ENSG00000176623

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000406452 ENSG00000176623 HEK293_OSMI2_6hA HEK293_TMG_6hB RMDN1 protein_coding protein_coding 20.45033 7.649264 29.35661 1.739562 1.226786 1.938899 6.0450563 2.8758014 7.004837 0.46352710 0.1549672 1.281438 0.32468333 0.38826667 0.23923333 -0.14903333 0.12098840 0.04961339 FALSE  
ENST00000430676 ENSG00000176623 HEK293_OSMI2_6hA HEK293_TMG_6hB RMDN1 protein_coding protein_coding 20.45033 7.649264 29.35661 1.739562 1.226786 1.938899 6.3667210 2.0918335 9.040464 0.93966772 0.4611822 2.106343 0.28380417 0.24686667 0.30940000 0.06253333 0.83294956 0.04961339 FALSE  
ENST00000517821 ENSG00000176623 HEK293_OSMI2_6hA HEK293_TMG_6hB RMDN1 protein_coding retained_intron 20.45033 7.649264 29.35661 1.739562 1.226786 1.938899 0.9409857 0.2882367 2.273084 0.28823672 0.5971827 2.936454 0.05207917 0.05593333 0.07610000 0.02016667 0.51617141 0.04961339    
ENST00000518390 ENSG00000176623 HEK293_OSMI2_6hA HEK293_TMG_6hB RMDN1 protein_coding retained_intron 20.45033 7.649264 29.35661 1.739562 1.226786 1.938899 1.5753098 0.3451070 3.602173 0.04656311 0.5639524 3.346541 0.06956250 0.04790000 0.12200000 0.07410000 0.04961339 0.04961339 FALSE  
ENST00000520719 ENSG00000176623 HEK293_OSMI2_6hA HEK293_TMG_6hB RMDN1 protein_coding protein_coding 20.45033 7.649264 29.35661 1.739562 1.226786 1.938899 1.9081914 0.6514849 2.186430 0.65148492 1.1560282 1.731380 0.08525833 0.05923333 0.07426667 0.01503333 0.80078840 0.04961339 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000176623 E001 0.3040503 0.0274424043 6.754634e-01   8 86468257 86468267 11 - 0.144 0.000 -8.837
ENSG00000176623 E002 3.2489261 0.2342739006 2.751056e-01 0.5151305404 8 86468268 86468423 156 - 0.524 0.726 0.885
ENSG00000176623 E003 4.9266972 0.1414441844 6.241210e-02 0.2081747522 8 86468424 86468707 284 - 0.614 0.966 1.408
ENSG00000176623 E004 5.9262482 0.0107165353 1.875841e-01 0.4138821644 8 86470218 86470410 193 - 0.744 0.922 0.694
ENSG00000176623 E005 1.5594070 0.0118251490 3.938789e-01 0.6234368467 8 86472348 86472348 1 - 0.339 0.492 0.831
ENSG00000176623 E006 1.6902752 0.0118197730 2.093652e-01 0.4411294186 8 86472349 86472352 4 - 0.339 0.560 1.151
ENSG00000176623 E007 16.7648302 0.0020116245 4.545434e-01 0.6691470463 8 86472353 86472479 127 - 1.188 1.252 0.228
ENSG00000176623 E008 194.5823663 0.0004730211 2.927244e-06 0.0000728158 8 86472480 86474020 1541 - 2.208 2.329 0.403
ENSG00000176623 E009 28.2070683 0.0115072694 2.005648e-01 0.4304103057 8 86474021 86474108 88 - 1.390 1.490 0.343
ENSG00000176623 E010 13.6551328 0.0303300638 5.986991e-01 0.7693631565 8 86474109 86474111 3 - 1.105 1.152 0.170
ENSG00000176623 E011 31.4661861 0.0071474487 5.551978e-01 0.7399224175 8 86474112 86474245 134 - 1.452 1.491 0.134
ENSG00000176623 E012 9.7279753 0.0210829795 2.003037e-01 0.4301248743 8 86474246 86474248 3 - 0.932 1.083 0.558
ENSG00000176623 E013 56.9930975 0.0008509224 3.518925e-01 0.5889428054 8 86474249 86474358 110 - 1.735 1.685 -0.169
ENSG00000176623 E014 2.1110944 0.0124316555 7.764716e-01 0.8825976983 8 86474412 86474657 246 - 0.443 0.493 0.248
ENSG00000176623 E015 97.9488336 0.0008765905 1.938210e-02 0.0937836868 8 86474820 86474914 95 - 1.977 1.879 -0.330
ENSG00000176623 E016 61.0939042 0.0076919710 7.774642e-02 0.2402838408 8 86474915 86474953 39 - 1.780 1.654 -0.424
ENSG00000176623 E017 4.0080137 0.0223413445 9.098509e-02 0.2654964341 8 86474954 86475050 97 - 0.727 0.413 -1.449
ENSG00000176623 E018 70.3937285 0.0058667859 4.148235e-01 0.6396956398 8 86477294 86477324 31 - 1.823 1.768 -0.184
ENSG00000176623 E019 6.8270472 0.2702664952 2.996791e-01 0.5400871097 8 86477325 86477453 129 - 0.912 0.631 -1.129
ENSG00000176623 E020 9.7490229 0.0804545826 1.013420e-01 0.2842594733 8 86478760 86478824 65 - 1.051 0.720 -1.270
ENSG00000176623 E021 9.4706712 0.0038953786 5.101896e-03 0.0351688276 8 86478825 86478922 98 - 1.052 0.671 -1.476
ENSG00000176623 E022 71.1808015 0.0007824068 1.667053e-01 0.3861480416 8 86478923 86478970 48 - 1.833 1.766 -0.225
ENSG00000176623 E023 58.6778149 0.0011224195 7.852015e-01 0.8876622027 8 86478971 86479010 40 - 1.741 1.725 -0.052
ENSG00000176623 E024 0.3228314 0.4504615888 8.270928e-01   8 86479011 86479011 1 - 0.145 0.000 -10.013
ENSG00000176623 E025 73.3400356 0.0069286758 7.657829e-02 0.2379043550 8 86480277 86480332 56 - 1.858 1.750 -0.364
ENSG00000176623 E026 0.6897577 0.0535590994 1.000000e+00   8 86480333 86480334 2 - 0.203 0.184 -0.171
ENSG00000176623 E027 0.7970432 0.0173214683 7.373514e-01   8 86484691 86484871 181 - 0.253 0.184 -0.581
ENSG00000176623 E028 59.4446731 0.0050218222 8.691281e-01 0.9354904230 8 86484872 86484961 90 - 1.744 1.728 -0.052
ENSG00000176623 E029 89.5018512 0.0014240774 4.622926e-01 0.6747332769 8 86486484 86486560 77 - 1.923 1.888 -0.118
ENSG00000176623 E030 57.8297400 0.0019571356 4.575674e-01 0.6714897974 8 86486561 86486561 1 - 1.738 1.694 -0.147
ENSG00000176623 E031 105.1354467 0.0010028046 7.688986e-01 0.8779613536 8 86486562 86486643 82 - 1.985 1.972 -0.047
ENSG00000176623 E032 98.2597986 0.0065539556 7.176319e-01 0.8466926247 8 86488552 86488639 88 - 1.957 1.929 -0.092
ENSG00000176623 E033 1.8835937 0.0981458034 9.492564e-01 0.9767289651 8 86494829 86494966 138 - 0.441 0.413 -0.150
ENSG00000176623 E034 0.3150090 0.0347866848 4.614320e-01   8 86504830 86505299 470 - 0.078 0.184 1.421
ENSG00000176623 E035 0.6953672 0.2368821961 3.212903e-01   8 86505300 86505379 80 - 0.257 0.000 -11.299
ENSG00000176623 E036 99.0804344 0.0039576106 1.750060e-01 0.3971666492 8 86506995 86507112 118 - 1.937 1.999 0.209
ENSG00000176623 E037 3.0942513 0.0081773011 7.968133e-01 0.8944700486 8 86508116 86508491 376 - 0.576 0.619 0.191
ENSG00000176623 E038 63.1809575 0.0008154496 1.590376e-02 0.0814310761 8 86508492 86508686 195 - 1.732 1.845 0.383
ENSG00000176623 E039 3.9931445 0.0675421789 8.049355e-01 0.8991715400 8 86514242 86514357 116 - 0.677 0.619 -0.248