ENSG00000179119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336349 ENSG00000179119 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTY2D1 protein_coding protein_coding 9.518355 2.113643 15.76676 0.5711443 0.6485066 2.893188 7.4132279 2.07085772 12.592428 0.54497404 0.3397405 2.598451 0.85358333 0.98493333 0.7996 -0.1853333 4.554476e-05 4.554476e-05 FALSE TRUE
ENST00000536336 ENSG00000179119 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTY2D1 protein_coding retained_intron 9.518355 2.113643 15.76676 0.5711443 0.6485066 2.893188 1.1641287 0.00000000 1.296684 0.00000000 0.3045661 7.029766 0.06903333 0.00000000 0.0832 0.0832000 4.064477e-03 4.554476e-05 FALSE TRUE
ENST00000543776 ENSG00000179119 HEK293_OSMI2_6hA HEK293_TMG_6hB SPTY2D1 protein_coding processed_transcript 9.518355 2.113643 15.76676 0.5711443 0.6485066 2.893188 0.9409989 0.04278503 1.877652 0.04278503 0.5360859 5.160320 0.07738750 0.01506667 0.1172 0.1021333 1.020736e-01 4.554476e-05   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000179119 E001 543.4450315 0.0003932953 1.399296e-08 6.352115e-07 11 18606403 18609954 3552 - 2.608 2.674 0.222
ENSG00000179119 E002 45.0361351 0.0781995351 6.290625e-01 7.898944e-01 11 18611477 18611554 78 - 1.542 1.587 0.156
ENSG00000179119 E003 0.2852693 0.2627419835 1.000000e+00   11 18612165 18612313 149 - 0.110 0.000 -8.089
ENSG00000179119 E004 79.3789901 0.0075864220 7.473819e-01 8.651378e-01 11 18612314 18612488 175 - 1.799 1.772 -0.092
ENSG00000179119 E005 271.0221742 0.0120558846 2.169907e-02 1.015823e-01 11 18614563 18615772 1210 - 2.337 2.205 -0.439
ENSG00000179119 E006 97.0126124 0.0008260255 3.175984e-03 2.446575e-02 11 18615773 18616098 326 - 1.904 1.739 -0.555
ENSG00000179119 E007 52.4868665 0.0107987379 3.532662e-01 5.901887e-01 11 18616875 18616989 115 - 1.633 1.533 -0.344
ENSG00000179119 E008 40.9497954 0.0011308421 2.366443e-01 4.726902e-01 11 18634198 18634389 192 - 1.526 1.424 -0.352
ENSG00000179119 E009 2.4028301 0.1155074038 3.265335e-01 5.657421e-01 11 18634690 18634791 102 - 0.487 0.231 -1.556