ENSG00000177853

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316045 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding protein_coding 5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 1.1996728 0.301509528 2.1133868 0.186207735 0.25988726 2.7690190 0.22009583 0.147000000 0.24930000 0.1023000 6.755969e-01 6.871421e-05 FALSE TRUE
ENST00000534948 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding retained_intron 5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 0.7690560 0.631389764 1.2325748 0.358212283 0.01394537 0.9540595 0.17059583 0.310700000 0.14600000 -0.1647000 8.864842e-01 6.871421e-05 FALSE TRUE
ENST00000539666 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding processed_transcript 5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 0.2017842 0.000000000 0.4588652 0.000000000 0.25585385 5.5511012 0.03064167 0.000000000 0.05560000 0.0556000 6.213475e-01 6.871421e-05   FALSE
ENST00000614149 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding protein_coding 5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 0.4963213 0.000000000 0.8688149 0.000000000 0.33156621 6.4574875 0.07555417 0.000000000 0.09950000 0.0995000 3.443044e-02 6.871421e-05 FALSE TRUE
ENST00000624776 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding protein_coding 5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 0.7714749 0.591981467 0.7544003 0.314447435 0.22946775 0.3446093 0.23380000 0.408900000 0.09003333 -0.3188667 7.754335e-01 6.871421e-05 FALSE TRUE
MSTRG.4421.6 ENSG00000177853 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF518A protein_coding   5.136344 1.793737 8.48291 0.3308561 0.4012258 2.23527 0.7891112 0.006378936 1.4186919 0.006378936 0.16627426 6.4467094 0.09445833 0.004566667 0.16893333 0.1643667 6.871421e-05 6.871421e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000177853 E001 0.0000000       10 96129058 96129369 312 +      
ENSG00000177853 E002 0.0000000       10 96129370 96129652 283 +      
ENSG00000177853 E003 0.0000000       10 96129653 96129714 62 +      
ENSG00000177853 E004 1.4897041 0.012625213 0.182471991 0.40723266 10 96129715 96129734 20 + 0.381 0.221 -1.080
ENSG00000177853 E005 4.7761114 0.061345600 0.446255390 0.66290431 10 96129735 96129992 258 + 0.697 0.695 -0.009
ENSG00000177853 E006 0.0000000       10 96129993 96130055 63 +      
ENSG00000177853 E007 0.4654660 0.021768165 0.371115307   10 96130056 96130071 16 + 0.167 0.000 -13.493
ENSG00000177853 E008 1.6441053 0.013696863 0.017188594 0.08613746 10 96130072 96130118 47 + 0.434 0.000 -15.364
ENSG00000177853 E009 7.0219633 0.146283609 0.110114965 0.29920086 10 96130297 96130678 382 + 0.836 0.751 -0.337
ENSG00000177853 E010 5.0719566 0.323886237 0.144108081 0.35353932 10 96130679 96130752 74 + 0.719 0.579 -0.603
ENSG00000177853 E011 1.3388170 0.706394488 0.124039440   10 96130753 96130822 70 + 0.360 0.000 -14.956
ENSG00000177853 E012 15.4253474 0.213554619 0.074284087 0.23333296 10 96132586 96132670 85 + 1.140 1.025 -0.417
ENSG00000177853 E013 1.0159857 0.915570365 0.250000783   10 96132671 96132909 239 + 0.296 0.000 -14.551
ENSG00000177853 E014 4.1941114 0.006911133 0.279216701 0.51935437 10 96133556 96133582 27 + 0.647 0.636 -0.048
ENSG00000177853 E015 16.0420553 0.175724732 0.067930289 0.22043692 10 96133583 96133648 66 + 1.151 1.073 -0.281
ENSG00000177853 E016 1.6857786 0.852228487 0.540744710 0.72954307 10 96135170 96135183 14 + 0.361 0.374 0.076
ENSG00000177853 E017 2.4365139 0.223839994 0.190533815 0.41759696 10 96135184 96135289 106 + 0.483 0.370 -0.604
ENSG00000177853 E018 8.6591510 0.237578069 0.116226290 0.30953594 10 96151416 96151566 151 + 0.912 0.807 -0.406
ENSG00000177853 E019 14.8000533 0.328660652 0.095016535 0.27298124 10 96155326 96155342 17 + 1.122 1.019 -0.375
ENSG00000177853 E020 17.4222063 0.297077255 0.030224205 0.12800552 10 96155343 96155376 34 + 1.203 0.993 -0.758
ENSG00000177853 E021 3.0277320 0.774500362 0.430072808 0.65112691 10 96155377 96155398 22 + 0.515 0.575 0.280
ENSG00000177853 E022 10.5225288 0.461407522 0.486230736 0.69141117 10 96155399 96155923 525 + 0.932 1.102 0.622
ENSG00000177853 E023 23.3060658 0.214167444 0.021313565 0.10036696 10 96155924 96156012 89 + 1.321 1.130 -0.677
ENSG00000177853 E024 9.7925115 0.047990488 0.015388974 0.07954350 10 96156013 96156047 35 + 0.972 0.803 -0.646
ENSG00000177853 E025 208.8726068 0.371335309 0.778857219 0.88405645 10 96156197 96158869 2673 + 2.199 2.302 0.345
ENSG00000177853 E026 19.5383443 0.096881725 0.321334998 0.56085504 10 96158870 96158953 84 + 1.233 1.171 -0.218
ENSG00000177853 E027 140.0955249 0.904818049 0.385530405 0.61685664 10 96158954 96160402 1449 + 1.970 2.276 1.022
ENSG00000177853 E028 228.5520325 1.105303835 0.199430655 0.42902620 10 96160403 96163761 3359 + 2.126 2.581 1.520
ENSG00000177853 E029 0.0000000       10 96197121 96197166 46 +      
ENSG00000177853 E030 0.3503582 0.390823635 0.670411350   10 96203574 96203628 55 + 0.064 0.223 2.084
ENSG00000177853 E031 6.2980101 0.005055928 0.007015489 0.04471518 10 96203920 96205288 1369 + 0.616 1.135 2.018