ENSG00000176105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314574 ENSG00000176105 HEK293_OSMI2_6hA HEK293_TMG_6hB YES1 protein_coding protein_coding 9.575897 3.002829 17.4374 0.6886414 0.8523155 2.533822 6.0300455 1.39809017 9.167853 0.27352308 0.4145238 2.704417 0.60470000 0.5547667 0.53076667 -0.02400000 0.991138287 0.002667432 FALSE  
ENST00000577961 ENSG00000176105 HEK293_OSMI2_6hA HEK293_TMG_6hB YES1 protein_coding protein_coding 9.575897 3.002829 17.4374 0.6886414 0.8523155 2.533822 1.5464151 1.53138784 5.384619 0.76633448 0.7719663 1.807291 0.25062083 0.4244333 0.30733333 -0.11710000 0.980827741 0.002667432 FALSE  
ENST00000584307 ENSG00000176105 HEK293_OSMI2_6hA HEK293_TMG_6hB YES1 protein_coding protein_coding 9.575897 3.002829 17.4374 0.6886414 0.8523155 2.533822 0.9635289 0.00000000 1.460927 0.00000000 0.5721417 7.200582 0.07944167 0.0000000 0.08176667 0.08176667 0.002667432 0.002667432 FALSE  
MSTRG.15391.4 ENSG00000176105 HEK293_OSMI2_6hA HEK293_TMG_6hB YES1 protein_coding   9.575897 3.002829 17.4374 0.6886414 0.8523155 2.533822 0.9827940 0.07335051 1.329364 0.03839331 0.2739960 4.006214 0.06209167 0.0208000 0.07516667 0.05436667 0.212581157 0.002667432 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000176105 E001 117.9205490 1.381136028 3.206709e-01 5.602834e-01 18 721588 722314 727 - 1.865 2.222 1.198
ENSG00000176105 E002 548.8161579 0.001134445 1.529768e-06 4.118417e-05 18 722315 724632 2318 - 2.592 2.719 0.424
ENSG00000176105 E003 55.7201573 0.048827642 3.211360e-01 5.606633e-01 18 732834 732965 132 - 1.607 1.747 0.475
ENSG00000176105 E004 61.6414906 0.947087759 4.418544e-01 6.599922e-01 18 736808 736961 154 - 1.642 1.797 0.526
ENSG00000176105 E005 48.3760139 0.040344317 7.597941e-01 8.724586e-01 18 739735 739811 77 - 1.565 1.607 0.143
ENSG00000176105 E006 102.7692478 0.008414049 4.394895e-03 3.135020e-02 18 742918 743097 180 - 1.914 1.783 -0.442
ENSG00000176105 E007 89.1224595 0.012864374 2.386784e-03 1.960298e-02 18 743260 743415 156 - 1.856 1.679 -0.599
ENSG00000176105 E008 89.2052893 0.006235200 1.246914e-03 1.177134e-02 18 745708 745857 150 - 1.855 1.696 -0.538
ENSG00000176105 E009 79.1648517 0.002592803 5.511727e-03 3.728417e-02 18 745948 746051 104 - 1.799 1.679 -0.407
ENSG00000176105 E010 75.1483219 0.016301699 4.916099e-02 1.775972e-01 18 747920 748018 99 - 1.775 1.660 -0.388
ENSG00000176105 E011 42.0913330 0.022512914 1.517356e-01 3.648541e-01 18 751705 751723 19 - 1.527 1.422 -0.362
ENSG00000176105 E012 67.7383630 0.025193572 4.603334e-02 1.701236e-01 18 751724 751804 81 - 1.734 1.592 -0.481
ENSG00000176105 E013 74.5342171 0.013908844 2.999732e-02 1.273304e-01 18 756557 756676 120 - 1.772 1.648 -0.421
ENSG00000176105 E014 64.5161551 0.019853980 4.843911e-02 1.760304e-01 18 756677 756835 159 - 1.711 1.573 -0.472
ENSG00000176105 E015 0.2852693 0.181948823 1.000000e+00   18 775058 775112 55 - 0.108 0.001 -7.862
ENSG00000176105 E016 0.0000000       18 775189 775266 78 -      
ENSG00000176105 E017 0.0000000       18 787903 787986 84 -      
ENSG00000176105 E018 22.5499278 0.017217952 2.250375e-01 4.594843e-01 18 812114 812357 244 - 1.267 1.171 -0.341
ENSG00000176105 E019 1.8552254 0.017929666 6.802437e-02 2.206397e-01 18 812384 812546 163 - 0.432 0.000 -11.456