ENSG00000177150

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402563 ENSG00000177150 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM210A protein_coding protein_coding 6.63519 2.469526 10.4959 0.1652323 0.1395329 2.083063 2.3354680 1.26890128 3.385990 0.22134063 0.09927941 1.4089272 0.4458625 0.51406667 0.3225333 -0.19153333 0.3589063323 0.0003216381 FALSE TRUE
ENST00000585785 ENSG00000177150 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM210A protein_coding processed_transcript 6.63519 2.469526 10.4959 0.1652323 0.1395329 2.083063 0.6235057 0.08336116 1.484802 0.08336116 0.22488051 4.0009885 0.0809250 0.02986667 0.1416000 0.11173333 0.2903145619 0.0003216381   FALSE
ENST00000588475 ENSG00000177150 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM210A protein_coding processed_transcript 6.63519 2.469526 10.4959 0.1652323 0.1395329 2.083063 0.9786459 0.66723255 1.190178 0.10511317 0.09596828 0.8255254 0.1439250 0.26706667 0.1134667 -0.15360000 0.0121484792 0.0003216381 FALSE TRUE
ENST00000589346 ENSG00000177150 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM210A protein_coding protein_coding 6.63519 2.469526 10.4959 0.1652323 0.1395329 2.083063 0.8964493 0.38032615 1.955073 0.21243234 0.42006046 2.3318306 0.1454500 0.15913333 0.1853000 0.02616667 0.9050481935 0.0003216381 FALSE FALSE
ENST00000592976 ENSG00000177150 HEK293_OSMI2_6hA HEK293_TMG_6hB FAM210A protein_coding protein_coding 6.63519 2.469526 10.4959 0.1652323 0.1395329 2.083063 1.2521970 0.00000000 2.001140 0.00000000 0.59463227 7.6518699 0.1142042 0.00000000 0.1919333 0.19193333 0.0003216381 0.0003216381 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000177150 E001 0.0000000       18 13663347 13663350 4 -      
ENSG00000177150 E002 132.6933315 0.001637994 0.001193447 0.01138239 18 13663351 13665882 2532 - 2.047 2.150 0.343
ENSG00000177150 E003 33.5264422 0.004956663 0.763654431 0.87485639 18 13665883 13666002 120 - 1.480 1.499 0.065
ENSG00000177150 E004 54.7938508 0.000986016 0.467650603 0.67846797 18 13666003 13666230 228 - 1.709 1.674 -0.119
ENSG00000177150 E005 58.6189207 0.001330739 0.898723344 0.95122402 18 13666231 13666493 263 - 1.728 1.737 0.028
ENSG00000177150 E006 70.2392900 0.005783917 0.089021215 0.26193903 18 13666494 13666713 220 - 1.833 1.739 -0.320
ENSG00000177150 E007 5.9900700 0.005555994 0.671375476 0.81718894 18 13670871 13670968 98 - 0.817 0.758 -0.233
ENSG00000177150 E008 30.4133301 0.001501497 0.112188753 0.30275756 18 13671862 13671911 50 - 1.482 1.372 -0.381
ENSG00000177150 E009 30.0314307 0.001850559 0.072142859 0.22911448 18 13671912 13671973 62 - 1.480 1.352 -0.441
ENSG00000177150 E010 80.2731261 0.004717636 0.907715066 0.95600419 18 13681605 13682105 501 - 1.866 1.863 -0.012
ENSG00000177150 E011 1.5593573 0.114005464 0.251698034 0.48973551 18 13687743 13687882 140 - 0.441 0.185 -1.732
ENSG00000177150 E012 0.1723744 0.035675580 0.176177127   18 13697547 13697674 128 - 0.000 0.183 10.173
ENSG00000177150 E013 18.1572248 0.002622128 0.395116267 0.62447416 18 13726329 13726663 335 - 1.222 1.298 0.267