ENSG00000178209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356346 ENSG00000178209 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEC protein_coding protein_coding 10.1177 15.03045 6.198125 1.054518 0.1951762 -1.276618 4.8224661 7.8477228 2.7082839 0.86558395 0.30710889 -1.5314152 0.4745250 0.51973333 0.4348667 -0.08486667 0.630382473 0.001969771 FALSE TRUE
ENST00000527096 ENSG00000178209 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEC protein_coding protein_coding 10.1177 15.03045 6.198125 1.054518 0.1951762 -1.276618 0.4986025 0.3909652 0.7515766 0.01146107 0.13684353 0.9255121 0.0577250 0.02633333 0.1228333 0.09650000 0.001969771 0.001969771 FALSE TRUE
ENST00000527303 ENSG00000178209 HEK293_OSMI2_6hA HEK293_TMG_6hB PLEC protein_coding protein_coding 10.1177 15.03045 6.198125 1.054518 0.1951762 -1.276618 4.4868680 6.5648251 2.5786531 0.39996308 0.06634742 -1.3447509 0.4367042 0.43850000 0.4161667 -0.02233333 0.938692835 0.001969771 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178209 E001 448.6376491 0.9969127620 2.515690e-01 0.4896189852 8 143915153 143916176 1024 - 2.233 2.713 1.601
ENSG00000178209 E002 871.0343314 1.3067974579 3.346223e-01 0.5732134058 8 143916177 143918083 1907 - 2.565 2.994 1.427
ENSG00000178209 E003 132.0823606 0.3696394517 2.070158e-01 0.4382070411 8 143918084 143918342 259 - 1.798 2.170 1.248
ENSG00000178209 E004 83.4222451 0.1760324821 1.018476e-01 0.2850842364 8 143918343 143918438 96 - 1.562 1.980 1.412
ENSG00000178209 E005 143.2413897 0.4025374913 2.111421e-01 0.4431194231 8 143918439 143918666 228 - 1.830 2.205 1.260
ENSG00000178209 E006 1007.9958725 1.4941467292 5.220954e-01 0.7163814776 8 143918667 143922107 3441 - 2.760 3.032 0.906
ENSG00000178209 E007 22.9668038 0.0015475702 4.642974e-04 0.0053489161 8 143922108 143922109 2 - 0.918 1.454 1.914
ENSG00000178209 E008 91.9587966 0.2561838202 1.978614e-01 0.4269797637 8 143922110 143922395 286 - 1.652 2.013 1.217
ENSG00000178209 E009 477.8150827 1.1679395039 4.578120e-01 0.6716224263 8 143922504 143925884 3381 - 2.417 2.713 0.986
ENSG00000178209 E010 62.2138798 0.1997446913 3.737139e-01 0.6071192690 8 143926784 143926882 99 - 1.575 1.827 0.854
ENSG00000178209 E011 59.8374740 0.2276685425 5.543563e-01 0.7393638136 8 143926977 143927081 105 - 1.612 1.796 0.624
ENSG00000178209 E012 48.9992612 0.1602078065 5.855583e-01 0.7606467352 8 143927252 143927335 84 - 1.530 1.711 0.615
ENSG00000178209 E013 69.7843489 0.2550443208 4.451923e-01 0.6622065759 8 143927410 143927766 357 - 1.651 1.869 0.737
ENSG00000178209 E014 48.4074748 0.1171603813 4.621516e-01 0.6746145110 8 143927854 143927992 139 - 1.485 1.717 0.789
ENSG00000178209 E015 63.8673810 0.0085541002 9.334498e-01 0.9688792704 8 143929103 143929281 179 - 1.624 1.836 0.717
ENSG00000178209 E016 55.2249214 0.0216418201 1.861935e-01 0.4120474856 8 143929414 143929571 158 - 1.639 1.744 0.357
ENSG00000178209 E017 58.5285076 0.0577410945 1.211545e-01 0.3176950397 8 143929646 143929829 184 - 1.710 1.751 0.138
ENSG00000178209 E018 47.0903375 0.0739058115 7.733749e-02 0.2395084430 8 143929936 143930062 127 - 1.657 1.643 -0.048
ENSG00000178209 E019 45.6691780 0.0715198520 1.606457e-01 0.3777478769 8 143930144 143930298 155 - 1.608 1.645 0.127
ENSG00000178209 E020 45.2325396 0.0009763999 1.363202e-04 0.0019369405 8 143930384 143930536 153 - 1.650 1.625 -0.086
ENSG00000178209 E021 44.3158894 0.0295780760 2.458748e-02 0.1109389538 8 143931534 143931659 126 - 1.621 1.622 0.002
ENSG00000178209 E022 36.0916335 0.0374475098 3.036258e-02 0.1284378137 8 143931937 143932032 96 - 1.543 1.536 -0.023
ENSG00000178209 E023 47.9153522 0.1147312194 5.634153e-02 0.1944259124 8 143932130 143932234 105 - 1.712 1.625 -0.297
ENSG00000178209 E024 56.8844190 0.1109947927 4.209934e-02 0.1601611994 8 143932400 143932561 162 - 1.793 1.694 -0.337
ENSG00000178209 E025 35.3198776 0.0758639516 2.773302e-02 0.1205016611 8 143932635 143932712 78 - 1.580 1.500 -0.272
ENSG00000178209 E026 81.0361814 0.1120128118 1.067220e-01 0.2935415939 8 143932793 143933111 319 - 1.899 1.868 -0.105
ENSG00000178209 E027 56.0144638 0.1669670151 1.357446e-01 0.3409474611 8 143933197 143933351 155 - 1.767 1.696 -0.238
ENSG00000178209 E028 43.9525938 0.2031119295 1.114624e-01 0.3014440983 8 143933998 143934091 94 - 1.706 1.570 -0.465
ENSG00000178209 E029 51.7680275 0.1449512615 7.466456e-02 0.2341210042 8 143934318 143934445 128 - 1.759 1.649 -0.372
ENSG00000178209 E030 45.5577669 0.1100459420 2.483930e-02 0.1117366959 8 143934635 143934730 96 - 1.728 1.581 -0.498
ENSG00000178209 E031 57.4402148 0.0817057752 4.825872e-03 0.0336748179 8 143934810 143934929 120 - 1.847 1.668 -0.604
ENSG00000178209 E032 21.2812960 0.0778149954 3.327108e-03 0.0253550845 8 143935011 143935022 12 - 1.454 1.232 -0.772
ENSG00000178209 E033 51.6275689 0.0433616747 2.983814e-04 0.0037133243 8 143935023 143935117 95 - 1.799 1.626 -0.586
ENSG00000178209 E034 55.6305565 0.0751062056 5.171891e-03 0.0355244320 8 143935198 143935313 116 - 1.818 1.666 -0.516
ENSG00000178209 E035 56.9545920 0.0600615390 2.217592e-04 0.0029135401 8 143935848 143936014 167 - 1.874 1.644 -0.779
ENSG00000178209 E036 41.2048582 0.0707687513 1.275571e-04 0.0018300354 8 143936979 143937071 93 - 1.770 1.481 -0.982
ENSG00000178209 E037 40.9224928 0.0646420183 1.286215e-04 0.0018437488 8 143937165 143937242 78 - 1.758 1.486 -0.926
ENSG00000178209 E038 0.7796672 0.0172671820 3.640190e-01   8 143937664 143937748 85 - 0.295 0.216 -0.594
ENSG00000178209 E039 0.8321321 0.6323107350 8.809993e-01   8 143937749 143937784 36 - 0.169 0.276 0.896
ENSG00000178209 E040 39.1618452 0.0997705550 1.429535e-03 0.0131105409 8 143938151 143938240 90 - 1.742 1.465 -0.943
ENSG00000178209 E041 0.0000000       8 143938401 143938415 15 -      
ENSG00000178209 E042 32.7388743 0.1303628827 3.808875e-03 0.0280731994 8 143938631 143938692 62 - 1.668 1.388 -0.958
ENSG00000178209 E043 0.1723744 0.0395000583 1.000000e+00   8 143939350 143939597 248 - 0.000 0.084 24.203
ENSG00000178209 E044 0.0000000       8 143942392 143942524 133 -      
ENSG00000178209 E045 0.7254668 0.1315733181 8.574798e-01   8 143943779 143943958 180 - 0.173 0.218 0.421
ENSG00000178209 E046 0.0000000       8 143944648 143944737 90 -      
ENSG00000178209 E047 0.0000000       8 143946350 143946384 35 -      
ENSG00000178209 E048 0.3447487 0.4291801104 1.000000e+00   8 143946385 143946547 163 - 0.000 0.157 25.232
ENSG00000178209 E049 1.9277384 0.2178681422 1.789528e-01 0.4025791965 8 143950184 143950876 693 - 0.541 0.393 -0.754
ENSG00000178209 E050 0.0000000       8 143953726 143953920 195 -      
ENSG00000178209 E051 0.1308682 0.0331124577 1.000000e+00   8 143958595 143958799 205 - 0.000 0.084 24.198
ENSG00000178209 E052 15.5337913 0.0025707819 3.379087e-05 0.0005970728 8 143973403 143973538 136 - 1.310 1.121 -0.666
ENSG00000178209 E053 22.7125990 0.0666996274 2.517753e-02 0.1127415595 8 143975177 143975375 199 - 1.395 1.313 -0.286
ENSG00000178209 E054 9.6481214 0.0050728750 3.495639e-01 0.5868675216 8 143976703 143976991 289 - 0.943 1.010 0.249