ENSG00000177302

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000321105 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding protein_coding 23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 11.201543 15.079422 7.700565 1.2924410 0.3097801 -0.9686291 0.48095000 0.51926667 0.37083333 -0.1484333333 0.01186879 0.01186879 FALSE TRUE
ENST00000469739 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding retained_intron 23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 1.193456 1.421710 1.018713 0.3324927 0.1408622 -0.4768987 0.05147083 0.04926667 0.04893333 -0.0003333333 1.00000000 0.01186879 FALSE TRUE
ENST00000542570 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding protein_coding 23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 1.952313 2.480166 3.734398 1.3448514 0.5631828 0.5884920 0.08650000 0.08313333 0.18110000 0.0979666667 0.75356739 0.01186879 FALSE TRUE
ENST00000583804 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding retained_intron 23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 1.158299 1.113966 1.278372 0.3808761 0.3602398 0.1969511 0.05080833 0.04003333 0.06066667 0.0206333333 0.75540947 0.01186879 FALSE FALSE
ENST00000584582 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding nonsense_mediated_decay 23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 1.921227 3.723635 1.148984 0.9783002 0.8692232 -1.6877197 0.07953750 0.12653333 0.05303333 -0.0735000000 0.63208999 0.01186879 FALSE TRUE
MSTRG.13793.9 ENSG00000177302 HEK293_OSMI2_6hA HEK293_TMG_6hB TOP3A protein_coding   23.06479 28.98194 20.77264 1.817894 0.6068258 -0.4802729 1.341870 1.632097 1.911818 0.8092152 0.2499986 0.2269327 0.05945000 0.05916667 0.09166667 0.0325000000 0.67746187 0.01186879 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000177302 E001 7.125623 0.1323675585 3.504675e-02 1.417091e-01 17 18271404 18271427 24 - 0.502 0.999 2.048
ENSG00000177302 E002 31.722734 0.3168125872 8.789909e-02 2.598119e-01 17 18271428 18271571 144 - 1.201 1.595 1.366
ENSG00000177302 E003 33.582410 0.3156806537 6.274928e-02 2.089301e-01 17 18271572 18271614 43 - 1.200 1.625 1.470
ENSG00000177302 E004 39.059370 0.4096897815 1.433815e-01 3.525066e-01 17 18271615 18271673 59 - 1.334 1.673 1.163
ENSG00000177302 E005 355.314604 0.0055325146 6.287667e-04 6.829052e-03 17 18271674 18272837 1164 - 2.426 2.576 0.499
ENSG00000177302 E006 185.452119 0.0002622114 2.029185e-08 8.883790e-07 17 18272838 18273243 406 - 2.125 2.297 0.573
ENSG00000177302 E007 123.731212 0.0003374457 8.560852e-04 8.741685e-03 17 18273244 18273336 93 - 1.984 2.109 0.420
ENSG00000177302 E008 259.546942 0.0016372855 1.225168e-02 6.744521e-02 17 18273337 18273920 584 - 2.332 2.418 0.288
ENSG00000177302 E009 35.655986 0.0010272962 2.959072e-01 5.364078e-01 17 18273921 18273966 46 - 1.488 1.562 0.255
ENSG00000177302 E010 96.389889 0.0004812468 4.889783e-02 1.770042e-01 17 18273967 18274227 261 - 1.904 1.990 0.290
ENSG00000177302 E011 380.874622 0.0001804814 9.338472e-02 2.700283e-01 17 18274228 18274723 496 - 2.531 2.572 0.139
ENSG00000177302 E012 145.692347 0.0003271172 6.597356e-01 8.098294e-01 17 18274724 18274794 71 - 2.128 2.151 0.076
ENSG00000177302 E013 96.588990 0.0003931186 7.562389e-01 8.703654e-01 17 18274795 18274803 9 - 1.968 1.965 -0.010
ENSG00000177302 E014 245.845895 0.0002873139 1.750797e-01 3.972605e-01 17 18274804 18274980 177 - 2.338 2.381 0.142
ENSG00000177302 E015 490.853684 0.0013269748 5.618382e-04 6.237370e-03 17 18277675 18278357 683 - 2.607 2.699 0.307
ENSG00000177302 E016 2.099183 0.5677383873 9.086753e-01 9.564424e-01 17 18280175 18280535 361 - 0.430 0.504 0.374
ENSG00000177302 E017 145.647768 0.0003854422 3.414889e-01 5.793771e-01 17 18280536 18280658 123 - 2.117 2.156 0.131
ENSG00000177302 E018 162.448750 0.0009052513 3.367884e-01 5.752055e-01 17 18282698 18282790 93 - 2.203 2.183 -0.068
ENSG00000177302 E019 151.813956 0.0051589091 8.082219e-01 9.011668e-01 17 18282791 18282841 51 - 2.157 2.161 0.013
ENSG00000177302 E020 253.329539 0.0019808452 4.594445e-01 6.727404e-01 17 18285142 18285307 166 - 2.386 2.376 -0.036
ENSG00000177302 E021 120.293871 0.0004006455 7.662655e-01 8.763740e-01 17 18285407 18285427 21 - 2.060 2.058 -0.004
ENSG00000177302 E022 184.091839 0.0008813952 6.504242e-02 2.139930e-01 17 18285428 18285520 93 - 2.273 2.228 -0.152
ENSG00000177302 E023 2.311649 0.0114484445 9.426260e-01 9.735956e-01 17 18290540 18290556 17 - 0.503 0.497 -0.029
ENSG00000177302 E024 186.585274 0.0002820362 3.571004e-02 1.434611e-01 17 18290557 18290686 130 - 2.279 2.230 -0.162
ENSG00000177302 E025 213.629729 0.0002889880 1.354842e-02 7.254946e-02 17 18290842 18291027 186 - 2.342 2.287 -0.181
ENSG00000177302 E026 208.002220 0.0002712949 5.206913e-02 1.845596e-01 17 18292645 18292852 208 - 2.321 2.280 -0.138
ENSG00000177302 E027 146.545856 0.0006894436 3.198423e-03 2.459768e-02 17 18294703 18294785 83 - 2.196 2.112 -0.283
ENSG00000177302 E028 141.199989 0.0031481679 6.991471e-01 8.350575e-01 17 18299559 18299633 75 - 2.131 2.126 -0.015
ENSG00000177302 E029 139.234519 0.0018048997 5.056646e-01 7.047197e-01 17 18301885 18301985 101 - 2.133 2.119 -0.048
ENSG00000177302 E030 164.147482 0.0002585351 9.336723e-01 9.689631e-01 17 18302264 18302434 171 - 2.186 2.198 0.038
ENSG00000177302 E031 88.259546 0.0004719209 2.302646e-01 4.654320e-01 17 18302580 18302603 24 - 1.951 1.912 -0.129
ENSG00000177302 E032 145.340049 0.0003150858 1.084112e-01 2.964115e-01 17 18302604 18302685 82 - 2.167 2.127 -0.136
ENSG00000177302 E033 101.644908 0.0003768502 5.201154e-02 1.844307e-01 17 18302686 18302723 38 - 2.027 1.965 -0.208
ENSG00000177302 E034 17.140562 0.0759632517 1.309406e-01 3.332843e-01 17 18302724 18303090 367 - 1.359 1.159 -0.704
ENSG00000177302 E035 164.475251 0.0012409414 5.152676e-04 5.816170e-03 17 18305112 18305220 109 - 2.261 2.158 -0.341
ENSG00000177302 E036 3.985008 0.0318932342 1.342998e-02 7.211306e-02 17 18306550 18306587 38 - 0.881 0.498 -1.621
ENSG00000177302 E037 14.574854 0.0616344672 4.956872e-03 3.440347e-02 17 18306588 18306890 303 - 1.384 1.000 -1.369
ENSG00000177302 E038 113.298777 0.0003901496 3.889406e-04 4.624499e-03 17 18306891 18306933 43 - 2.105 1.992 -0.379
ENSG00000177302 E039 98.048347 0.0005626246 6.922230e-04 7.376719e-03 17 18306934 18306962 29 - 2.046 1.928 -0.395
ENSG00000177302 E040 69.648038 0.0017995546 2.646250e-02 1.166629e-01 17 18306963 18306966 4 - 1.885 1.789 -0.322
ENSG00000177302 E041 7.726854 0.0630202889 2.298292e-02 1.058965e-01 17 18306967 18307159 193 - 1.108 0.766 -1.291
ENSG00000177302 E042 3.269762 0.0484603386 6.592481e-02 2.160116e-01 17 18307473 18307525 53 - 0.796 0.494 -1.308
ENSG00000177302 E043 1.255544 0.0139239698 1.165501e-01   17 18307526 18307531 6 - 0.503 0.234 -1.617
ENSG00000177302 E044 2.200024 0.0105635320 2.802826e-02 1.213348e-01 17 18307532 18307570 39 - 0.693 0.340 -1.728
ENSG00000177302 E045 7.784741 0.0417576258 2.405506e-02 1.092507e-01 17 18308313 18308350 38 - 1.093 0.783 -1.169
ENSG00000177302 E046 100.790874 0.0010045906 1.215811e-03 1.155157e-02 17 18308351 18308412 62 - 2.052 1.937 -0.386
ENSG00000177302 E047 57.613693 0.0115157906 2.747898e-02 1.197383e-01 17 18308413 18308424 12 - 1.830 1.685 -0.488
ENSG00000177302 E048 3.328314 0.2141917848 3.506540e-01 5.878145e-01 17 18308682 18308881 200 - 0.736 0.533 -0.880
ENSG00000177302 E049 98.967056 0.0063125141 7.501492e-02 2.348577e-01 17 18308882 18308941 60 - 2.029 1.945 -0.280
ENSG00000177302 E050 146.570143 0.0031594856 2.767489e-01 5.167377e-01 17 18314599 18315007 409 - 2.170 2.137 -0.109