ENSG00000178719

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395068 ENSG00000178719 HEK293_OSMI2_6hA HEK293_TMG_6hB GRINA protein_coding protein_coding 141.9666 189.7627 71.37702 33.0374 1.693488 -1.410539 49.704713 76.652061 16.086155 14.6738576 2.4158101 -2.251797 0.34575417 0.40086667 0.2254000 -0.17546667 0.02581617 8.353045e-06 FALSE TRUE
ENST00000534791 ENSG00000178719 HEK293_OSMI2_6hA HEK293_TMG_6hB GRINA protein_coding protein_coding 141.9666 189.7627 71.37702 33.0374 1.693488 -1.410539 10.092061 13.831626 8.521211 1.0561681 0.7780517 -0.698191 0.08269583 0.07640000 0.1193333 0.04293333 0.31346276 8.353045e-06 FALSE TRUE
MSTRG.32239.4 ENSG00000178719 HEK293_OSMI2_6hA HEK293_TMG_6hB GRINA protein_coding   141.9666 189.7627 71.37702 33.0374 1.693488 -1.410539 58.503482 82.160741 28.310273 15.6887703 1.4515452 -1.536790 0.39888333 0.42983333 0.3975667 -0.03226667 0.83844809 8.353045e-06 FALSE FALSE
MSTRG.32239.7 ENSG00000178719 HEK293_OSMI2_6hA HEK293_TMG_6hB GRINA protein_coding   141.9666 189.7627 71.37702 33.0374 1.693488 -1.410539 6.972923 1.872526 15.004481 0.9717122 4.8332911 2.995613 0.06747083 0.01196667 0.2092333 0.19726667 0.17959987 8.353045e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178719 E001 0.0000000       8 143990056 143990057 2 +      
ENSG00000178719 E002 0.1426347 3.223167e-02 1.473261e-01   8 143990058 143990064 7 + 0.195 0.000 -11.404
ENSG00000178719 E003 1.2862641 1.383391e-02 4.074360e-01   8 143990065 143990065 1 + 0.432 0.282 -0.898
ENSG00000178719 E004 5.0371851 5.880271e-03 4.293913e-02 1.623739e-01 8 143990066 143990082 17 + 0.432 0.787 1.585
ENSG00000178719 E005 122.5222941 4.902046e-01 5.818070e-02 1.986793e-01 8 143990083 143990199 117 + 1.558 2.105 1.845
ENSG00000178719 E006 20.5521397 1.842201e-03 6.211254e-06 1.389192e-04 8 143990200 143990286 87 + 0.861 1.356 1.795
ENSG00000178719 E007 20.4218345 2.101504e-03 2.039642e-04 2.718611e-03 8 143990287 143990311 25 + 0.952 1.342 1.398
ENSG00000178719 E008 0.3751086 3.222044e-02 7.517704e-01   8 143990441 143990486 46 + 0.000 0.136 11.450
ENSG00000178719 E009 2.2270165 2.288516e-01 5.044462e-01 7.038955e-01 8 143990677 143990907 231 + 0.331 0.488 0.862
ENSG00000178719 E010 238.6187583 2.417836e-02 9.872320e-03 5.758362e-02 8 143991200 143991293 94 + 2.149 2.352 0.679
ENSG00000178719 E011 314.2150227 4.541739e-03 2.957939e-02 1.261144e-01 8 143991294 143991453 160 + 2.364 2.452 0.295
ENSG00000178719 E012 233.3648878 2.165152e-04 4.023545e-01 6.302721e-01 8 143991454 143991532 79 + 2.284 2.312 0.095
ENSG00000178719 E013 153.1472703 3.279467e-04 2.931124e-01 5.338261e-01 8 143991533 143991555 23 + 2.146 2.117 -0.096
ENSG00000178719 E014 347.8359713 2.581901e-04 2.859489e-01 5.265974e-01 8 143991556 143991602 47 + 2.491 2.473 -0.062
ENSG00000178719 E015 4.7450134 2.296665e-01 1.306819e-01 3.328502e-01 8 143991603 143991691 89 + 0.929 0.596 -1.346
ENSG00000178719 E016 610.5619126 6.036334e-04 6.472079e-01 8.016007e-01 8 143991692 143991746 55 + 2.723 2.718 -0.016
ENSG00000178719 E017 818.9848788 8.912948e-04 7.175905e-02 2.283283e-01 8 143991747 143991804 58 + 2.870 2.840 -0.098
ENSG00000178719 E018 11.4181434 1.003289e-01 4.834819e-01 6.894190e-01 8 143991805 143991877 73 + 1.115 1.000 -0.418
ENSG00000178719 E019 951.8352524 6.155319e-04 9.881195e-05 1.479635e-03 8 143991878 143991949 72 + 2.957 2.896 -0.205
ENSG00000178719 E020 677.0596983 5.713024e-04 1.719813e-06 4.569208e-05 8 143991950 143991955 6 + 2.827 2.741 -0.285
ENSG00000178719 E021 1402.9503876 6.798002e-05 4.298275e-06 1.010026e-04 8 143991956 143992078 123 + 3.115 3.071 -0.145
ENSG00000178719 E022 73.6808747 2.992251e-02 4.433331e-02 1.659159e-01 8 143992079 143992173 95 + 1.947 1.748 -0.670
ENSG00000178719 E023 64.6606542 1.510090e-02 3.528358e-02 1.423316e-01 8 143992174 143992244 71 + 1.871 1.705 -0.561
ENSG00000178719 E024 1310.6714477 1.143497e-04 1.680761e-01 3.880100e-01 8 143992245 143992373 129 + 3.061 3.050 -0.037
ENSG00000178719 E025 1516.4994166 2.691126e-04 8.786793e-01 9.406022e-01 8 143992465 143992608 144 + 3.112 3.117 0.017
ENSG00000178719 E026 2420.3880597 7.010472e-05 2.258328e-16 4.101776e-14 8 143992692 143993415 724 + 3.262 3.335 0.243