ENSG00000178921

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314666 ENSG00000178921 HEK293_OSMI2_6hA HEK293_TMG_6hB PFAS protein_coding protein_coding 62.54509 87.26981 53.28741 8.42304 2.894271 -0.7115826 38.293450 58.893125 36.422827 7.758378 0.6816308 -0.69310524 0.61479583 0.66966667 0.68676667 0.01710000 9.573640e-01 4.405329e-06 FALSE TRUE
ENST00000546020 ENSG00000178921 HEK293_OSMI2_6hA HEK293_TMG_6hB PFAS protein_coding protein_coding 62.54509 87.26981 53.28741 8.42304 2.894271 -0.7115826 7.553301 9.950459 1.935026 1.745585 0.1068619 -2.35642311 0.10808750 0.11283333 0.03633333 -0.07650000 4.405329e-06 4.405329e-06 FALSE TRUE
ENST00000580251 ENSG00000178921 HEK293_OSMI2_6hA HEK293_TMG_6hB PFAS protein_coding retained_intron 62.54509 87.26981 53.28741 8.42304 2.894271 -0.7115826 4.864095 5.319730 5.034416 1.458386 0.1695596 -0.07937527 0.08355417 0.06583333 0.09530000 0.02946667 6.905267e-01 4.405329e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178921 E001 14.3160488 0.0114059405 2.877712e-01 5.285034e-01 17 8247618 8247856 239 + 1.224 1.119 -0.377
ENSG00000178921 E002 2.6427787 0.0085221309 6.888794e-02 2.225501e-01 17 8249274 8249283 10 + 0.285 0.618 1.767
ENSG00000178921 E003 2.7854133 0.0113507410 1.788328e-01 4.023998e-01 17 8249284 8249285 2 + 0.378 0.618 1.184
ENSG00000178921 E004 3.8807097 0.0925044567 6.688002e-01 8.154218e-01 17 8249286 8249288 3 + 0.622 0.687 0.276
ENSG00000178921 E005 3.8863192 0.0250392620 9.548324e-01 9.793001e-01 17 8249289 8249290 2 + 0.671 0.663 -0.032
ENSG00000178921 E006 197.5166796 0.0004895221 5.386001e-06 1.229556e-04 17 8249291 8249339 49 + 2.345 2.225 -0.402
ENSG00000178921 E007 1.6469608 0.1153741595 4.443753e-01 6.616731e-01 17 8249342 8249505 164 + 0.285 0.449 0.966
ENSG00000178921 E008 2.4755813 0.0096680693 2.927670e-01 5.334724e-01 17 8253842 8253858 17 + 0.378 0.568 0.958
ENSG00000178921 E009 332.0566129 0.0002581276 5.511909e-09 2.740992e-07 17 8253859 8253937 79 + 2.569 2.452 -0.391
ENSG00000178921 E010 450.7425434 0.0013714557 2.481190e-06 6.305001e-05 17 8253938 8254079 142 + 2.698 2.586 -0.375
ENSG00000178921 E011 343.1022612 0.0003400760 2.977631e-03 2.326097e-02 17 8254166 8254301 136 + 2.546 2.488 -0.194
ENSG00000178921 E012 291.5674810 0.0001648342 2.424274e-05 4.501394e-04 17 8255027 8255132 106 + 2.495 2.409 -0.287
ENSG00000178921 E013 367.9348543 0.0006955387 1.848005e-03 1.604265e-02 17 8255502 8255691 190 + 2.581 2.515 -0.219
ENSG00000178921 E014 299.0480726 0.0002989459 1.482131e-05 2.951108e-04 17 8255805 8255910 106 + 2.509 2.419 -0.300
ENSG00000178921 E015 441.5961951 0.0009762389 3.230157e-06 7.906529e-05 17 8256267 8256407 141 + 2.683 2.583 -0.334
ENSG00000178921 E016 11.7208612 0.2188171386 5.649068e-02 1.947942e-01 17 8256408 8256523 116 + 1.302 0.904 -1.441
ENSG00000178921 E017 427.3466590 0.0009287175 2.957373e-05 5.330962e-04 17 8256524 8256648 125 + 2.662 2.574 -0.295
ENSG00000178921 E018 322.1925109 0.0001586078 2.709550e-01 5.109133e-01 17 8256835 8256963 129 + 2.494 2.477 -0.056
ENSG00000178921 E019 299.3302659 0.0002111881 6.361401e-01 7.944056e-01 17 8257807 8257938 132 + 2.452 2.449 -0.013
ENSG00000178921 E020 367.4131823 0.0001559482 3.282343e-02 1.355711e-01 17 8258071 8258199 129 + 2.562 2.526 -0.120
ENSG00000178921 E021 0.1723744 0.0372359458 1.000000e+00   17 8262460 8262499 40 + 0.000 0.088 7.629
ENSG00000178921 E022 346.0649487 0.0001768051 7.532508e-03 4.717485e-02 17 8262920 8262987 68 + 2.544 2.496 -0.162
ENSG00000178921 E023 220.7131670 0.0002712927 6.851770e-03 4.396207e-02 17 8262988 8262993 6 + 2.359 2.296 -0.210
ENSG00000178921 E024 513.7718339 0.0001531262 1.088760e-03 1.059154e-02 17 8263109 8263260 152 + 2.716 2.667 -0.164
ENSG00000178921 E025 207.1556269 0.0022958755 9.345535e-02 2.701194e-01 17 8263261 8263265 5 + 2.327 2.275 -0.175
ENSG00000178921 E026 324.7661304 0.0019563467 1.337608e-01 3.376940e-01 17 8263575 8263636 62 + 2.511 2.472 -0.128
ENSG00000178921 E027 501.7315420 0.0002052644 1.043891e-03 1.024543e-02 17 8263775 8263936 162 + 2.708 2.657 -0.169
ENSG00000178921 E028 367.8203209 0.0002368573 4.110314e-01 6.368443e-01 17 8264212 8264337 126 + 2.546 2.536 -0.034
ENSG00000178921 E029 256.7455705 0.0002572083 1.433931e-02 7.565253e-02 17 8264470 8264601 132 + 2.337 2.404 0.224
ENSG00000178921 E030 11.8830929 0.2662074789 1.970616e-01 4.259065e-01 17 8264602 8264641 40 + 1.221 0.998 -0.801
ENSG00000178921 E031 544.7781715 0.0001575683 1.195772e-03 1.140008e-02 17 8264895 8265125 231 + 2.666 2.729 0.208
ENSG00000178921 E032 617.4198719 0.0002676438 1.523513e-02 7.897187e-02 17 8265288 8265468 181 + 2.732 2.779 0.158
ENSG00000178921 E033 425.4357565 0.0008658030 9.908197e-01 9.971553e-01 17 8265556 8265639 84 + 2.598 2.605 0.023
ENSG00000178921 E034 488.6659097 0.0001461639 7.814715e-01 8.855130e-01 17 8265862 8265972 111 + 2.655 2.667 0.039
ENSG00000178921 E035 297.5140519 0.0002175371 6.574680e-01 8.083196e-01 17 8265973 8266005 33 + 2.450 2.447 -0.010
ENSG00000178921 E036 252.1633932 0.0003944958 2.225149e-01 4.564943e-01 17 8266006 8266017 12 + 2.393 2.370 -0.077
ENSG00000178921 E037 341.5948073 0.0001807263 6.564978e-01 8.076341e-01 17 8266234 8266271 38 + 2.510 2.508 -0.008
ENSG00000178921 E038 478.8397724 0.0005396261 5.250615e-02 1.854951e-01 17 8266272 8266353 82 + 2.622 2.668 0.152
ENSG00000178921 E039 13.2378091 0.0759111918 8.753185e-01 9.388973e-01 17 8266501 8266752 252 + 1.130 1.126 -0.017
ENSG00000178921 E040 614.0752903 0.0009707773 3.812331e-03 2.809257e-02 17 8266753 8266898 146 + 2.714 2.780 0.220
ENSG00000178921 E041 51.2105088 0.0663542898 1.725176e-01 3.938201e-01 17 8266899 8267027 129 + 1.791 1.629 -0.550
ENSG00000178921 E042 737.9788660 0.0001433020 1.792905e-09 9.973028e-08 17 8267028 8267226 199 + 2.773 2.869 0.321
ENSG00000178921 E043 276.2028813 0.0003192017 3.129273e-04 3.860119e-03 17 8267227 8267235 9 + 2.346 2.441 0.316
ENSG00000178921 E044 512.4330973 0.0002129848 1.893626e-03 1.636213e-02 17 8267372 8267463 92 + 2.640 2.703 0.209
ENSG00000178921 E045 570.7375942 0.0001258915 3.622190e-05 6.335028e-04 17 8267551 8267665 115 + 2.677 2.752 0.250
ENSG00000178921 E046 763.3707174 0.0011252051 8.499882e-07 2.467058e-05 17 8268533 8268856 324 + 2.775 2.885 0.366
ENSG00000178921 E047 14.5498239 0.0196638102 7.855005e-01 8.878273e-01 17 8268857 8268953 97 + 1.186 1.159 -0.094
ENSG00000178921 E048 2403.1992926 0.0011091388 5.806024e-05 9.476179e-04 17 8268954 8270491 1538 + 3.302 3.373 0.236