ENSG00000177565

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000352800 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding protein_coding 7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 1.3313936 0.09665121 4.6684895 0.06401153 0.96822598 5.455071 0.10372500 0.04590000 0.29020000 0.24430000 0.09689758 0.0077727 FALSE TRUE
ENST00000474363 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding retained_intron 7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 0.4265793 0.11286418 0.8272723 0.05265600 0.07064043 2.768633 0.06609167 0.09013333 0.04973333 -0.04040000 0.97000060 0.0077727 FALSE FALSE
ENST00000627825 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding processed_transcript 7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 0.3220918 0.00000000 0.9983647 0.00000000 0.13447617 6.655874 0.02145417 0.00000000 0.05996667 0.05996667 0.00777270 0.0077727   FALSE
ENST00000637659 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding nonsense_mediated_decay 7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 0.4366172 0.17057482 0.2135812 0.17057482 0.21358118 0.308202 0.14291250 0.06630000 0.01470000 -0.05160000 0.83224499 0.0077727 TRUE TRUE
ENST00000673974 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding protein_coding 7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 3.1249009 0.96844029 5.6582196 0.28784134 2.83029879 2.534340 0.37796250 0.51320000 0.31780000 -0.19540000 0.83904361 0.0077727 FALSE TRUE
MSTRG.24097.10 ENSG00000177565 HEK293_OSMI2_6hA HEK293_TMG_6hB TBL1XR1 protein_coding   7.729138 1.830296 16.7235 0.480049 1.135759 3.184729 0.4208512 0.00000000 1.5090752 0.00000000 0.82143263 7.247050 0.03743750 0.00000000 0.09810000 0.09810000 0.10002464 0.0077727 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000177565 E001 0.0000000       3 177019340 177019343 4 -      
ENSG00000177565 E002 0.0000000       3 177019344 177019354 11 -      
ENSG00000177565 E003 9.5700823 0.0072762172 0.008959428 0.05363309 3 177019355 177020591 1237 - 0.774 1.190 1.551
ENSG00000177565 E004 1.7575273 0.0111026273 0.237084540 0.47319106 3 177020592 177020753 162 - 0.283 0.570 1.563
ENSG00000177565 E005 1.9321145 0.1511351586 0.099899739 0.28156138 3 177020754 177020771 18 - 0.283 0.667 1.993
ENSG00000177565 E006 228.1539206 1.5905662892 0.378361193 0.61081964 3 177020772 177022475 1704 - 2.105 2.470 1.220
ENSG00000177565 E007 62.6503817 0.8984243075 0.336897551 0.57528451 3 177022476 177022925 450 - 1.569 1.855 0.970
ENSG00000177565 E008 148.1593737 1.4532565536 0.487204509 0.69204390 3 177022926 177024765 1840 - 1.949 2.169 0.739
ENSG00000177565 E009 34.5663934 0.7082289280 0.345725396 0.58332345 3 177024766 177024854 89 - 1.324 1.585 0.898
ENSG00000177565 E010 93.0084703 1.2955079291 0.557767976 0.74167728 3 177024855 177025344 490 - 1.763 1.900 0.461
ENSG00000177565 E011 48.6222978 0.2662169167 0.299144131 0.53956456 3 177025345 177025524 180 - 1.477 1.683 0.703
ENSG00000177565 E012 0.1779838 0.1048310616 0.893126544   3 177025985 177026041 57 - 0.047 0.000 -9.342
ENSG00000177565 E013 36.5540992 0.0012083663 0.763220819 0.87457793 3 177026373 177026420 48 - 1.386 1.450 0.221
ENSG00000177565 E014 43.4177469 0.0010027658 0.332808526 0.57143981 3 177026421 177026470 50 - 1.461 1.477 0.053
ENSG00000177565 E015 29.0886329 0.0089425761 0.143784763 0.35305623 3 177026471 177026474 4 - 1.299 1.239 -0.213
ENSG00000177565 E016 14.1877010 0.2453702410 0.946905693 0.97576718 3 177026475 177027830 1356 - 0.987 1.092 0.384
ENSG00000177565 E017 0.8899192 1.6671593595 1.000000000   3 177032318 177032340 23 - 0.211 0.000 -11.780
ENSG00000177565 E018 2.0213726 0.2064081989 0.615762859 0.78083446 3 177032552 177032597 46 - 0.359 0.283 -0.484
ENSG00000177565 E019 2.3276358 0.0471451320 0.452170197 0.66729437 3 177032606 177032659 54 - 0.398 0.281 -0.725
ENSG00000177565 E020 39.0105877 0.0153122642 0.620896774 0.78446109 3 177032971 177033010 40 - 1.407 1.464 0.197
ENSG00000177565 E021 58.7674468 0.0234002704 0.475695787 0.68399067 3 177033011 177033136 126 - 1.581 1.614 0.112
ENSG00000177565 E022 55.1215310 0.0088982695 0.227874013 0.46284263 3 177034198 177034325 128 - 1.560 1.560 0.002
ENSG00000177565 E023 0.0000000       3 177037637 177037842 206 -      
ENSG00000177565 E024 45.0798991 0.0008544503 0.105791125 0.29197436 3 177038098 177038172 75 - 1.486 1.449 -0.127
ENSG00000177565 E025 45.7860917 0.0915185095 0.947749488 0.97618618 3 177038313 177038428 116 - 1.479 1.514 0.117
ENSG00000177565 E026 18.6993406 0.6662235403 0.866914404 0.93430984 3 177038429 177038434 6 - 1.114 1.108 -0.022
ENSG00000177565 E027 0.0000000       3 177041072 177041181 110 -      
ENSG00000177565 E028 34.8155796 0.0068053543 0.433339845 0.65370125 3 177046129 177046189 61 - 1.374 1.388 0.048
ENSG00000177565 E029 48.9259781 0.0152430515 0.212952849 0.44522462 3 177047300 177047397 98 - 1.513 1.499 -0.048
ENSG00000177565 E030 49.1053938 0.0215924051 0.517239451 0.71314333 3 177047486 177047549 64 - 1.506 1.547 0.140
ENSG00000177565 E031 70.4757674 0.0495153652 0.362066670 0.59738696 3 177049997 177050138 142 - 1.664 1.652 -0.043
ENSG00000177565 E032 46.0345799 0.0644521500 0.158210287 0.37408810 3 177050478 177050549 72 - 1.494 1.396 -0.339
ENSG00000177565 E033 26.9885242 0.0575661085 0.049359509 0.17805680 3 177050550 177050557 8 - 1.282 1.069 -0.756
ENSG00000177565 E034 34.0500839 0.0863411187 0.132251088 0.33535824 3 177050558 177050601 44 - 1.373 1.209 -0.572
ENSG00000177565 E035 23.5221421 0.0878416093 0.209617274 0.44143592 3 177050602 177050610 9 - 1.217 1.099 -0.421
ENSG00000177565 E036 36.5811797 0.0623343201 0.212371607 0.44451651 3 177051504 177051535 32 - 1.395 1.328 -0.235
ENSG00000177565 E037 29.3762932 0.0428853501 0.220924356 0.45456573 3 177051536 177051554 19 - 1.303 1.236 -0.234
ENSG00000177565 E038 27.1733028 0.0203769069 0.138877257 0.34579532 3 177051555 177051570 16 - 1.272 1.190 -0.291
ENSG00000177565 E039 30.1226114 0.0112777375 0.021091396 0.09964937 3 177051571 177051614 44 - 1.324 1.162 -0.570
ENSG00000177565 E040 26.7466391 0.0034742830 0.458233552 0.67188096 3 177051615 177051641 27 - 1.261 1.280 0.069
ENSG00000177565 E041 34.2370306 0.0538182269 0.424947635 0.64723345 3 177051642 177051670 29 - 1.360 1.378 0.063
ENSG00000177565 E042 30.8728402 0.0620751267 0.252646522 0.49077130 3 177051671 177051686 16 - 1.323 1.273 -0.176
ENSG00000177565 E043 27.8134902 0.0495472411 0.305365251 0.54598333 3 177051687 177051700 14 - 1.277 1.236 -0.143
ENSG00000177565 E044 30.6957166 0.0553445024 0.167894613 0.38777036 3 177051701 177051726 26 - 1.322 1.238 -0.293
ENSG00000177565 E045 25.1662320 0.0733008458 0.365092133 0.60001782 3 177053773 177053791 19 - 1.235 1.210 -0.088
ENSG00000177565 E046 38.9204449 0.0472484266 0.503918774 0.70352360 3 177053792 177053877 86 - 1.410 1.432 0.078
ENSG00000177565 E047 28.0906632 0.0441672992 0.597643438 0.76873566 3 177053878 177053918 41 - 1.271 1.305 0.117
ENSG00000177565 E048 29.4518144 0.0587136830 0.275748523 0.51586534 3 177064920 177064978 59 - 1.302 1.256 -0.164
ENSG00000177565 E049 25.2388324 0.0772823758 0.225169665 0.45957529 3 177064979 177065022 44 - 1.244 1.154 -0.317
ENSG00000177565 E050 0.1426347 0.0319543620 0.871725714   3 177078632 177078778 147 - 0.047 0.000 -9.335
ENSG00000177565 E051 0.0000000       3 177079454 177079826 373 -      
ENSG00000177565 E052 1.7942478 0.2276211773 0.721240235 0.84890930 3 177079827 177079886 60 - 0.334 0.281 -0.347
ENSG00000177565 E053 1.9133495 0.1965570208 0.428321372 0.64969739 3 177079887 177079945 59 - 0.311 0.564 1.349
ENSG00000177565 E054 0.0000000       3 177086965 177087041 77 -      
ENSG00000177565 E055 0.4632531 0.0327552690 1.000000000   3 177091151 177091180 30 - 0.129 0.000 -10.920
ENSG00000177565 E056 14.1565400 0.0785372019 0.810737183 0.90269102 3 177098466 177098470 5 - 0.994 1.039 0.163
ENSG00000177565 E057 16.1849973 0.0732678578 0.812086711 0.90345913 3 177098471 177098486 16 - 1.047 1.102 0.200
ENSG00000177565 E058 16.9371040 0.0715675253 0.429117356 0.65034550 3 177098487 177098541 55 - 1.077 1.035 -0.150
ENSG00000177565 E059 0.0000000       3 177099405 177099447 43 -      
ENSG00000177565 E060 0.1308682 0.0326491905 0.055875214   3 177110809 177110887 79 - 0.000 0.279 15.251
ENSG00000177565 E061 2.0730862 0.1494649065 0.414916463 0.63975847 3 177131363 177131376 14 - 0.310 0.580 1.425
ENSG00000177565 E062 2.0730862 0.1494649065 0.414916463 0.63975847 3 177131377 177131377 1 - 0.310 0.580 1.425
ENSG00000177565 E063 2.5551204 0.1172885254 0.601320649 0.77102477 3 177131378 177131449 72 - 0.378 0.578 1.003
ENSG00000177565 E064 0.0000000       3 177136217 177136245 29 -      
ENSG00000177565 E065 1.4273215 0.0131725257 0.230463299 0.46564549 3 177160871 177160988 118 - 0.308 0.000 -12.506
ENSG00000177565 E066 0.0000000       3 177163978 177164001 24 -      
ENSG00000177565 E067 0.0000000       3 177171390 177171417 28 -      
ENSG00000177565 E068 0.0000000       3 177194064 177194126 63 -      
ENSG00000177565 E069 0.0000000       3 177195588 177195664 77 -      
ENSG00000177565 E070 1.7030372 0.0108341337 0.662468137 0.81143579 3 177196340 177196484 145 - 0.332 0.280 -0.346
ENSG00000177565 E071 18.5252936 0.0879993489 0.193799746 0.42186867 3 177197121 177197482 362 - 1.122 0.994 -0.465
ENSG00000177565 E072 0.0000000       3 177201739 177201817 79 -      
ENSG00000177565 E073 0.0000000       3 177227868 177228000 133 -