ENSG00000178904

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342179 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding protein_coding 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 0.9217696 0.1550437 1.32839373 0.07912362 0.25899031 3.019583 0.10119583 0.05166667 0.149100000 0.09743333 0.51476958 0.03692369 FALSE TRUE
ENST00000392250 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding protein_coding 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 2.6520289 0.6368393 3.80054991 0.32578677 0.35968082 2.558520 0.25424583 0.17656667 0.419833333 0.24326667 0.60243467 0.03692369 FALSE TRUE
ENST00000592142 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding retained_intron 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 0.8098798 0.3900903 1.06465566 0.05558687 0.15173891 1.425477 0.09754167 0.12190000 0.118000000 -0.00390000 0.99891337 0.03692369 FALSE TRUE
ENST00000592503 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding processed_transcript 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 0.6445624 0.1739993 0.08719255 0.17399935 0.08719255 -0.920783 0.08005417 0.06400000 0.009066667 -0.05493333 0.94842297 0.03692369 FALSE FALSE
ENST00000592832 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding nonsense_mediated_decay 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 0.3915773 0.0000000 0.99823050 0.00000000 0.50107289 6.655682 0.03432083 0.00000000 0.106666667 0.10666667 0.41690332 0.03692369 TRUE FALSE
ENST00000608291 ENSG00000178904 HEK293_OSMI2_6hA HEK293_TMG_6hB DPY19L3 protein_coding retained_intron 7.588568 3.303398 9.014118 0.3483431 0.3709517 1.445474 0.8629467 1.4418259 0.36912820 0.22347863 0.23940020 -1.937111 0.24150417 0.43260000 0.041566667 -0.39103333 0.03692369 0.03692369 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178904 E001 0.0000000       19 32405543 32405748 206 +      
ENSG00000178904 E002 0.5470056 0.154864874 0.4235540672   19 32405749 32405769 21 + 0.123 0.349 1.914
ENSG00000178904 E003 1.3568450 0.170597470 0.0568620488   19 32405770 32405781 12 + 0.173 0.674 2.928
ENSG00000178904 E004 6.0320996 0.140239001 0.0583157969 0.199010582 19 32405782 32405859 78 + 0.608 1.138 2.061
ENSG00000178904 E005 5.4673084 0.088754270 0.1297565978 0.331447960 19 32405860 32405879 20 + 0.627 1.036 1.608
ENSG00000178904 E006 6.4495376 0.004988896 0.1069629049 0.293937690 19 32405880 32405909 30 + 0.710 1.067 1.371
ENSG00000178904 E007 1.9441867 0.411733418 0.6649791793 0.813016171 19 32406125 32406188 64 + 0.342 0.563 1.151
ENSG00000178904 E008 3.6567775 0.180425962 0.4364365922 0.656087012 19 32406189 32406302 114 + 0.602 0.556 -0.207
ENSG00000178904 E009 18.2903805 0.005956896 0.4218098127 0.645022807 19 32408217 32408356 140 + 1.183 1.284 0.357
ENSG00000178904 E010 21.6764177 0.045799705 0.0233563701 0.107059539 19 32411239 32411372 134 + 1.296 1.183 -0.400
ENSG00000178904 E011 2.7355526 0.032123809 0.0193203564 0.093564512 19 32411373 32413187 1815 + 0.335 0.862 2.434
ENSG00000178904 E012 0.9349259 0.021228697 0.2842117583   19 32427997 32428061 65 + 0.175 0.460 1.923
ENSG00000178904 E013 17.3920209 0.070390328 0.0147253873 0.077051593 19 32432716 32432806 91 + 1.219 1.012 -0.746
ENSG00000178904 E014 17.3631732 0.026229160 0.0684888452 0.221707195 19 32436446 32436567 122 + 1.188 1.152 -0.128
ENSG00000178904 E015 27.5116531 0.017596359 0.0137721729 0.073432707 19 32437194 32437339 146 + 1.383 1.325 -0.201
ENSG00000178904 E016 3.6026268 0.320025242 0.6542324594 0.806215261 19 32438979 32439111 133 + 0.533 0.742 0.907
ENSG00000178904 E017 12.8427978 0.054735692 0.1384907990 0.345235974 19 32439112 32439116 5 + 1.070 1.019 -0.188
ENSG00000178904 E018 29.8925751 0.023832018 0.0101435289 0.058747852 19 32439117 32439216 100 + 1.422 1.338 -0.294
ENSG00000178904 E019 20.1478193 0.030139244 0.0022205798 0.018526432 19 32439217 32439235 19 + 1.279 1.069 -0.745
ENSG00000178904 E020 24.8211207 0.034937525 0.0010411837 0.010225361 19 32439776 32439819 44 + 1.365 1.137 -0.805
ENSG00000178904 E021 27.2586308 0.046326666 0.0018268654 0.015890379 19 32439820 32439910 91 + 1.404 1.176 -0.799
ENSG00000178904 E022 25.3957164 0.037210817 0.0166349527 0.084107677 19 32453145 32453276 132 + 1.359 1.252 -0.373
ENSG00000178904 E023 17.8208853 0.059553158 0.1249437530 0.323642455 19 32454939 32455040 102 + 1.198 1.157 -0.145
ENSG00000178904 E024 0.0000000       19 32458098 32458099 2 +      
ENSG00000178904 E025 17.1359138 0.106123219 0.4335435080 0.653915546 19 32458100 32458173 74 + 1.158 1.229 0.250
ENSG00000178904 E026 17.3883200 0.018323424 0.0340878044 0.139099243 19 32458351 32458403 53 + 1.196 1.133 -0.222
ENSG00000178904 E027 20.7981509 0.017520582 0.0140462076 0.074520133 19 32458404 32458468 65 + 1.274 1.189 -0.299
ENSG00000178904 E028 19.2109770 0.015231742 0.0029395990 0.023032736 19 32458469 32458509 41 + 1.255 1.110 -0.515
ENSG00000178904 E029 28.6845309 0.034010893 0.0024624587 0.020086561 19 32463366 32463488 123 + 1.420 1.263 -0.546
ENSG00000178904 E030 32.7568798 0.007556378 0.0004459179 0.005184303 19 32463869 32463980 112 + 1.468 1.361 -0.372
ENSG00000178904 E031 27.7345079 0.013785328 0.0009571336 0.009561934 19 32464728 32464784 57 + 1.403 1.268 -0.468
ENSG00000178904 E032 7.2951853 0.005036266 0.7928356335 0.892062193 19 32467474 32467626 153 + 0.799 0.992 0.735
ENSG00000178904 E033 23.9607568 0.124620383 0.7510482046 0.867412893 19 32467627 32468730 1104 + 1.246 1.499 0.877
ENSG00000178904 E034 27.4231941 0.037604554 0.1312055539 0.333712280 19 32468731 32468813 83 + 1.366 1.375 0.031
ENSG00000178904 E035 0.6542209 0.019387492 0.3746667478   19 32468990 32469119 130 + 0.124 0.354 1.928
ENSG00000178904 E036 1.2668629 0.030615426 0.0083316324   19 32477483 32477521 39 + 0.124 0.679 3.517
ENSG00000178904 E037 34.0134637 0.011798157 0.2488271508 0.486613847 19 32477522 32477654 133 + 1.440 1.528 0.303
ENSG00000178904 E038 30.7002495 0.039437659 0.4856345416 0.691003132 19 32480399 32480557 159 + 1.361 1.594 0.800
ENSG00000178904 E039 0.6600180 0.023487245 0.2169215069   19 32480705 32480756 52 + 0.221 0.000 -25.947
ENSG00000178904 E040 1.3496583 0.020025659 0.6634761800   19 32481041 32481138 98 + 0.334 0.353 0.118
ENSG00000178904 E041 5.1636080 0.144216154 0.1496249126 0.361718969 19 32481139 32481940 802 + 0.580 1.022 1.765
ENSG00000178904 E042 370.1077564 1.769063274 0.3607143567 0.596202872 19 32482079 32485895 3817 + 2.355 2.772 1.390