5901584 1.233617 5.3372327 0.7585374 0.66048749 2.10425007 0.14074167 0.06486667 0.21616667 0.15130000 0.5722932657 0.0002020714 FALSE TRUE
MSTRG.34112.5 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding   20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 6.3199914 7.265977 5.5223730 1.9678764 0.63470147 -0.39524265 0.30334167 0.34113333 0.22426667 -0.11686667 0.3864722493 0.0002020714 FALSE TRUE
MSTRG.34112.6 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding   20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 1.1739470 0.000000 0.8054943 0.0000000 0.80549434 6.34960295 0.06023333 0.00000000 0.03156667 0.03156667 0.9015524461 0.0002020714 FALSE TRUE
MSTRG.34112.7 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding   20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 0.9738695 1.158550 2.9208084 0.8331097 0.90794747 1.32657865 0.05003333 0.05493333 0.12056667 0.06563333 0.7779679443 0.0002020714 FALSE TRUE
MSTRG.34112.8 ENSG00000180182 HEK293_OSMI2_6hA HEK293_TMG_6hB MED14 protein_coding   20.96005 20.63304 24.57642 3.960957 0.6784232 0.2522068 2.3843618 3.458551 5.0730318 0.5647264 0.12222184 0.55135622 0.09944167 0.17026667 0.20680000 0.03653333 0.6046066845 0.0002020714 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180182 E001 2.1118296 0.1423724916 3.575867e-01 5.937715e-01 X 40648305 40649542 1238 - 0.578 0.373 -1.037
ENSG00000180182 E002 5.3197146 0.5572680994 8.192163e-01 9.076257e-01 X 40649543 40649605 63 - 0.708 0.871 0.648
ENSG00000180182 E003 21.1883673 0.0638638521 8.407342e-02 2.529178e-01 X 40649606 40649672 67 - 1.194 1.453 0.903
ENSG00000180182 E004 79.3639914 0.0147645737 2.195178e-02 1.024153e-01 X 40649673 40650021 349 - 1.806 1.983 0.594
ENSG00000180182 E005 134.1693070 0.0031552764 1.335094e-04 1.903969e-03 X 40650022 40650420 399 - 2.042 2.207 0.552
ENSG00000180182 E006 306.3303186 0.0008412639 1.071755e-02 6.118143e-02 X 40650421 40651475 1055 - 2.452 2.520 0.227
ENSG00000180182 E007 243.7866299 0.0011300777 2.520694e-06 6.388178e-05 X 40651476 40651879 404 - 2.316 2.452 0.456
ENSG00000180182 E008 26.7974081 0.0261617226 5.330428e-03 3.634256e-02 X 40653872 40654363 492 - 1.284 1.561 0.959
ENSG00000180182 E009 230.8237039 0.0006144359 9.153441e-09 4.339656e-07 X 40654364 40654556 193 - 2.282 2.436 0.515
ENSG00000180182 E010 182.0135962 0.0002887855 7.718516e-07 2.268573e-05 X 40654935 40655060 126 - 2.189 2.328 0.465
ENSG00000180182 E011 168.6953694 0.0010257345 1.764865e-04 2.408313e-03 X 40659227 40659334 108 - 2.167 2.287 0.403
ENSG00000180182 E012 245.7178371 0.0026735447 1.567707e-03 1.409534e-02 X 40659428 40659607 180 - 2.337 2.447 0.365
ENSG00000180182 E013 1.4512641 0.0125599628 3.586501e-01 5.946923e-01 X 40659608 40659819 212 - 0.458 0.301 -0.907
ENSG00000180182 E014 273.0775374 0.0018934716 5.262373e-03 3.599877e-02 X 40662925 40663160 236 - 2.396 2.485 0.297
ENSG00000180182 E015 191.0808412 0.0007096197 4.429523e-02 1.658348e-01 X 40664307 40664489 183 - 2.255 2.319 0.212
ENSG00000180182 E016 109.6705518 0.0004792583 7.021588e-03 4.474398e-02 X 40666720 40666851 132 - 1.996 2.097 0.339
ENSG00000180182 E017 124.6060884 0.0005347245 1.060454e-01 2.924194e-01 X 40671861 40671972 112 - 2.070 2.131 0.202
ENSG00000180182 E018 131.1277373 0.0006758198 4.557353e-01 6.700518e-01 X 40675221 40675361 141 - 2.105 2.136 0.105
ENSG00000180182 E019 253.3040845 0.0002257425 6.261307e-01 7.880311e-01 X 40679864 40680133 270 - 2.409 2.405 -0.012
ENSG00000180182 E020 203.9478542 0.0003065415 1.266736e-02 6.911513e-02 X 40680758 40680910 153 - 2.340 2.285 -0.185
ENSG00000180182 E021 0.3032425 0.0274424043 1.859760e-01   X 40681848 40681851 4 - 0.000 0.222 11.294
ENSG00000180182 E022 157.4911300 0.0046106103 1.711078e-01 3.919875e-01 X 40681852 40681943 92 - 2.226 2.174 -0.171
ENSG00000180182 E023 178.7858010 0.0030673124 8.281719e-02 2.503563e-01 X 40682603 40682749 147 - 2.285 2.227 -0.194
ENSG00000180182 E024 172.8177870 0.0004295878 2.310868e-01 4.664553e-01 X 40682836 40682996 161 - 2.255 2.229 -0.089
ENSG00000180182 E025 95.6421013 0.0004463721 3.173337e-01 5.573084e-01 X 40688454 40688530 77 - 1.965 2.008 0.145
ENSG00000180182 E026 149.2974058 0.0003905042 7.345055e-01 8.569875e-01 X 40692183 40692317 135 - 2.182 2.178 -0.011
ENSG00000180182 E027 171.6532380 0.0029428288 8.328140e-01 9.153812e-01 X 40692708 40692902 195 - 2.235 2.245 0.033
ENSG00000180182 E028 141.3099989 0.0025299785 6.860835e-02 2.219409e-01 X 40697024 40697183 160 - 2.187 2.124 -0.209
ENSG00000180182 E029 115.8218418 0.0003755362 8.190499e-05 1.266559e-03 X 40701165 40701243 79 - 2.127 2.004 -0.414
ENSG00000180182 E030 150.0838939 0.0004347571 2.851989e-05 5.165121e-04 X 40703444 40703569 126 - 2.237 2.120 -0.392
ENSG00000180182 E031 157.9418398 0.0002599514 8.673587e-06 1.855132e-04 X 40709348 40709459 112 - 2.258 2.138 -0.399
ENSG00000180182 E032 150.0532060 0.0003050634 3.175368e-06 7.800528e-05 X 40709979 40710129 151 - 2.238 2.109 -0.433
ENSG00000180182 E033 131.5996022 0.0011860347 1.383082e-04 1.960922e-03 X 40711169 40711301 133 - 2.180 2.053 -0.427
ENSG00000180182 E034 135.0941074 0.0019461063 6.084661e-04 6.653244e-03 X 40712186 40712293 108 - 2.187 2.065 -0.409
ENSG00000180182 E035 161.1096808 0.0034003445 8.801939e-04 8.931712e-03 X 40712914 40713042 129 - 2.265 2.137 -0.430
ENSG00000180182 E036 120.7245082 0.0003862206 3.056321e-04 3.786455e-03 X 40713778 40713831 54 - 2.136 2.024 -0.375
ENSG00000180182 E037 108.2314147 0.0008858954 3.948825e-05 6.805371e-04 X 40713832 40713877 46 - 2.101 1.958 -0.477
ENSG00000180182 E038 101.4402391 0.0003781072 4.248887e-06 1.000119e-04 X 40713878 40713907 30 - 2.081 1.924 -0.526
ENSG00000180182 E039 150.0666403 0.0003033153 5.396134e-05 8.890925e-04 X 40714537 40714710 174 - 2.232 2.121 -0.371
ENSG00000180182 E040 3.2894097 0.3341272715 2.784565e-02 1.208555e-01 X 40714711 40715051 341 - 0.211 0.842 3.249
ENSG00000180182 E041 4.2387180 0.0066782265 6.089547e-01 7.762045e-01 X 40715118 40715220 103 - 0.677 0.753 0.316
ENSG00000180182 E042 0.1426347 0.0324277398 5.243126e-01   X 40726455 40726527 73 - 0.118 0.000 -10.144
ENSG00000180182 E043 0.3040503 0.0274424043 2.213483e-01   X 40726528 40726745 218 - 0.211 0.000 -11.145
ENSG00000180182 E044 86.6884383 0.0004992787 2.448772e-05 4.540428e-04 X 40726746 40726851 106 - 2.015 1.859 -0.524
ENSG00000180182 E045 45.0874806 0.0016994203 3.583031e-02 1.437857e-01 X 40729319 40729345 27 - 1.718 1.612 -0.360
ENSG00000180182 E046 0.1779838 0.0362685874 5.237170e-01   X 40729346 40729540 195 - 0.118 0.000 -10.148
ENSG00000180182 E047 45.2356798 0.0057588230 5.702397e-01 7.504519e-01 X 40735198 40735542 345 - 1.649 1.693 0.149
ENSG00000180182 E048 21.4455450 0.2988356177 2.461740e-01 4.838211e-01 X 40735722 40735857 136 - 1.226 1.456 0.799
ENSG00000180182 E049 7.7500191 0.0049136465 6.818146e-01 8.238347e-01 X 40735858 40735960 103 - 0.929 0.984 0.205