ENSG00000179348

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000430265 ENSG00000179348 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA2 protein_coding protein_coding 30.87672 38.98753 18.03824 4.088395 0.3249562 -1.111525 4.696403 6.524685 2.454969 1.3641123 0.54734106 -1.4065483 0.15287083 0.16320000 0.13520000 -0.02800000 8.658700e-01 7.422766e-05 FALSE TRUE
ENST00000489987 ENSG00000179348 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA2 protein_coding retained_intron 30.87672 38.98753 18.03824 4.088395 0.3249562 -1.111525 2.349661 1.699102 2.431851 0.3835776 0.28115747 0.5147365 0.08627917 0.04516667 0.13450000 0.08933333 4.767029e-02 7.422766e-05   FALSE
ENST00000696672 ENSG00000179348 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA2 protein_coding protein_coding 30.87672 38.98753 18.03824 4.088395 0.3249562 -1.111525 14.096690 17.861220 6.822513 2.1643145 0.47572397 -1.3871499 0.43982500 0.45666667 0.37786667 -0.07880000 4.421183e-01 7.422766e-05 FALSE FALSE
MSTRG.23640.10 ENSG00000179348 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA2 protein_coding   30.87672 38.98753 18.03824 4.088395 0.3249562 -1.111525 1.691748 1.406767 2.806853 0.1781955 0.08140292 0.9914820 0.06814167 0.03790000 0.15556667 0.11766667 7.422766e-05 7.422766e-05 FALSE TRUE
MSTRG.23640.9 ENSG00000179348 HEK293_OSMI2_6hA HEK293_TMG_6hB GATA2 protein_coding   30.87672 38.98753 18.03824 4.088395 0.3249562 -1.111525 6.657435 9.598845 1.792341 0.6919349 0.26585426 -2.4144912 0.20385000 0.24820000 0.09996667 -0.14823333 9.812553e-04 7.422766e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000179348 E001 197.4510097 0.4741502758 0.284507440 0.52502742 3 128479427 128480028 602 - 2.133 2.210 0.258
ENSG00000179348 E002 102.2864549 0.2935710648 0.299016215 0.53945309 3 128480029 128480113 85 - 1.887 1.919 0.109
ENSG00000179348 E003 66.3940802 0.1747837864 0.357102744 0.59336663 3 128480114 128480145 32 - 1.720 1.731 0.037
ENSG00000179348 E004 412.0458381 1.1087982509 0.539306536 0.72849866 3 128480146 128480768 623 - 2.531 2.510 -0.072
ENSG00000179348 E005 203.9743009 0.7522273800 0.439587509 0.65836417 3 128480769 128481016 248 - 2.200 2.212 0.041
ENSG00000179348 E006 63.3253751 0.1442902769 0.404974513 0.63223636 3 128481017 128481018 2 - 1.708 1.709 0.003
ENSG00000179348 E007 234.7364092 0.7948101236 0.415474062 0.64018172 3 128481019 128481310 292 - 2.239 2.278 0.130
ENSG00000179348 E008 84.1083896 0.2288784604 0.429048526 0.65033964 3 128481311 128481318 8 - 1.838 1.827 -0.036
ENSG00000179348 E009 135.6739656 0.3868985969 0.387918537 0.61886434 3 128481819 128481902 84 - 2.031 2.035 0.014
ENSG00000179348 E010 98.7956505 0.2556894851 0.344224438 0.58182026 3 128481903 128481944 42 - 1.877 1.903 0.089
ENSG00000179348 E011 12.0400376 0.1716063901 0.353637678 0.59054832 3 128481945 128482078 134 - 1.247 0.950 -1.075
ENSG00000179348 E012 160.3748379 0.4363497782 0.360853511 0.59631810 3 128483860 128484005 146 - 2.088 2.111 0.076
ENSG00000179348 E013 228.7505651 0.7890911598 0.463175630 0.67526878 3 128485727 128486147 421 - 2.260 2.259 -0.003
ENSG00000179348 E014 127.4476551 0.2915821818 0.211900730 0.44396854 3 128486148 128486368 221 - 1.916 2.027 0.374
ENSG00000179348 E015 107.8618308 0.0004605705 0.010481040 0.06018332 3 128486803 128487007 205 - 1.880 1.954 0.249
ENSG00000179348 E016 63.9229122 0.0562498964 0.331609367 0.57047070 3 128487008 128487076 69 - 1.587 1.738 0.512
ENSG00000179348 E017 79.3496994 0.0965410897 0.901946164 0.95289473 3 128487711 128487921 211 - 1.756 1.815 0.200
ENSG00000179348 E018 7.0173565 0.0045255920 0.388462461 0.61922027 3 128488352 128488795 444 - 0.945 0.797 -0.566
ENSG00000179348 E019 2.9962431 0.0323561816 0.006809784 0.04373399 3 128488796 128489034 239 - 0.874 0.387 -2.171
ENSG00000179348 E020 2.8509974 0.0327199166 0.292589815 0.53328697 3 128489187 128489567 381 - 0.362 0.550 0.969
ENSG00000179348 E021 1.3985389 0.0131981782 0.126742368 0.32661754 3 128489650 128489783 134 - 0.556 0.255 -1.700
ENSG00000179348 E022 1.9047033 0.0144663119 0.122017687 0.31905598 3 128489784 128489861 78 - 0.628 0.326 -1.536
ENSG00000179348 E023 3.6426417 0.0080315263 0.005952921 0.03950693 3 128489862 128490299 438 - 0.911 0.465 -1.896
ENSG00000179348 E024 1.7798384 2.5564142459 0.320462913 0.56009937 3 128490300 128491352 1053 - 0.913 0.000 -16.323
ENSG00000179348 E025 0.1779838 0.4731818457 0.135834034   3 128491785 128491907 123 - 0.220 0.000 -12.887
ENSG00000179348 E026 0.0000000       3 128491908 128492003 96 -      
ENSG00000179348 E027 0.0000000       3 128492004 128492222 219 -      
ENSG00000179348 E028 0.3559677 1.3960972945 0.195407967   3 128492223 128492898 676 - 0.376 0.000 -13.941
ENSG00000179348 E029 36.5058281 3.3707274748 0.426301752 0.64825787 3 128492899 128501558 8660 - 2.172 0.132 -8.701
ENSG00000179348 E030 12.3951850 2.0558328610 0.199933188 0.42959226 3 128501559 128510534 8976 - 1.707 0.060 -8.408