ENSG00000176142

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000473684 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding nonsense_mediated_decay 31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 1.872155 0.5725333 3.893538 0.2467901 0.2683851 2.7443700 0.05498750 0.02770000 0.09033333 0.06263333 0.03621968 0.03141171   FALSE
MSTRG.23488.10 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding   31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 2.989536 1.0711958 3.780013 0.5631056 1.0665142 1.8095748 0.09288750 0.06250000 0.08733333 0.02483333 0.86737129 0.03141171 FALSE TRUE
MSTRG.23488.5 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding   31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 5.772994 2.1970953 8.976041 0.3512079 0.3331402 2.0255367 0.17410833 0.12403333 0.20843333 0.08440000 0.03141171 0.03141171 FALSE TRUE
MSTRG.23488.7 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding   31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 2.055237 1.7292232 2.085148 0.6952188 1.0441692 0.2686092 0.07807083 0.08786667 0.04776667 -0.04010000 0.53820659 0.03141171 FALSE TRUE
MSTRG.23488.8 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding   31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 5.692366 4.5466604 7.003829 1.3632197 1.4765671 0.6222253 0.18800833 0.23833333 0.16330000 -0.07503333 0.59753394 0.03141171 FALSE TRUE
MSTRG.23488.9 ENSG00000176142 HEK293_OSMI2_6hA HEK293_TMG_6hB TMEM39A protein_coding   31.95937 18.45091 43.07167 4.474397 0.6487757 1.2226 6.885378 5.1189804 10.384421 1.0049494 0.6815930 1.0190654 0.21830000 0.28346667 0.24166667 -0.04180000 0.77140012 0.03141171 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000176142 E001 4.1280589 0.0538409890 5.525966e-01 7.381066e-01 3 119428949 119429499 551 - 0.657 0.737 0.334
ENSG00000176142 E002 111.5870914 0.0508480177 2.596736e-02 1.152120e-01 3 119429500 119430867 1368 - 2.115 1.825 -0.974
ENSG00000176142 E003 167.9694324 0.0024623791 2.154224e-12 2.091691e-10 3 119430868 119431562 695 - 2.288 1.998 -0.969
ENSG00000176142 E004 83.2877092 0.0021559199 1.872166e-06 4.918579e-05 3 119431563 119431753 191 - 1.976 1.733 -0.819
ENSG00000176142 E005 71.8354597 0.0017547026 7.189969e-02 2.286002e-01 3 119431754 119431877 124 - 1.871 1.773 -0.328
ENSG00000176142 E006 42.5388694 0.0010163819 9.845632e-01 9.941209e-01 3 119431878 119431929 52 - 1.617 1.605 -0.039
ENSG00000176142 E007 240.2683909 0.0002875589 6.397076e-02 2.116114e-01 3 119431930 119432214 285 - 2.344 2.379 0.116
ENSG00000176142 E008 141.7405978 0.0006728523 5.276143e-03 3.606111e-02 3 119434762 119434882 121 - 2.097 2.178 0.271
ENSG00000176142 E009 16.3929817 0.0166199603 1.170408e-01 3.109235e-01 3 119435755 119435935 181 - 1.266 1.101 -0.589
ENSG00000176142 E010 8.9273271 0.0039010653 4.237103e-01 6.463862e-01 3 119436589 119436790 202 - 1.009 0.906 -0.383
ENSG00000176142 E011 190.7497403 0.0002805529 7.339426e-01 8.566023e-01 3 119436791 119436943 153 - 2.258 2.257 -0.003
ENSG00000176142 E012 119.9178787 0.0007675534 9.871900e-01 9.954314e-01 3 119436944 119436978 35 - 2.062 2.053 -0.032
ENSG00000176142 E013 231.6241930 0.0002389661 1.070688e-01 2.940906e-01 3 119437755 119437933 179 - 2.330 2.358 0.096
ENSG00000176142 E014 244.1477254 0.0009826561 3.846054e-01 6.161662e-01 3 119437934 119438103 170 - 2.357 2.372 0.049
ENSG00000176142 E015 4.3272378 0.0063710251 7.746987e-01 8.815678e-01 3 119446642 119447017 376 - 0.700 0.733 0.138
ENSG00000176142 E016 115.0634846 0.0003807259 9.081392e-01 9.562137e-01 3 119447018 119447018 1 - 2.042 2.028 -0.049
ENSG00000176142 E017 239.1150401 0.0003589280 8.201365e-01 9.081572e-01 3 119447019 119447172 154 - 2.361 2.345 -0.054
ENSG00000176142 E018 0.2852693 0.2626627239 5.432388e-01   3 119451209 119451317 109 - 0.166 0.000 -8.977
ENSG00000176142 E019 144.2628849 0.0002980377 1.574325e-01 3.728673e-01 3 119452447 119452508 62 - 2.156 2.100 -0.185
ENSG00000176142 E020 98.4576159 0.0020413755 2.162437e-01 4.489930e-01 3 119452509 119452530 22 - 1.992 1.929 -0.213
ENSG00000176142 E021 139.9467895 0.0003599992 6.802236e-01 8.228747e-01 3 119458018 119458083 66 - 2.132 2.108 -0.080
ENSG00000176142 E022 178.9874362 0.0005020606 6.624727e-02 2.166118e-01 3 119458084 119458184 101 - 2.216 2.259 0.143
ENSG00000176142 E023 138.2755103 0.0007383916 6.779587e-03 4.361263e-02 3 119458185 119458240 56 - 2.090 2.169 0.265
ENSG00000176142 E024 194.4972888 0.0002372430 2.997822e-03 2.338643e-02 3 119461962 119462104 143 - 2.240 2.307 0.225
ENSG00000176142 E025 95.2971838 0.0004485318 8.206785e-02 2.488726e-01 3 119462105 119462148 44 - 1.939 1.994 0.184
ENSG00000176142 E026 160.5723458 0.0004301962 5.947583e-04 6.534069e-03 3 119463336 119463472 137 - 2.150 2.240 0.301
ENSG00000176142 E027 109.1703804 0.0004738808 1.206680e-01 3.169224e-01 3 119463473 119463605 133 - 2.003 2.047 0.149
ENSG00000176142 E028 26.1155077 0.0248989713 7.517988e-01 8.678430e-01 3 119463606 119463683 78 - 1.412 1.422 0.035
ENSG00000176142 E029 3.5013082 0.0126357342 2.303423e-01 4.655351e-01 3 119468735 119468744 10 - 0.556 0.734 0.767
ENSG00000176142 E030 4.0184313 0.0401101054 9.790935e-02 2.781262e-01 3 119468745 119468840 96 - 0.557 0.832 1.152