ENSG00000179387

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323570 ENSG00000179387 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMOD2 protein_coding protein_coding 19.8837 2.507442 34.44284 0.1418797 1.271975 3.774592 11.18605574 1.5809564 19.3953098 0.1482984 0.4955667 3.608485 0.60781250 0.6318000 0.56546667 -0.06633333 8.239581e-01 2.420748e-12 FALSE TRUE
MSTRG.25515.2 ENSG00000179387 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMOD2 protein_coding   19.8837 2.507442 34.44284 0.1418797 1.271975 3.774592 0.62243529 0.2634320 0.7942854 0.2634320 0.2197584 1.556526 0.05413333 0.1136667 0.02353333 -0.09013333 9.536603e-01 2.420748e-12 FALSE TRUE
MSTRG.25515.3 ENSG00000179387 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMOD2 protein_coding   19.8837 2.507442 34.44284 0.1418797 1.271975 3.774592 6.29902396 0.0000000 11.5596899 0.0000000 1.5231800 10.176134 0.22672500 0.0000000 0.33340000 0.33340000 2.420748e-12 2.420748e-12 FALSE TRUE
MSTRG.25515.6 ENSG00000179387 HEK293_OSMI2_6hA HEK293_TMG_6hB ELMOD2 protein_coding   19.8837 2.507442 34.44284 0.1418797 1.271975 3.774592 0.03915564 0.3132451 0.0000000 0.3132451 0.0000000 -5.014557 0.01405833 0.1124667 0.00000000 -0.11246667 5.373528e-01 2.420748e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000179387 E001 0.7860845 0.0172107474 1.00000000   4 140524154 140524167 14 + 0.177 0.000 -15.302
ENSG00000179387 E002 1.7148037 0.0118288087 0.33685800 0.57523768 4 140524168 140524175 8 + 0.323 0.000 -17.146
ENSG00000179387 E003 13.7155552 0.0028334142 0.78324034 0.88654130 4 140524176 140524181 6 + 0.951 0.916 -0.133
ENSG00000179387 E004 34.7508968 0.0021798685 0.74501672 0.86367746 4 140524182 140524217 36 + 1.318 1.357 0.134
ENSG00000179387 E005 58.9142734 0.0007601560 0.60660301 0.77462566 4 140524218 140524275 58 + 1.538 1.583 0.154
ENSG00000179387 E006 37.1293642 0.0010619140 0.79041388 0.89077807 4 140524276 140524280 5 + 1.345 1.376 0.109
ENSG00000179387 E007 1.2140381 0.0218982742 0.03154685   4 140524281 140524435 155 + 0.177 0.612 2.620
ENSG00000179387 E008 2.1475590 0.0284668376 0.04506736 0.16778414 4 140524436 140524519 84 + 0.302 0.708 2.029
ENSG00000179387 E009 2.8005624 0.0102413447 0.31023324 0.55071478 4 140524520 140524617 98 + 0.399 0.613 1.039
ENSG00000179387 E010 0.7555370 0.0174186930 0.42542068   4 140524618 140524661 44 + 0.147 0.308 1.364
ENSG00000179387 E011 2.6757811 0.0149690465 0.64061780 0.79732164 4 140524662 140525419 758 + 0.382 0.488 0.557
ENSG00000179387 E012 122.9036555 0.0012636317 0.49086343 0.69456165 4 140525420 140525570 151 + 1.852 1.895 0.144
ENSG00000179387 E013 0.1614157 0.0326476231 0.57255017   4 140526642 140526797 156 + 0.042 0.000 -13.868
ENSG00000179387 E014 81.8503797 0.0006904505 0.38631070 0.61755820 4 140527466 140527494 29 + 1.678 1.739 0.207
ENSG00000179387 E015 4.9791668 0.0082629346 0.51084230 0.70860966 4 140527495 140527952 458 + 0.581 0.711 0.559
ENSG00000179387 E016 1.3144265 0.0133523876 0.73629247   4 140535417 140535732 316 + 0.231 0.309 0.557
ENSG00000179387 E017 125.6588983 0.0017503806 0.55657328 0.74088200 4 140535733 140535830 98 + 1.868 1.841 -0.091
ENSG00000179387 E018 132.9031658 0.0004475315 0.22459572 0.45890691 4 140537412 140537541 130 + 1.893 1.834 -0.196
ENSG00000179387 E019 145.2778899 0.0003802260 0.09923392 0.28043536 4 140540168 140540301 134 + 1.932 1.854 -0.264
ENSG00000179387 E020 1.4157272 0.1581250409 0.01247325 0.06833566 4 140542425 140542573 149 + 0.175 0.712 3.065
ENSG00000179387 E021 94.2446867 0.0004322224 0.24363029 0.48066297 4 140542574 140542642 69 + 1.746 1.678 -0.231
ENSG00000179387 E022 102.9813683 0.0004558508 0.32521589 0.56444385 4 140543453 140543586 134 + 1.784 1.731 -0.179
ENSG00000179387 E023 3.5759780 0.0070965815 0.18270024 0.40754362 4 140543717 140543955 239 + 0.449 0.711 1.194
ENSG00000179387 E024 1.1089159 0.0263435927 0.65281007   4 140549871 140549957 87 + 0.231 0.000 -16.602
ENSG00000179387 E025 865.1270435 0.0056151022 0.53129662 0.72297899 4 140550230 140553770 3541 + 2.695 2.713 0.061
ENSG00000179387 E026 1.4888261 0.0129617326 0.04377150 0.16452507 4 140557971 140558115 145 + 0.205 0.614 2.364