ENSG00000176531

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000595498 ENSG00000176531 HEK293_OSMI2_6hA HEK293_TMG_6hB PHLDB3 protein_coding retained_intron 5.746261 8.172016 3.209388 1.387327 0.1550079 -1.34567 0.3503352 0.6958486 0.0000000 0.1244294 0.0000000 -6.1412868 0.05233750 0.09583333 0.00000000 -0.09583333 0.001883215 0.001883215 FALSE  
ENST00000596902 ENSG00000176531 HEK293_OSMI2_6hA HEK293_TMG_6hB PHLDB3 protein_coding retained_intron 5.746261 8.172016 3.209388 1.387327 0.1550079 -1.34567 0.3345658 0.3223234 0.1771399 0.1843187 0.0898240 -0.8284704 0.06194167 0.03486667 0.05493333 0.02006667 0.945656063 0.001883215 FALSE  
MSTRG.17245.4 ENSG00000176531 HEK293_OSMI2_6hA HEK293_TMG_6hB PHLDB3 protein_coding   5.746261 8.172016 3.209388 1.387327 0.1550079 -1.34567 2.0886295 3.2575328 1.9318069 0.6110873 0.2592442 -0.7508020 0.38537500 0.41070000 0.61206667 0.20136667 0.548315682 0.001883215 FALSE  
MSTRG.17245.5 ENSG00000176531 HEK293_OSMI2_6hA HEK293_TMG_6hB PHLDB3 protein_coding   5.746261 8.172016 3.209388 1.387327 0.1550079 -1.34567 2.1731444 3.3231787 0.3338499 1.2339354 0.2175084 -3.2770477 0.34708333 0.38256667 0.09830000 -0.28426667 0.325408650 0.001883215 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000176531 E001 0.315009 0.0338662768 0.391094024   19 43474954 43475102 149 - 0.200 0.071 -1.716
ENSG00000176531 E002 1.840660 0.1698971008 0.133634118 0.337506120 19 43475103 43475118 16 - 0.652 0.312 -1.734
ENSG00000176531 E003 2.711696 0.1081109093 0.625307728 0.787503035 19 43475119 43475125 7 - 0.594 0.476 -0.552
ENSG00000176531 E004 79.996788 0.0006222954 0.491581551 0.695044990 19 43475126 43475544 419 - 1.812 1.843 0.107
ENSG00000176531 E005 44.451350 0.0010489026 0.100445734 0.282592397 19 43478047 43478132 86 - 1.658 1.563 -0.324
ENSG00000176531 E006 37.356726 0.0014290773 0.982017697 0.992776117 19 43479377 43479449 73 - 1.513 1.516 0.009
ENSG00000176531 E007 20.391317 0.0020392878 0.363891429 0.598940272 19 43479450 43479453 4 - 1.194 1.278 0.295
ENSG00000176531 E008 22.643794 0.0021494413 0.732338809 0.855635954 19 43479454 43479491 38 - 1.282 1.313 0.107
ENSG00000176531 E009 17.313278 0.0024154759 0.959634057 0.981709111 19 43479492 43479512 21 - 1.194 1.201 0.026
ENSG00000176531 E010 18.427817 0.0021617835 0.415830864 0.640409484 19 43479513 43479593 81 - 1.160 1.239 0.279
ENSG00000176531 E011 15.566730 0.0027049336 0.860066980 0.930399942 19 43486266 43486322 57 - 1.160 1.145 -0.055
ENSG00000176531 E012 27.268023 0.0014791235 0.415440068 0.640158958 19 43486609 43486696 88 - 1.332 1.397 0.227
ENSG00000176531 E013 31.995557 0.0079733783 0.535679678 0.726089383 19 43486780 43486870 91 - 1.409 1.453 0.154
ENSG00000176531 E014 2.553552 0.1817409073 0.922996924 0.963806957 19 43486871 43487023 153 - 0.527 0.492 -0.164
ENSG00000176531 E015 34.898085 0.0110298802 0.394631732 0.624028536 19 43487024 43487123 100 - 1.428 1.492 0.220
ENSG00000176531 E016 35.484201 0.0041316288 0.557934068 0.741805206 19 43494702 43494815 114 - 1.455 1.495 0.137
ENSG00000176531 E017 29.460286 0.0015296167 0.194955671 0.423288802 19 43495256 43495339 84 - 1.481 1.389 -0.319
ENSG00000176531 E018 49.626602 0.0008399926 0.832914239 0.915443974 19 43495495 43495605 111 - 1.646 1.636 -0.036
ENSG00000176531 E019 1.225834 0.1841839635 0.136240094   19 43495606 43495620 15 - 0.001 0.357 9.898
ENSG00000176531 E020 2.071023 0.0254273300 0.178432891 0.401835442 19 43495621 43495694 74 - 0.200 0.472 1.746
ENSG00000176531 E021 6.251838 0.0190173847 0.000900556 0.009099734 19 43496018 43497117 1100 - 1.104 0.657 -1.726
ENSG00000176531 E022 64.645753 0.0006760353 0.510057718 0.708012366 19 43497118 43497279 162 - 1.775 1.744 -0.104
ENSG00000176531 E023 55.870559 0.0008610359 0.513669449 0.710712781 19 43497748 43497876 129 - 1.711 1.677 -0.114
ENSG00000176531 E024 4.406090 0.1938870751 0.295802194 0.536294863 19 43501530 43501733 204 - 0.800 0.614 -0.771
ENSG00000176531 E025 47.678648 0.0008627653 0.585551792 0.760646735 19 43501734 43501871 138 - 1.592 1.625 0.114
ENSG00000176531 E026 33.575860 0.0201887297 0.786527083 0.888425879 19 43502101 43502165 65 - 1.489 1.469 -0.069
ENSG00000176531 E027 27.198617 0.0314791850 0.928260888 0.966141711 19 43502166 43502193 28 - 1.366 1.393 0.094
ENSG00000176531 E028 33.741350 0.0030507245 0.484735404 0.690345649 19 43502194 43502283 90 - 1.437 1.492 0.189
ENSG00000176531 E029 53.384490 0.0107374511 0.827328558 0.912252114 19 43503906 43504132 227 - 1.675 1.668 -0.022
ENSG00000176531 E030 5.792842 0.0054674275 0.148127675 0.359653676 19 43504133 43504238 106 - 0.594 0.825 0.956
ENSG00000176531 E031 0.000000       19 43504239 43504414 176 -      
ENSG00000176531 E032 3.093098 0.0079113782 0.823786595 0.910171503 19 43504589 43504935 347 - 0.524 0.564 0.186