ENSG00000177302

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-6 / 6
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000321105	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding	protein_coding	23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	11.201543	15.079422	7.700565	1.2924410	0.3097801	-0.9686291	0.48095000	0.51926667	0.37083333	-0.1484333333	0.01186879	0.01186879	FALSE	TRUE
ENST00000469739	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding	retained_intron	23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	1.193456	1.421710	1.018713	0.3324927	0.1408622	-0.4768987	0.05147083	0.04926667	0.04893333	-0.0003333333	1.00000000	0.01186879	FALSE	TRUE
ENST00000542570	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding	protein_coding	23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	1.952313	2.480166	3.734398	1.3448514	0.5631828	0.5884920	0.08650000	0.08313333	0.18110000	0.0979666667	0.75356739	0.01186879	FALSE	TRUE
ENST00000583804	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding	retained_intron	23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	1.158299	1.113966	1.278372	0.3808761	0.3602398	0.1969511	0.05080833	0.04003333	0.06066667	0.0206333333	0.75540947	0.01186879	FALSE	FALSE
ENST00000584582	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding	nonsense_mediated_decay	23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	1.921227	3.723635	1.148984	0.9783002	0.8692232	-1.6877197	0.07953750	0.12653333	0.05303333	-0.0735000000	0.63208999	0.01186879	FALSE	TRUE
MSTRG.13793.9	ENSG00000177302	HEK293_OSMI2_6hA	HEK293_TMG_6hB	TOP3A	protein_coding		23.06479	28.98194	20.77264	1.817894	0.6068258	-0.4802729	1.341870	1.632097	1.911818	0.8092152	0.2499986	0.2269327	0.05945000	0.05916667	0.09166667	0.0325000000	0.67746187	0.01186879	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

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featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_6hB
HEK293_OSMI2_6hA
log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_6hB	HEK293_OSMI2_6hA	log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB

ENSG00000177302	E001	7.125623	0.1323675585	3.504675e-02	1.417091e-01	17	18271404	18271427	24	-	0.502	0.999	2.048
ENSG00000177302	E002	31.722734	0.3168125872	8.789909e-02	2.598119e-01	17	18271428	18271571	144	-	1.201	1.595	1.366
ENSG00000177302	E003	33.582410	0.3156806537	6.274928e-02	2.089301e-01	17	18271572	18271614	43	-	1.200	1.625	1.470
ENSG00000177302	E004	39.059370	0.4096897815	1.433815e-01	3.525066e-01	17	18271615	18271673	59	-	1.334	1.673	1.163
ENSG00000177302	E005	355.314604	0.0055325146	6.287667e-04	6.829052e-03	17	18271674	18272837	1164	-	2.426	2.576	0.499
ENSG00000177302	E006	185.452119	0.0002622114	2.029185e-08	8.883790e-07	17	18272838	18273243	406	-	2.125	2.297	0.573
ENSG00000177302	E007	123.731212	0.0003374457	8.560852e-04	8.741685e-03	17	18273244	18273336	93	-	1.984	2.109	0.420
ENSG00000177302	E008	259.546942	0.0016372855	1.225168e-02	6.744521e-02	17	18273337	18273920	584	-	2.332	2.418	0.288
ENSG00000177302	E009	35.655986	0.0010272962	2.959072e-01	5.364078e-01	17	18273921	18273966	46	-	1.488	1.562	0.255
ENSG00000177302	E010	96.389889	0.0004812468	4.889783e-02	1.770042e-01	17	18273967	18274227	261	-	1.904	1.990	0.290
ENSG00000177302	E011	380.874622	0.0001804814	9.338472e-02	2.700283e-01	17	18274228	18274723	496	-	2.531	2.572	0.139
ENSG00000177302	E012	145.692347	0.0003271172	6.597356e-01	8.098294e-01	17	18274724	18274794	71	-	2.128	2.151	0.076
ENSG00000177302	E013	96.588990	0.0003931186	7.562389e-01	8.703654e-01	17	18274795	18274803	9	-	1.968	1.965	-0.010
ENSG00000177302	E014	245.845895	0.0002873139	1.750797e-01	3.972605e-01	17	18274804	18274980	177	-	2.338	2.381	0.142
ENSG00000177302	E015	490.853684	0.0013269748	5.618382e-04	6.237370e-03	17	18277675	18278357	683	-	2.607	2.699	0.307
ENSG00000177302	E016	2.099183	0.5677383873	9.086753e-01	9.564424e-01	17	18280175	18280535	361	-	0.430	0.504	0.374
ENSG00000177302	E017	145.647768	0.0003854422	3.414889e-01	5.793771e-01	17	18280536	18280658	123	-	2.117	2.156	0.131
ENSG00000177302	E018	162.448750	0.0009052513	3.367884e-01	5.752055e-01	17	18282698	18282790	93	-	2.203	2.183	-0.068
ENSG00000177302	E019	151.813956	0.0051589091	8.082219e-01	9.011668e-01	17	18282791	18282841	51	-	2.157	2.161	0.013
ENSG00000177302	E020	253.329539	0.0019808452	4.594445e-01	6.727404e-01	17	18285142	18285307	166	-	2.386	2.376	-0.036
ENSG00000177302	E021	120.293871	0.0004006455	7.662655e-01	8.763740e-01	17	18285407	18285427	21	-	2.060	2.058	-0.004
ENSG00000177302	E022	184.091839	0.0008813952	6.504242e-02	2.139930e-01	17	18285428	18285520	93	-	2.273	2.228	-0.152
ENSG00000177302	E023	2.311649	0.0114484445	9.426260e-01	9.735956e-01	17	18290540	18290556	17	-	0.503	0.497	-0.029
ENSG00000177302	E024	186.585274	0.0002820362	3.571004e-02	1.434611e-01	17	18290557	18290686	130	-	2.279	2.230	-0.162
ENSG00000177302	E025	213.629729	0.0002889880	1.354842e-02	7.254946e-02	17	18290842	18291027	186	-	2.342	2.287	-0.181
ENSG00000177302	E026	208.002220	0.0002712949	5.206913e-02	1.845596e-01	17	18292645	18292852	208	-	2.321	2.280	-0.138
ENSG00000177302	E027	146.545856	0.0006894436	3.198423e-03	2.459768e-02	17	18294703	18294785	83	-	2.196	2.112	-0.283
ENSG00000177302	E028	141.199989	0.0031481679	6.991471e-01	8.350575e-01	17	18299559	18299633	75	-	2.131	2.126	-0.015
ENSG00000177302	E029	139.234519	0.0018048997	5.056646e-01	7.047197e-01	17	18301885	18301985	101	-	2.133	2.119	-0.048
ENSG00000177302	E030	164.147482	0.0002585351	9.336723e-01	9.689631e-01	17	18302264	18302434	171	-	2.186	2.198	0.038
ENSG00000177302	E031	88.259546	0.0004719209	2.302646e-01	4.654320e-01	17	18302580	18302603	24	-	1.951	1.912	-0.129
ENSG00000177302	E032	145.340049	0.0003150858	1.084112e-01	2.964115e-01	17	18302604	18302685	82	-	2.167	2.127	-0.136
ENSG00000177302	E033	101.644908	0.0003768502	5.201154e-02	1.844307e-01	17	18302686	18302723	38	-	2.027	1.965	-0.208
ENSG00000177302	E034	17.140562	0.0759632517	1.309406e-01	3.332843e-01	17	18302724	18303090	367	-	1.359	1.159	-0.704
ENSG00000177302	E035	164.475251	0.0012409414	5.152676e-04	5.816170e-03	17	18305112	18305220	109	-	2.261	2.158	-0.341
ENSG00000177302	E036	3.985008	0.0318932342	1.342998e-02	7.211306e-02	17	18306550	18306587	38	-	0.881	0.498	-1.621
ENSG00000177302	E037	14.574854	0.0616344672	4.956872e-03	3.440347e-02	17	18306588	18306890	303	-	1.384	1.000	-1.369
ENSG00000177302	E038	113.298777	0.0003901496	3.889406e-04	4.624499e-03	17	18306891	18306933	43	-	2.105	1.992	-0.379
ENSG00000177302	E039	98.048347	0.0005626246	6.922230e-04	7.376719e-03	17	18306934	18306962	29	-	2.046	1.928	-0.395
ENSG00000177302	E040	69.648038	0.0017995546	2.646250e-02	1.166629e-01	17	18306963	18306966	4	-	1.885	1.789	-0.322
ENSG00000177302	E041	7.726854	0.0630202889	2.298292e-02	1.058965e-01	17	18306967	18307159	193	-	1.108	0.766	-1.291
ENSG00000177302	E042	3.269762	0.0484603386	6.592481e-02	2.160116e-01	17	18307473	18307525	53	-	0.796	0.494	-1.308
ENSG00000177302	E043	1.255544	0.0139239698	1.165501e-01		17	18307526	18307531	6	-	0.503	0.234	-1.617
ENSG00000177302	E044	2.200024	0.0105635320	2.802826e-02	1.213348e-01	17	18307532	18307570	39	-	0.693	0.340	-1.728
ENSG00000177302	E045	7.784741	0.0417576258	2.405506e-02	1.092507e-01	17	18308313	18308350	38	-	1.093	0.783	-1.169
ENSG00000177302	E046	100.790874	0.0010045906	1.215811e-03	1.155157e-02	17	18308351	18308412	62	-	2.052	1.937	-0.386
ENSG00000177302	E047	57.613693	0.0115157906	2.747898e-02	1.197383e-01	17	18308413	18308424	12	-	1.830	1.685	-0.488
ENSG00000177302	E048	3.328314	0.2141917848	3.506540e-01	5.878145e-01	17	18308682	18308881	200	-	0.736	0.533	-0.880
ENSG00000177302	E049	98.967056	0.0063125141	7.501492e-02	2.348577e-01	17	18308882	18308941	60	-	2.029	1.945	-0.280
ENSG00000177302	E050	146.570143	0.0031594856	2.767489e-01	5.167377e-01	17	18314599	18315007	409	-	2.170	2.137	-0.109

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000177302

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3