ENSG00000180011

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322342 ENSG00000180011 HEK293_OSMI2_6hA HEK293_TMG_6hB ZADH2 protein_coding protein_coding 13.70927 13.05239 14.75516 2.407546 0.976022 0.1767789 0.817254 1.0547357 0.4206229 0.1125098 0.21805046 -1.3059984 0.06290833 0.08420000 0.02703333 -0.05716667 0.4922604867 0.0003662925 FALSE TRUE
ENST00000537114 ENSG00000180011 HEK293_OSMI2_6hA HEK293_TMG_6hB ZADH2 protein_coding protein_coding 13.70927 13.05239 14.75516 2.407546 0.976022 0.1767789 3.621541 2.3767413 5.1867207 0.3846223 0.33905132 1.1225593 0.26279583 0.18356667 0.35223333 0.16866667 0.0003662925 0.0003662925 FALSE TRUE
ENST00000582437 ENSG00000180011 HEK293_OSMI2_6hA HEK293_TMG_6hB ZADH2 protein_coding protein_coding 13.70927 13.05239 14.75516 2.407546 0.976022 0.1767789 4.488130 4.7692796 3.9919721 1.2127905 0.24391847 -0.2560821 0.32787083 0.35723333 0.27363333 -0.08360000 0.5290449879 0.0003662925 FALSE FALSE
MSTRG.15916.4 ENSG00000180011 HEK293_OSMI2_6hA HEK293_TMG_6hB ZADH2 protein_coding   13.70927 13.05239 14.75516 2.407546 0.976022 0.1767789 1.432923 0.9533639 2.5110239 0.2012764 0.08984229 1.3878571 0.10309583 0.07316667 0.17233333 0.09916667 0.0240098510 0.0003662925 TRUE TRUE
MSTRG.15916.6 ENSG00000180011 HEK293_OSMI2_6hA HEK293_TMG_6hB ZADH2 protein_coding   13.70927 13.05239 14.75516 2.407546 0.976022 0.1767789 2.550592 3.0870793 2.0177497 0.6490106 0.74149330 -0.6110287 0.18504167 0.23663333 0.13113333 -0.10550000 0.4962035472 0.0003662925 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000180011 E001 2.6798634 0.0101046613 9.027985e-02 0.2642827526 18 75137601 75137785 185 - 0.383 0.683 1.433
ENSG00000180011 E002 9.7687733 0.0195042973 1.621681e-03 0.0144747490 18 75195113 75195454 342 - 0.773 1.183 1.530
ENSG00000180011 E003 11.3720987 0.0050435716 5.904140e-06 0.0001331022 18 75195455 75195682 228 - 0.748 1.250 1.868
ENSG00000180011 E004 5.7291508 0.0631575807 2.388633e-02 0.1087257503 18 75195683 75195744 62 - 0.541 0.959 1.713
ENSG00000180011 E005 19.3557752 0.0022028983 7.146452e-06 0.0001566583 18 75195745 75196738 994 - 1.065 1.435 1.304
ENSG00000180011 E006 124.8447415 0.0007759460 8.796302e-01 0.9410920938 18 75196739 75199456 2718 - 2.110 2.107 -0.011
ENSG00000180011 E007 76.3787812 0.0094431183 3.449776e-02 0.1402007183 18 75199457 75200165 709 - 1.961 1.832 -0.433
ENSG00000180011 E008 26.2774426 0.0063010591 1.531243e-02 0.0792443110 18 75200166 75200209 44 - 1.544 1.355 -0.652
ENSG00000180011 E009 261.4041369 0.0009033175 1.139926e-06 0.0000318188 18 75200210 75201716 1507 - 2.482 2.371 -0.368
ENSG00000180011 E010 100.9244227 0.0006853259 2.634589e-01 0.5026952840 18 75201717 75201877 161 - 1.996 2.026 0.100
ENSG00000180011 E011 105.2208302 0.0030353979 3.082042e-01 0.5488271676 18 75201878 75202087 210 - 2.005 2.043 0.128
ENSG00000180011 E012 96.0620733 0.0020120723 4.861191e-02 0.1763978677 18 75202088 75202340 253 - 1.949 2.019 0.238
ENSG00000180011 E013 5.3349869 1.4936496189 6.036314e-01 0.7725974313 18 75205193 75205513 321 - 0.773 0.821 0.189
ENSG00000180011 E014 0.7389688 0.4215780658 1.589280e-01   18 75208361 75208419 59 - 0.379 0.109 -2.281
ENSG00000180011 E015 1.1503543 0.9589981205 4.356718e-01   18 75208420 75208466 47 - 0.381 0.311 -0.422
ENSG00000180011 E016 53.0528098 0.0009808325 7.208931e-03 0.0456177037 18 75208850 75209181 332 - 1.661 1.784 0.415