ENSG00000177058

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000318672 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding protein_coding 9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 4.6322436 1.61875066 6.2186175 0.15953308 0.50843286 1.935146 0.49999583 0.50643333 0.45206667 -0.05436667 8.206946e-01 1.508283e-10 FALSE TRUE
ENST00000396865 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding protein_coding 9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 0.9039862 0.04756305 2.8616964 0.02392073 0.05461795 5.640616 0.07605833 0.01540000 0.20933333 0.19393333 6.201584e-08 1.508283e-10 FALSE TRUE
ENST00000504880 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding processed_transcript 9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 0.5802393 0.76122943 0.2606105 0.02113083 0.05387676 -1.510942 0.11100000 0.24086667 0.01930000 -0.22156667 1.508283e-10 1.508283e-10 FALSE FALSE
MSTRG.26200.10 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding   9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 0.4566623 0.05610920 1.0613498 0.05610920 0.30059512 4.018435 0.03722917 0.01663333 0.07776667 0.06113333 3.375278e-01 1.508283e-10 FALSE TRUE
MSTRG.26200.11 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding   9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 0.8567312 0.00000000 1.1811752 0.00000000 0.35504769 6.896242 0.06851250 0.00000000 0.08490000 0.08490000 1.320563e-03 1.508283e-10 FALSE TRUE
MSTRG.26200.3 ENSG00000177058 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC38A9 protein_coding   9.295854 3.183258 13.72486 0.1648841 0.4958528 2.104741 0.7643805 0.26124334 0.9197177 0.05069648 0.11780042 1.777205 0.08408750 0.08106667 0.06763333 -0.01343333 8.720499e-01 1.508283e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000177058 E001 0.8274031 0.0170421492 8.491568e-01   5 55625845 55625846 2 - 0.198 0.236 0.323
ENSG00000177058 E002 0.8274031 0.0170421492 8.491568e-01   5 55625847 55625847 1 - 0.198 0.236 0.323
ENSG00000177058 E003 1.3695368 0.0135714446 5.595158e-01   5 55625848 55625857 10 - 0.271 0.388 0.739
ENSG00000177058 E004 40.5962045 0.0009522285 2.080425e-01 4.394712e-01 5 55625858 55626072 215 - 1.479 1.569 0.307
ENSG00000177058 E005 60.0966456 0.0007051489 5.877649e-02 2.000173e-01 5 55626073 55626252 180 - 1.643 1.752 0.369
ENSG00000177058 E006 29.6476659 0.0013742647 5.747337e-02 1.971154e-01 5 55626253 55626253 1 - 1.335 1.486 0.520
ENSG00000177058 E007 31.3918494 0.0011926691 1.789008e-01 4.024836e-01 5 55626254 55626255 2 - 1.369 1.475 0.368
ENSG00000177058 E008 56.6369256 0.0006995647 2.866638e-01 5.273706e-01 5 55626256 55626410 155 - 1.627 1.693 0.223
ENSG00000177058 E009 49.1007539 0.0010805253 5.749878e-01 7.536577e-01 5 55626411 55626559 149 - 1.586 1.552 -0.116
ENSG00000177058 E010 48.7833892 0.0014117514 7.459919e-01 8.643531e-01 5 55626560 55626659 100 - 1.579 1.560 -0.064
ENSG00000177058 E011 46.7786151 0.0011055394 6.504683e-01 8.038224e-01 5 55627891 55627980 90 - 1.561 1.534 -0.093
ENSG00000177058 E012 0.8323924 0.0172671820 8.504612e-01   5 55633396 55633694 299 - 0.198 0.236 0.320
ENSG00000177058 E013 1.3253852 0.0395579589 5.633626e-01   5 55633695 55633753 59 - 0.271 0.388 0.737
ENSG00000177058 E014 46.0975285 0.0011089060 1.255508e-01 3.247262e-01 5 55633754 55633808 55 - 1.530 1.632 0.347
ENSG00000177058 E015 55.9848363 0.0008464915 1.047763e-01 2.902492e-01 5 55633809 55633902 94 - 1.614 1.712 0.332
ENSG00000177058 E016 5.1921239 0.0071887849 2.112175e-01 4.432338e-01 5 55633903 55635543 1641 - 0.726 0.500 -1.000
ENSG00000177058 E017 56.2128932 0.0008047480 1.567231e-01 3.718504e-01 5 55635544 55635657 114 - 1.620 1.706 0.291
ENSG00000177058 E018 47.4653668 0.0013691170 4.039538e-01 6.314784e-01 5 55645789 55645895 107 - 1.577 1.524 -0.183
ENSG00000177058 E019 27.0159270 0.0016743378 5.174933e-01 7.133004e-01 5 55649207 55649209 3 - 1.323 1.381 0.201
ENSG00000177058 E020 41.7895764 0.0009661485 9.558062e-01 9.797975e-01 5 55649210 55649314 105 - 1.515 1.515 -0.002
ENSG00000177058 E021 50.0188756 0.0008698188 7.818728e-03 4.847754e-02 5 55652529 55652723 195 - 1.616 1.431 -0.634
ENSG00000177058 E022 26.4551253 0.0014965488 1.804321e-03 1.573216e-02 5 55656715 55656720 6 - 1.363 1.045 -1.128
ENSG00000177058 E023 30.2400647 0.0015380144 7.983310e-03 4.922660e-02 5 55656721 55656744 24 - 1.412 1.167 -0.856
ENSG00000177058 E024 29.2132538 0.0014241718 1.681785e-03 1.489392e-02 5 55656745 55656774 30 - 1.402 1.098 -1.071
ENSG00000177058 E025 0.0000000       5 55657970 55658038 69 -      
ENSG00000177058 E026 0.3150090 0.0292790571 2.428033e-01   5 55664560 55664692 133 - 0.058 0.236 2.324
ENSG00000177058 E027 48.2693564 0.0008649984 1.355914e-02 7.259998e-02 5 55664693 55664863 171 - 1.594 1.419 -0.599
ENSG00000177058 E028 0.1723744 0.0373703959 7.918720e-02   5 55664864 55665132 269 - 0.000 0.236 13.237
ENSG00000177058 E029 0.1779838 0.0351862952 1.000000e+00   5 55669121 55669227 107 - 0.059 0.000 -8.630
ENSG00000177058 E030 31.5544005 0.0011201821 4.616232e-02 1.704185e-01 5 55669228 55669258 31 - 1.417 1.245 -0.598
ENSG00000177058 E031 42.2605432 0.0012645069 1.003989e-01 2.824960e-01 5 55669259 55669321 63 - 1.537 1.419 -0.408
ENSG00000177058 E032 41.2378796 0.0107666859 7.166057e-01 8.459950e-01 5 55669557 55669595 39 - 1.513 1.492 -0.073
ENSG00000177058 E033 34.2566016 0.0013213227 2.324172e-01 4.679841e-01 5 55669596 55669620 25 - 1.447 1.354 -0.320
ENSG00000177058 E034 0.1426347 0.0316015583 1.000000e+00   5 55669621 55669665 45 - 0.058 0.000 -8.627
ENSG00000177058 E035 43.7892039 0.0008773226 9.543209e-01 9.790534e-01 5 55669758 55669828 71 - 1.534 1.533 -0.001
ENSG00000177058 E036 23.6434374 0.0018471048 5.327788e-02 1.873999e-01 5 55669829 55669835 7 - 1.238 1.407 0.588
ENSG00000177058 E037 37.1331197 0.0010064149 6.188130e-02 2.070631e-01 5 55669836 55669879 44 - 1.435 1.569 0.458
ENSG00000177058 E038 55.2088115 0.0007234552 2.572278e-01 4.959801e-01 5 55672563 55672695 133 - 1.616 1.686 0.241
ENSG00000177058 E039 0.1614157 0.0344519252 1.000000e+00   5 55672696 55672822 127 - 0.059 0.000 -8.629
ENSG00000177058 E040 0.5421338 0.0224370377 4.594475e-01   5 55673304 55673448 145 - 0.110 0.236 1.322
ENSG00000177058 E041 0.0000000       5 55675247 55675331 85 -      
ENSG00000177058 E042 0.0000000       5 55691189 55691292 104 -      
ENSG00000177058 E043 0.1779838 0.0351862952 1.000000e+00   5 55692590 55692870 281 - 0.059 0.000 -8.630
ENSG00000177058 E044 0.4952057 0.3449453288 4.744518e-01   5 55692871 55693429 559 - 0.110 0.237 1.328
ENSG00000177058 E045 0.0000000       5 55694083 55694204 122 -      
ENSG00000177058 E046 6.8124228 0.0384095986 2.525620e-13 2.909826e-11 5 55695992 55697212 1221 - 0.334 1.388 4.340
ENSG00000177058 E047 36.9302596 0.0055567362 4.913184e-01 6.948361e-01 5 55697846 55697878 33 - 1.446 1.505 0.204
ENSG00000177058 E048 52.7520948 0.0011257751 8.920683e-01 9.476235e-01 5 55697879 55697958 80 - 1.607 1.602 -0.017
ENSG00000177058 E049 39.1470382 0.0012549152 9.146246e-02 2.663945e-01 5 55697959 55697992 34 - 1.498 1.369 -0.445
ENSG00000177058 E050 0.3206185 0.0274424043 1.000000e+00   5 55697993 55697994 2 - 0.110 0.000 -9.628
ENSG00000177058 E051 11.5535731 0.0304071836 1.199752e-01 3.158061e-01 5 55702739 55702891 153 - 1.022 0.779 -0.927
ENSG00000177058 E052 2.6685105 0.0163750156 9.325852e-01 9.684554e-01 5 55702892 55702894 3 - 0.480 0.500 0.095
ENSG00000177058 E053 0.8158242 0.0172671820 8.502870e-01   5 55704043 55704140 98 - 0.198 0.236 0.321
ENSG00000177058 E054 0.0000000       5 55704275 55704321 47 -      
ENSG00000177058 E055 16.9012230 0.0098551384 6.308857e-01 7.909616e-01 5 55704322 55704434 113 - 1.128 1.187 0.210
ENSG00000177058 E056 1.4687599 0.1122370175 1.587825e-01 3.749290e-01 5 55711352 55711451 100 - 0.270 0.581 1.700
ENSG00000177058 E057 41.0220367 0.0012630103 1.139877e-01 3.057659e-01 5 55711452 55711499 48 - 1.523 1.407 -0.399
ENSG00000177058 E058 36.9818810 0.0011295574 5.634618e-01 7.457158e-01 5 55712217 55712726 510 - 1.471 1.430 -0.139
ENSG00000177058 E059 0.0000000       5 55773081 55773194 114 -