ENSG00000178149

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313778 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding protein_coding 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 1.6980967 1.307109 0.2442728 0.6539840 0.24427281 -2.37292571 0.07555417 0.04440000 0.02400000 -0.02040000 7.817410e-01 5.364777e-11 FALSE TRUE
ENST00000341949 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding protein_coding 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 1.4708362 3.622077 0.0000000 1.8625285 0.00000000 -8.50465107 0.04791667 0.10906667 0.00000000 -0.10906667 4.223932e-01 5.364777e-11 FALSE TRUE
ENST00000438585 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding protein_coding 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 2.8659729 2.504357 0.0000000 0.7250639 0.00000000 -7.97404545 0.09316250 0.07936667 0.00000000 -0.07936667 4.226373e-07 5.364777e-11 FALSE TRUE
ENST00000440857 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding protein_coding 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 0.5958415 1.853200 0.0000000 0.4003280 0.00000000 -7.54163867 0.02271250 0.05993333 0.00000000 -0.05993333 3.694916e-09 5.364777e-11 FALSE TRUE
ENST00000441576 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding protein_coding 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 0.3987004 0.000000 0.6252243 0.0000000 0.34120294 5.98919414 0.02868750 0.00000000 0.06533333 0.06533333 1.432260e-01 5.364777e-11 FALSE TRUE
ENST00000467457 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding retained_intron 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 2.0500321 2.377765 2.2500949 0.5588144 0.15420444 -0.07927734 0.10336250 0.08293333 0.23076667 0.14783333 4.941605e-02 5.364777e-11 FALSE TRUE
ENST00000484831 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding retained_intron 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 1.7764268 2.347430 1.2605204 0.5694167 0.39668920 -0.89179560 0.08926667 0.07913333 0.12943333 0.05030000 7.815477e-01 5.364777e-11 FALSE TRUE
ENST00000498498 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding retained_intron 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 5.3734557 6.783238 3.1855696 0.1221757 0.12013045 -1.08802627 0.25923333 0.22956667 0.32626667 0.09670000 3.242182e-01 5.364777e-11 TRUE TRUE
ENST00000498794 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding retained_intron 22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 0.9848132 1.301103 0.8498980 0.2693483 0.05479483 -0.60854341 0.05427500 0.04570000 0.08693333 0.04123333 3.782010e-01 5.364777e-11 FALSE TRUE
MSTRG.22933.19 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding   22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 1.3432833 1.870117 0.1076533 0.4028045 0.10765331 -3.99820843 0.06399583 0.06023333 0.01056667 -0.04966667 2.046440e-01 5.364777e-11 TRUE TRUE
MSTRG.22933.5 ENSG00000178149 HEK293_OSMI2_6hA HEK293_TMG_6hB DALRD3 protein_coding   22.71113 30.33104 9.761358 3.383502 0.2082424 -1.63464 1.1798330 2.205811 0.0000000 0.3038706 0.00000000 -7.79169085 0.03465833 0.07250000 0.00000000 -0.07250000 5.364777e-11 5.364777e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000178149 E001 0.1614157 0.0328683823 0.0972535098   3 49015452 49015487 36 - 0.221 0.000 -10.821
ENSG00000178149 E002 0.6370325 0.0266179221 0.7524013381   3 49015488 49015490 3 - 0.221 0.167 -0.500
ENSG00000178149 E003 0.8094069 0.1665407007 0.9543330094   3 49015491 49015492 2 - 0.221 0.212 -0.084
ENSG00000178149 E004 17.8810893 0.0019458097 0.0207831548 0.09862592 3 49015493 49015523 31 - 0.953 1.221 0.974
ENSG00000178149 E005 20.4625280 0.0019278402 0.0079134451 0.04892191 3 49015524 49015524 1 - 0.984 1.279 1.060
ENSG00000178149 E006 48.8917006 0.2651816322 0.3114732552 0.55185522 3 49015525 49015576 52 - 1.471 1.617 0.500
ENSG00000178149 E007 60.7347440 0.3365022588 0.3151839922 0.55525520 3 49015577 49015603 27 - 1.556 1.710 0.523
ENSG00000178149 E008 108.3889940 0.5037970620 0.2616251939 0.50070615 3 49015604 49015707 104 - 1.751 1.965 0.722
ENSG00000178149 E009 8.6501584 0.3047977763 0.5262197704 0.71937090 3 49015708 49015725 18 - 1.049 0.848 -0.752
ENSG00000178149 E010 6.5513511 0.3652835315 0.3438161344 0.58146579 3 49015726 49015732 7 - 1.000 0.724 -1.063
ENSG00000178149 E011 13.9184931 0.2882848540 0.5870488782 0.76165390 3 49015733 49015803 71 - 1.243 1.027 -0.775
ENSG00000178149 E012 65.5199199 0.3414980445 0.2634733530 0.50271713 3 49015804 49015818 15 - 1.561 1.747 0.631
ENSG00000178149 E013 104.7855272 0.5159305456 0.3037688716 0.54434405 3 49015819 49015872 54 - 1.764 1.947 0.616
ENSG00000178149 E014 67.3006184 0.1566646405 0.8308567720 0.91427710 3 49015873 49015972 100 - 1.757 1.723 -0.115
ENSG00000178149 E015 148.7157861 0.0078916438 0.0673075963 0.21905249 3 49015973 49016060 88 - 1.988 2.088 0.332
ENSG00000178149 E016 82.3819989 0.0004817235 0.0342988293 0.13967843 3 49016061 49016086 26 - 1.723 1.838 0.391
ENSG00000178149 E017 49.8784011 0.0463189842 0.0174041903 0.08694569 3 49016087 49016157 71 - 1.796 1.540 -0.868
ENSG00000178149 E018 190.4076270 0.0021407151 0.9393772314 0.97192680 3 49016158 49016340 183 - 2.174 2.178 0.013
ENSG00000178149 E019 10.7689957 0.2124151873 0.1236374993 0.32147319 3 49016341 49016428 88 - 1.223 0.884 -1.240
ENSG00000178149 E020 145.1953736 0.0037066934 0.0679496904 0.22047882 3 49016429 49016511 83 - 2.118 2.045 -0.246
ENSG00000178149 E021 15.9799548 0.1693957452 0.0542398480 0.18963568 3 49016512 49016611 100 - 1.392 1.036 -1.262
ENSG00000178149 E022 123.9411256 0.0108917803 0.8094198131 0.90183177 3 49016612 49016673 62 - 1.995 1.989 -0.019
ENSG00000178149 E023 18.4333678 0.0761418908 0.0081217722 0.04988476 3 49016674 49016773 100 - 1.465 1.083 -1.340
ENSG00000178149 E024 115.6005940 0.0056669434 0.1222597687 0.31941848 3 49016774 49016788 15 - 2.020 1.946 -0.249
ENSG00000178149 E025 151.1275661 0.0003546528 0.0700018889 0.22482048 3 49016789 49016847 59 - 2.124 2.069 -0.187
ENSG00000178149 E026 5.5058860 0.0840633576 0.0091628970 0.05454538 3 49016848 49017227 380 - 1.043 0.587 -1.809
ENSG00000178149 E027 205.9926392 0.0048141077 0.1975010972 0.42649169 3 49017228 49017356 129 - 2.248 2.201 -0.158
ENSG00000178149 E028 34.2570728 0.0560954597 0.0663495129 0.21686536 3 49017357 49017433 77 - 1.628 1.390 -0.814
ENSG00000178149 E029 147.8232633 0.0039529430 0.6004299576 0.77051164 3 49017434 49017513 80 - 2.042 2.074 0.110
ENSG00000178149 E030 176.3841760 0.0004521111 0.2031455871 0.43352543 3 49017613 49017869 257 - 2.107 2.158 0.172
ENSG00000178149 E031 16.1333116 0.0276551908 0.1105283621 0.29985663 3 49017870 49018022 153 - 1.280 1.088 -0.681
ENSG00000178149 E032 78.1126851 0.0027017343 0.0248532999 0.11178202 3 49018023 49018195 173 - 1.683 1.823 0.474
ENSG00000178149 E033 33.2501372 0.0013148506 0.2103319871 0.44218982 3 49018196 49018213 18 - 1.348 1.455 0.372
ENSG00000178149 E034 48.1726631 0.0102425961 0.1796641363 0.40352495 3 49018214 49018318 105 - 1.490 1.612 0.417
ENSG00000178149 E035 14.8492998 0.0026278203 0.9303745091 0.96716509 3 49018319 49018399 81 - 1.090 1.105 0.057
ENSG00000178149 E036 56.5160590 0.0184689110 0.2506317025 0.48865729 3 49018400 49018553 154 - 1.559 1.679 0.407
ENSG00000178149 E037 34.4516954 0.0062997591 0.0005739198 0.00634495 3 49018554 49019036 483 - 1.645 1.398 -0.844
ENSG00000178149 E038 11.0972565 0.0051414782 0.8174725534 0.90663590 3 49020846 49021251 406 - 0.953 0.990 0.136
ENSG00000178149 E039 0.0000000       3 49022008 49022293 286 -