ENSG00000178177

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326877 ENSG00000178177 HEK293_OSMI2_6hA HEK293_TMG_6hB LCORL protein_coding protein_coding 4.622399 2.492498 8.515453 0.9152705 0.8123177 1.768407 0.6137609 0.47351456 1.5625850 0.16174267 0.01384655 1.701507 0.14847083 0.21096667 0.18653333 -0.02443333 0.994893514 0.005487368 FALSE TRUE
ENST00000382226 ENSG00000178177 HEK293_OSMI2_6hA HEK293_TMG_6hB LCORL protein_coding protein_coding 4.622399 2.492498 8.515453 0.9152705 0.8123177 1.768407 0.3339321 0.02379976 0.7359081 0.02379976 0.07629990 4.463913 0.05549583 0.00990000 0.08653333 0.07663333 0.005487368 0.005487368 FALSE TRUE
ENST00000510121 ENSG00000178177 HEK293_OSMI2_6hA HEK293_TMG_6hB LCORL protein_coding processed_transcript 4.622399 2.492498 8.515453 0.9152705 0.8123177 1.768407 0.2875832 0.20009226 1.0005224 0.20009226 1.00052238 2.266006 0.07480417 0.04856667 0.09866667 0.05010000 0.922857932 0.005487368 FALSE FALSE
ENST00000676061 ENSG00000178177 HEK293_OSMI2_6hA HEK293_TMG_6hB LCORL protein_coding nonsense_mediated_decay 4.622399 2.492498 8.515453 0.9152705 0.8123177 1.768407 0.3054458 0.05365224 0.3485199 0.02737216 0.15685084 2.493770 0.05358333 0.03210000 0.04210000 0.01000000 0.952931615 0.005487368 FALSE TRUE
MSTRG.24676.8 ENSG00000178177 HEK293_OSMI2_6hA HEK293_TMG_6hB LCORL protein_coding   4.622399 2.492498 8.515453 0.9152705 0.8123177 1.768407 2.0645565 1.51926879 3.1950901 0.57321596 0.36039549 1.067523 0.46672500 0.60616667 0.37870000 -0.22746667 0.096250030 0.005487368 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178177 E001 1.4073026 0.6968006291 4.346307e-01 6.547123e-01 4 17841187 17841198 12 - 0.392 0.000 -10.906
ENSG00000178177 E002 18.8594604 0.1462469915 5.636054e-01 7.458419e-01 4 17841199 17841772 574 - 1.220 1.223 0.012
ENSG00000178177 E003 11.9612235 0.0496802980 3.603863e-01 5.960213e-01 4 17841773 17841879 107 - 1.011 1.116 0.380
ENSG00000178177 E004 114.1256149 0.0415311709 4.246263e-01 6.469993e-01 4 17841880 17845074 3195 - 1.975 2.015 0.135
ENSG00000178177 E005 30.6582093 0.0444253540 3.751911e-01 6.083288e-01 4 17845075 17845496 422 - 1.446 1.332 -0.394
ENSG00000178177 E006 12.8843407 0.0371952084 6.020213e-01 7.714957e-01 4 17845497 17845639 143 - 1.049 1.119 0.251
ENSG00000178177 E007 47.9775819 0.0021684133 2.916640e-03 2.290087e-02 4 17845640 17845901 262 - 1.571 1.744 0.586
ENSG00000178177 E008 0.0000000       4 17864778 17865166 389 -      
ENSG00000178177 E009 0.1779838 0.0394684790 1.000000e+00   4 17865167 17865517 351 - 0.069 0.000 -9.507
ENSG00000178177 E010 0.6659874 0.0271975306 9.167410e-01   4 17866999 17867025 27 - 0.180 0.206 0.242
ENSG00000178177 E011 39.1389943 0.0160759306 4.326028e-02 1.632285e-01 4 17873388 17876834 3447 - 1.565 1.368 -0.678
ENSG00000178177 E012 2.4747664 0.1626298050 1.723250e-01 3.936290e-01 4 17876835 17876939 105 - 0.551 0.204 -2.089
ENSG00000178177 E013 11.6247854 0.0029086827 9.698551e-05 1.457555e-03 4 17876940 17878213 1274 - 1.109 0.535 -2.287
ENSG00000178177 E014 0.1308682 0.0326491905 1.202266e-01   4 17880595 17880628 34 - 0.000 0.206 12.717
ENSG00000178177 E015 0.1308682 0.0326491905 1.202266e-01   4 17880629 17880645 17 - 0.000 0.206 12.717
ENSG00000178177 E016 54.5746814 0.0008523222 3.356745e-07 1.090175e-05 4 17880646 17884274 3629 - 1.724 1.402 -1.101
ENSG00000178177 E017 12.9231465 0.0029687353 7.970812e-05 1.237605e-03 4 17884275 17884752 478 - 1.152 0.605 -2.123
ENSG00000178177 E018 19.8596559 0.0019345299 5.067250e-02 1.812570e-01 4 17886068 17886161 94 - 1.283 1.097 -0.660
ENSG00000178177 E019 1.3985389 0.0411891156 3.558598e-02 1.431591e-01 4 17892292 17893583 1292 - 0.226 0.606 2.149
ENSG00000178177 E020 57.7334827 0.0007427102 1.728720e-02 8.648844e-02 4 17909094 17909345 252 - 1.664 1.785 0.411
ENSG00000178177 E021 0.3088520 0.0247931994 3.508625e-01   4 17960246 17960264 19 - 0.069 0.206 1.818
ENSG00000178177 E022 1.7131880 0.0121989077 2.893685e-01 5.299124e-01 4 17960265 17960311 47 - 0.343 0.535 1.014
ENSG00000178177 E023 45.6361411 0.0008876708 6.254584e-01 7.875748e-01 4 17961903 17962032 130 - 1.588 1.619 0.105
ENSG00000178177 E024 29.4731959 0.0012759962 3.770245e-01 6.098723e-01 4 17962970 17963049 80 - 1.395 1.461 0.226
ENSG00000178177 E025 24.8806820 0.0017528151 1.027326e-01 2.866599e-01 4 17972820 17972885 66 - 1.313 1.441 0.445
ENSG00000178177 E026 0.1779838 0.0394684790 1.000000e+00   4 18020531 18020734 204 - 0.069 0.000 -9.507
ENSG00000178177 E027 11.7687738 0.0097083117 1.348283e-01 3.394137e-01 4 18021598 18021601 4 - 1.003 1.172 0.613
ENSG00000178177 E028 17.9097966 0.0031831198 4.712787e-02 1.728458e-01 4 18021602 18021876 275 - 1.168 1.346 0.625