ENSG00000179222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326587 ENSG00000179222 HEK293_OSMI2_6hA HEK293_TMG_6hB MAGED1 protein_coding protein_coding 223.0594 286.4641 138.6836 43.2101 3.778963 -1.046504 188.14023 247.974497 109.30422 39.520592 4.219836 -1.181769 0.82961250 0.8629333 0.7876667 -0.07526667 0.027943396 0.005467251 FALSE TRUE
ENST00000482188 ENSG00000179222 HEK293_OSMI2_6hA HEK293_TMG_6hB MAGED1 protein_coding processed_transcript 223.0594 286.4641 138.6836 43.2101 3.778963 -1.046504 10.76897 3.933149 17.95725 1.582188 2.721461 2.187950 0.06759583 0.0165000 0.1301000 0.11360000 0.005467251 0.005467251 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000179222 E001 0.1308682 0.0307440893 1.000000e+00   X 51803007 51803058 52 + 0.001 0.077 6.868
ENSG00000179222 E002 0.9594886 0.0178501524 5.754388e-01   X 51803059 51803073 15 + 0.186 0.295 0.857
ENSG00000179222 E003 45.9394422 0.0065504234 3.476258e-03 0.0262016106 X 51803074 51803117 44 + 1.452 1.666 0.731
ENSG00000179222 E004 1.0237200 0.0156571511 5.652785e-01   X 51884979 51885055 77 + 0.186 0.295 0.863
ENSG00000179222 E005 1.4584508 0.0126493042 7.617236e-01 0.8736581289 X 51893533 51893578 46 + 0.316 0.373 0.347
ENSG00000179222 E006 10.2320789 0.0030392134 4.940417e-01 0.6967193252 X 51893579 51893622 44 + 1.048 0.971 -0.284
ENSG00000179222 E007 90.0835863 0.0004833085 5.111575e-01 0.7088544984 X 51893623 51893638 16 + 1.884 1.912 0.094
ENSG00000179222 E008 159.6208397 0.0006114806 7.122919e-01 0.8432302292 X 51893639 51893645 7 + 2.160 2.148 -0.041
ENSG00000179222 E009 194.1081170 0.0010824749 8.290245e-01 0.9132625903 X 51893646 51893648 3 + 2.241 2.234 -0.023
ENSG00000179222 E010 395.2031930 0.0027704699 8.796100e-02 0.2599370316 X 51893649 51893657 9 + 2.584 2.528 -0.188
ENSG00000179222 E011 759.3069713 0.0004636221 2.807502e-01 0.5209960423 X 51893658 51893755 98 + 2.840 2.820 -0.066
ENSG00000179222 E012 590.5983799 0.0013733379 1.176223e-01 0.3118848200 X 51894269 51894275 7 + 2.745 2.705 -0.132
ENSG00000179222 E013 994.6056221 0.0013016936 1.796187e-01 0.4034572426 X 51894276 51894349 74 + 2.964 2.934 -0.100
ENSG00000179222 E014 2.2788164 0.0143444457 2.697430e-01 0.5096523233 X 51894569 51894598 30 + 0.316 0.523 1.125
ENSG00000179222 E015 6.0035998 0.0303646499 2.714212e-01 0.5113425337 X 51894627 51894794 168 + 0.675 0.853 0.716
ENSG00000179222 E016 4109.5206920 0.0005133487 9.266956e-06 0.0001965213 X 51895053 51895655 603 + 3.594 3.544 -0.164
ENSG00000179222 E017 1269.7637510 0.0002465279 2.930025e-01 0.5336977541 X 51895656 51895760 105 + 3.057 3.043 -0.044
ENSG00000179222 E018 11.1389432 0.0750553562 3.949965e-04 0.0046830142 X 51896153 51896322 170 + 1.362 0.803 -2.040
ENSG00000179222 E019 3540.0878958 0.0003455723 8.220562e-02 0.2491283417 X 51896409 51897077 669 + 3.480 3.498 0.059
ENSG00000179222 E020 4.0321940 0.0608306822 7.326728e-01 0.8557769791 X 51897078 51897207 130 + 0.677 0.623 -0.233
ENSG00000179222 E021 1107.0440957 0.0005673306 1.524099e-01 0.3658126327 X 51897208 51897271 64 + 3.004 2.981 -0.078
ENSG00000179222 E022 6.1837444 0.0049317462 3.218900e-01 0.5613564750 X 51897272 51897546 275 + 0.901 0.768 -0.518
ENSG00000179222 E023 1231.0652289 0.0008051364 1.142501e-01 0.3062338110 X 51897547 51897626 80 + 3.053 3.026 -0.089
ENSG00000179222 E024 1451.6045716 0.0005843295 2.183432e-01 0.4514487163 X 51897795 51897886 92 + 3.118 3.100 -0.060
ENSG00000179222 E025 18.6402325 0.0798714758 2.598066e-02 0.1152585131 X 51897887 51898113 227 + 1.470 1.117 -1.240
ENSG00000179222 E026 1369.9218928 0.0002798243 1.205278e-01 0.3166666908 X 51898114 51898193 80 + 3.095 3.075 -0.066
ENSG00000179222 E027 25.6030139 0.1097841975 4.748053e-02 0.1737103206 X 51898194 51898284 91 + 1.578 1.263 -1.089
ENSG00000179222 E028 1110.0323730 0.0003990382 5.233333e-01 0.7173566488 X 51898285 51898327 43 + 2.996 2.987 -0.032
ENSG00000179222 E029 45.0503144 0.1441284104 1.092869e-01 0.2979473350 X 51898328 51898580 253 + 1.780 1.527 -0.862
ENSG00000179222 E030 1025.4088272 0.0008292807 8.124267e-01 0.9036658822 X 51898581 51898610 30 + 2.952 2.957 0.015
ENSG00000179222 E031 1026.6379603 0.0001217196 4.545275e-01 0.6691443733 X 51898611 51898643 33 + 2.949 2.958 0.032
ENSG00000179222 E032 25.8294459 0.1366919928 8.082061e-02 0.2464571482 X 51898644 51900181 1538 + 1.566 1.278 -0.995
ENSG00000179222 E033 1807.7753311 0.0000644618 3.879511e-05 0.0006713850 X 51900182 51900296 115 + 3.170 3.211 0.135
ENSG00000179222 E034 3644.6482137 0.0007293550 7.646463e-06 0.0001661819 X 51901553 51901938 386 + 3.458 3.521 0.210
ENSG00000179222 E035 38.6476023 0.0298741491 7.360960e-01 0.8580157138 X 51901939 51902145 207 + 1.521 1.548 0.093
ENSG00000179222 E036 1393.6688185 0.0013845572 3.613852e-05 0.0006321747 X 51902146 51902354 209 + 3.019 3.110 0.300