ENSG00000178821

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310991 ENSG00000178821 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM52 protein_coding protein_coding 10.40876 13.74539 5.001752 1.895081 0.4305185 -1.456611 0.7062808 0.3439609 1.10211091 0.22824451 0.55492067 1.651639 0.08065000 0.0220000 0.240566667 0.21856667 0.6935818234 0.0007908324 FALSE  
ENST00000378602 ENSG00000178821 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM52 protein_coding protein_coding 10.40876 13.74539 5.001752 1.895081 0.4305185 -1.456611 4.1126480 5.6696926 3.01923988 0.35333427 0.36612647 -0.906857 0.41447083 0.4322000 0.600400000 0.16820000 0.4448071895 0.0007908324 FALSE  
ENST00000470931 ENSG00000178821 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM52 protein_coding nonsense_mediated_decay 10.40876 13.74539 5.001752 1.895081 0.4305185 -1.456611 0.6639362 1.2425565 0.04002555 0.07550746 0.04002555 -4.646067 0.05915833 0.0922000 0.006833333 -0.08536667 0.0007908324 0.0007908324 FALSE  
MSTRG.121.1 ENSG00000178821 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM52 protein_coding   10.40876 13.74539 5.001752 1.895081 0.4305185 -1.456611 3.0577092 4.4197375 0.51368765 1.04784974 0.51368765 -3.080443 0.26747083 0.3137667 0.087766667 -0.22600000 0.2618234876 0.0007908324 FALSE  
MSTRG.121.5 ENSG00000178821 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM52 protein_coding   10.40876 13.74539 5.001752 1.895081 0.4305185 -1.456611 1.0154704 1.4824228 0.09689332 0.53956602 0.09689332 -3.803413 0.09877917 0.1024333 0.021733333 -0.08070000 0.2923850923 0.0007908324 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178821 E001 0.3336024 3.1646955231 0.7321259790   1 1917590 1917590 1 - 0.001 0.118 7.902
ENSG00000178821 E002 58.5137616 0.0011449130 0.3416773686 0.579474108 1 1917591 1917844 254 - 1.619 1.682 0.213
ENSG00000178821 E003 29.6447129 0.0015716450 0.7582497399 0.871521990 1 1917845 1917850 6 - 1.355 1.389 0.117
ENSG00000178821 E004 65.0965976 0.0081731517 0.3030906963 0.543656551 1 1917851 1917936 86 - 1.759 1.702 -0.194
ENSG00000178821 E005 84.3129497 0.0005657739 0.0369100135 0.146709464 1 1917937 1918071 135 - 1.897 1.812 -0.286
ENSG00000178821 E006 45.7757771 0.0012925490 0.2052205329 0.436168436 1 1918072 1918098 27 - 1.626 1.553 -0.250
ENSG00000178821 E007 54.6345687 0.0008038032 0.2646489912 0.503941129 1 1918099 1918162 64 - 1.691 1.634 -0.193
ENSG00000178821 E008 56.6600638 0.0008812353 0.8293174145 0.913406088 1 1918253 1918385 133 - 1.647 1.665 0.063
ENSG00000178821 E009 28.9862435 0.0013429266 0.1603294604 0.377291660 1 1918386 1918431 46 - 1.270 1.397 0.444
ENSG00000178821 E010 47.7045222 0.0013395612 0.0622555002 0.207863056 1 1918432 1918892 461 - 1.672 1.565 -0.363
ENSG00000178821 E011 10.0084525 0.0461285414 0.4029178955 0.630681935 1 1918893 1918934 42 - 0.804 0.984 0.685
ENSG00000178821 E012 8.9675264 0.0103126735 0.0287161244 0.123503480 1 1918935 1919044 110 - 0.569 0.965 1.604
ENSG00000178821 E013 13.5008858 0.0237479062 0.0005839707 0.006438464 1 1919045 1919088 44 - 0.481 1.138 2.651
ENSG00000178821 E014 6.3129812 0.0769972537 0.0328006019 0.135497364 1 1919089 1919181 93 - 0.224 0.848 3.161
ENSG00000178821 E015 8.7477963 0.0609567925 0.0524367769 0.185327175 1 1919182 1919279 98 - 0.481 0.959 2.001