ENSG00000179295

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351677 ENSG00000179295 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN11 protein_coding protein_coding 41.74963 20.48226 66.46519 4.714384 2.968534 1.697737 27.484664 13.0603460 52.3331148 3.3614859 2.6702655 2.0017024 0.56292083 0.63370000 0.787000000 0.15330000 0.2417448955 0.0003731116 FALSE TRUE
ENST00000635625 ENSG00000179295 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN11 protein_coding protein_coding 41.74963 20.48226 66.46519 4.714384 2.968534 1.697737 4.643434 0.6697584 8.5461035 0.2741565 0.8844546 3.6538600 0.07612083 0.03060000 0.128100000 0.09750000 0.0003731116 0.0003731116 FALSE TRUE
ENST00000688597 ENSG00000179295 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN11 protein_coding protein_coding 41.74963 20.48226 66.46519 4.714384 2.968534 1.697737 3.101925 3.1749204 0.6012024 1.5045681 0.6012024 -2.3815351 0.13355000 0.13456667 0.008566667 -0.12600000 0.0987910565 0.0003731116 FALSE TRUE
ENST00000690472 ENSG00000179295 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN11 protein_coding processed_transcript 41.74963 20.48226 66.46519 4.714384 2.968534 1.697737 1.959613 1.5702994 0.0000000 1.5702994 0.0000000 -7.3040541 0.11241250 0.06083333 0.000000000 -0.06083333 0.7833082269 0.0003731116 FALSE TRUE
ENST00000692624 ENSG00000179295 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN11 protein_coding nonsense_mediated_decay 41.74963 20.48226 66.46519 4.714384 2.968534 1.697737 1.835464 0.7269110 0.5592271 0.7269110 0.5592271 -0.3724861 0.03500833 0.06560000 0.009233333 -0.05636667 0.9610133741 0.0003731116 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000179295 E001 0.1779838 0.0375157963 1.000000e+00   12 112417901 112418350 450 + 0.069 0.000 -23.333
ENSG00000179295 E002 0.0000000       12 112418351 112418404 54 +      
ENSG00000179295 E003 0.1779838 0.0375157963 1.000000e+00   12 112418405 112418562 158 + 0.069 0.000 -23.317
ENSG00000179295 E004 0.3032425 0.0274424043 3.820282e-02   12 112418563 112418906 344 + 0.000 0.344 27.904
ENSG00000179295 E005 0.1723744 0.0669555373 1.621421e-01   12 112418907 112418908 2 + 0.000 0.206 26.908
ENSG00000179295 E006 0.4341107 0.0227721720 9.010147e-03   12 112418909 112418910 2 + 0.000 0.449 28.487
ENSG00000179295 E007 8.8355990 0.0868010711 6.322957e-02 2.099710e-01 12 112418911 112418946 36 + 0.806 1.174 1.370
ENSG00000179295 E008 125.1326528 0.0054255514 8.472530e-01 9.234578e-01 12 112418947 112419111 165 + 2.005 2.092 0.289
ENSG00000179295 E009 88.0617884 0.0005915508 1.750542e-01 3.972257e-01 12 112419112 112419125 14 + 1.868 1.901 0.109
ENSG00000179295 E010 218.4575905 0.0002185856 4.840380e-04 5.530565e-03 12 112446276 112446398 123 + 2.268 2.261 -0.022
ENSG00000179295 E011 337.5654293 0.0005137053 2.253252e-06 5.795153e-05 12 112450318 112450512 195 + 2.460 2.436 -0.079
ENSG00000179295 E012 284.0325050 0.0015442304 8.846278e-04 8.969499e-03 12 112453195 112453328 134 + 2.382 2.372 -0.032
ENSG00000179295 E013 228.1206499 0.0007481400 1.764960e-07 6.170216e-06 12 112453329 112453387 59 + 2.301 2.232 -0.230
ENSG00000179295 E014 307.7369867 0.0026749584 5.066857e-05 8.414520e-04 12 112454564 112454680 117 + 2.425 2.376 -0.164
ENSG00000179295 E015 279.9676999 0.0014657444 7.900416e-05 1.228075e-03 12 112455950 112456063 114 + 2.381 2.352 -0.098
ENSG00000179295 E016 1.1481414 0.0777886966 2.210614e-01   12 112457291 112457486 196 + 0.227 0.528 1.787
ENSG00000179295 E017 246.7648453 0.0013908024 6.049947e-04 6.622108e-03 12 112472944 112473040 97 + 2.322 2.305 -0.057
ENSG00000179295 E018 248.5826317 0.0005645017 1.951580e-07 6.744467e-06 12 112477651 112477730 80 + 2.335 2.276 -0.195
ENSG00000179295 E019 265.9239674 0.0001872597 8.570970e-06 1.835727e-04 12 112477857 112477931 75 + 2.356 2.334 -0.076
ENSG00000179295 E020 293.9348350 0.0001878257 1.143395e-08 5.290864e-07 12 112477932 112478015 84 + 2.405 2.355 -0.167
ENSG00000179295 E021 0.0000000       12 112481546 112481846 301 +      
ENSG00000179295 E022 291.4935526 0.0002101079 8.758462e-08 3.292139e-06 12 112482074 112482205 132 + 2.400 2.358 -0.140
ENSG00000179295 E023 0.3559677 0.5394088603 9.141766e-01   12 112486454 112486462 9 + 0.132 0.000 -24.359
ENSG00000179295 E024 31.7466348 0.0014128488 1.549085e-01 3.692889e-01 12 112486463 112486474 12 + 1.445 1.431 -0.048
ENSG00000179295 E025 249.8431850 0.0002124296 8.528505e-05 1.309645e-03 12 112486475 112486629 155 + 2.326 2.314 -0.042
ENSG00000179295 E026 2.5812894 0.0307518174 1.414712e-01 3.497066e-01 12 112486630 112486923 294 + 0.406 0.719 1.453
ENSG00000179295 E027 3.9489929 0.0616491921 8.775138e-01 9.399767e-01 12 112487820 112488398 579 + 0.631 0.663 0.138
ENSG00000179295 E028 2.4438883 0.2078453605 5.156876e-01 7.120528e-01 12 112488399 112488442 44 + 0.435 0.609 0.831
ENSG00000179295 E029 139.2087509 0.0003934601 1.595000e-05 3.146333e-04 12 112488443 112488510 68 + 2.085 2.018 -0.222
ENSG00000179295 E030 209.8325926 0.0002891119 4.137361e-02 1.582877e-01 12 112489024 112489175 152 + 2.241 2.274 0.110
ENSG00000179295 E031 1.6729670 0.0137464953 7.727878e-01 8.803546e-01 12 112489176 112489988 813 + 0.343 0.450 0.593
ENSG00000179295 E032 1.9482053 0.0507716411 7.944423e-01 8.929890e-01 12 112489989 112491265 1277 + 0.434 0.446 0.066
ENSG00000179295 E033 5.7692380 0.0877627872 5.547174e-02 1.924136e-01 12 112501162 112502143 982 + 0.632 1.034 1.580
ENSG00000179295 E034 205.4099884 0.0008400289 8.133014e-01 9.042285e-01 12 112502144 112502256 113 + 2.218 2.300 0.276
ENSG00000179295 E035 1.1715316 0.5445933006 4.218209e-01   12 112502257 112504104 1848 + 0.181 0.543 2.269
ENSG00000179295 E036 0.7608862 0.2581743837 1.530423e-01   12 112504105 112504338 234 + 0.127 0.448 2.416
ENSG00000179295 E037 1.2145857 0.0264730961 1.584403e-01   12 112504339 112504694 356 + 0.227 0.533 1.812
ENSG00000179295 E038 213.4183369 0.0002238425 4.391599e-01 6.581197e-01 12 112504695 112504796 102 + 2.238 2.309 0.235
ENSG00000179295 E039 3971.8521953 0.0053987938 5.945681e-08 2.329492e-06 12 112505825 112509918 4094 + 3.470 3.662 0.639