ENSG00000176783

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000319449 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding protein_coding 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 10.638021 10.537291 7.639179 2.4650642 0.6030812 -0.46349584 0.28819167 0.27836667 0.18283333 -0.09553333 0.478080667 0.002688731 FALSE TRUE
ENST00000393438 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding protein_coding 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 6.121014 4.729526 10.181486 1.0599339 1.0681606 1.10454974 0.16613750 0.12563333 0.24310000 0.11746667 0.079640463 0.002688731 FALSE TRUE
ENST00000437570 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding protein_coding 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 6.723541 7.611074 7.723431 1.3102785 1.0637064 0.02111443 0.18046667 0.20390000 0.18530000 -0.01860000 0.921339554 0.002688731 FALSE TRUE
ENST00000502531 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding retained_intron 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 1.857157 2.242880 1.885998 0.5314475 0.1696005 -0.24881326 0.05348333 0.06570000 0.04543333 -0.02026667 0.870714422 0.002688731 FALSE TRUE
ENST00000503583 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding retained_intron 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 2.291223 2.882179 1.943215 0.5702852 0.1665956 -0.56630645 0.06695000 0.08366667 0.04643333 -0.03723333 0.615214302 0.002688731 FALSE FALSE
ENST00000508609 ENSG00000176783 HEK293_OSMI2_6hA HEK293_TMG_6hB RUFY1 protein_coding protein_coding 36.65997 36.73504 41.78794 3.783818 1.296943 0.1858822 3.806212 3.005725 7.242489 0.3718130 0.2845835 1.26597142 0.09882083 0.08283333 0.17330000 0.09046667 0.002688731 0.002688731 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000176783 E001 37.1535389 0.0060566330 6.364295e-03 4.152055e-02 5 179550554 179550712 159 + 1.461 1.660 0.680
ENSG00000176783 E002 33.8451391 0.0013085435 6.623768e-06 1.470416e-04 5 179550713 179550835 123 + 1.358 1.651 1.007
ENSG00000176783 E003 7.1466793 0.0042964096 9.710048e-03 5.686579e-02 5 179550836 179550837 2 + 0.706 1.033 1.260
ENSG00000176783 E004 21.3112486 0.0291856621 1.212712e-01 3.178726e-01 5 179550838 179550879 42 + 1.244 1.419 0.611
ENSG00000176783 E005 2.0530495 0.0181403337 1.260124e-01 3.255269e-01 5 179555650 179555790 141 + 0.305 0.576 1.439
ENSG00000176783 E006 0.9632605 0.0153787590 3.362659e-01   5 179559692 179559740 49 + 0.373 0.207 -1.155
ENSG00000176783 E007 34.9174272 0.0129414373 9.353628e-01 9.698572e-01 5 179559741 179559835 95 + 1.554 1.566 0.038
ENSG00000176783 E008 51.8555913 0.0069475001 3.806726e-01 6.127528e-01 5 179559836 179560024 189 + 1.694 1.754 0.201
ENSG00000176783 E009 165.4486639 0.0022256363 8.326786e-01 9.152976e-01 5 179560025 179560198 174 + 2.222 2.220 -0.004
ENSG00000176783 E010 138.3863711 0.0021480161 2.178220e-02 1.018690e-01 5 179562547 179562630 84 + 2.181 2.103 -0.261
ENSG00000176783 E011 111.6149949 0.0051530825 4.899036e-02 1.772070e-01 5 179562631 179562664 34 + 2.093 2.009 -0.281
ENSG00000176783 E012 2.4881556 0.0110229200 5.875302e-01 7.620106e-01 5 179562665 179562922 258 + 0.483 0.575 0.436
ENSG00000176783 E013 128.6261270 0.0035675684 3.652861e-02 1.456675e-01 5 179567461 179567509 49 + 2.150 2.073 -0.259
ENSG00000176783 E014 142.4560537 0.0039159597 1.248390e-03 1.177873e-02 5 179567510 179567562 53 + 2.217 2.091 -0.423
ENSG00000176783 E015 220.2552535 0.0009145502 4.826266e-09 2.438593e-07 5 179569302 179569425 124 + 2.417 2.266 -0.504
ENSG00000176783 E016 130.6506846 0.0003197925 1.958680e-05 3.758519e-04 5 179577075 179577112 38 + 2.181 2.055 -0.421
ENSG00000176783 E017 137.7618315 0.0004103216 8.837268e-04 8.961969e-03 5 179577113 179577136 24 + 2.191 2.096 -0.318
ENSG00000176783 E018 153.5600697 0.0020813426 7.362244e-02 2.320056e-01 5 179580947 179581012 66 + 2.216 2.163 -0.177
ENSG00000176783 E019 198.0558921 0.0030615047 1.404233e-01 3.481686e-01 5 179585796 179585865 70 + 2.320 2.276 -0.147
ENSG00000176783 E020 18.1451414 0.1001830808 7.768077e-01 8.827971e-01 5 179586331 179586475 145 + 1.257 1.301 0.154
ENSG00000176783 E021 11.0594107 0.0301997825 5.816104e-01 7.581796e-01 5 179586476 179586563 88 + 1.113 1.045 -0.248
ENSG00000176783 E022 1.7311612 0.0193682313 9.277742e-01 9.659520e-01 5 179589363 179589545 183 + 0.432 0.452 0.105
ENSG00000176783 E023 261.0696508 0.0045792078 1.175964e-02 6.548586e-02 5 179589546 179589647 102 + 2.460 2.375 -0.286
ENSG00000176783 E024 4.3013043 0.0063637254 6.176746e-01 7.822359e-01 5 179590861 179590958 98 + 0.761 0.697 -0.262
ENSG00000176783 E025 271.5022912 0.0046923336 1.508124e-01 3.634683e-01 5 179591625 179591741 117 + 2.457 2.413 -0.146
ENSG00000176783 E026 300.2656818 0.0004854707 5.702502e-01 7.504519e-01 5 179593478 179593645 168 + 2.469 2.490 0.069
ENSG00000176783 E027 182.6135662 0.0384389256 1.582939e-01 3.741866e-01 5 179594866 179594963 98 + 2.192 2.319 0.423
ENSG00000176783 E028 0.1723744 0.0435198236 5.383517e-01   5 179596560 179596561 2 + 0.001 0.116 8.004
ENSG00000176783 E029 173.6915043 0.0646086057 1.779678e-01 4.010920e-01 5 179596562 179596681 120 + 2.159 2.303 0.481
ENSG00000176783 E030 217.1189266 0.0023548828 5.135508e-01 7.106412e-01 5 179598692 179598821 130 + 2.326 2.355 0.098
ENSG00000176783 E031 219.1512706 0.0008259779 7.333961e-02 2.314744e-01 5 179601892 179601986 95 + 2.314 2.368 0.182
ENSG00000176783 E032 8.6631399 0.2155299543 3.148583e-01 5.550023e-01 5 179601987 179602571 585 + 0.803 1.099 1.113
ENSG00000176783 E033 177.7028107 0.0010872057 1.012790e-02 5.868538e-02 5 179605876 179605924 49 + 2.205 2.289 0.281
ENSG00000176783 E034 43.2565478 0.0881722447 4.631432e-01 6.752604e-01 5 179605925 179606584 660 + 1.565 1.705 0.479
ENSG00000176783 E035 33.6629118 0.0892491307 2.629167e-01 5.021341e-01 5 179606903 179607265 363 + 1.417 1.624 0.709
ENSG00000176783 E036 24.0823885 0.0973831929 4.404282e-01 6.590227e-01 5 179607266 179607485 220 + 1.315 1.460 0.501
ENSG00000176783 E037 16.8942946 0.0571797873 1.410165e-01 3.490685e-01 5 179607486 179607581 96 + 1.126 1.338 0.749
ENSG00000176783 E038 206.1749147 0.0016689567 3.741810e-03 2.769791e-02 5 179607582 179607659 78 + 2.265 2.360 0.317
ENSG00000176783 E039 17.3304534 0.0173592938 1.096228e-01 2.984270e-01 5 179608285 179608465 181 + 1.166 1.332 0.586
ENSG00000176783 E040 487.3575824 0.0001277768 4.608124e-05 7.758231e-04 5 179609376 179610012 637 + 2.649 2.720 0.239