ENSG00000175792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000322623 ENSG00000175792 HEK293_OSMI2_6hA HEK293_TMG_6hB RUVBL1 protein_coding protein_coding 176.6162 183.4296 128.5301 34.99826 6.299846 -0.5130869 138.951696 158.823230 79.13342 34.750387 5.891231 -1.004971 0.7614458 0.85533333 0.61423333 -0.24110000 7.203959e-04 4.622346e-23 FALSE TRUE
MSTRG.23630.20 ENSG00000175792 HEK293_OSMI2_6hA HEK293_TMG_6hB RUVBL1 protein_coding   176.6162 183.4296 128.5301 34.99826 6.299846 -0.5130869 5.693758 0.000000 10.55040 0.000000 2.855789 10.044449 0.0390000 0.00000000 0.08086667 0.08086667 4.622346e-23 4.622346e-23 TRUE TRUE
MSTRG.23630.6 ENSG00000175792 HEK293_OSMI2_6hA HEK293_TMG_6hB RUVBL1 protein_coding   176.6162 183.4296 128.5301 34.99826 6.299846 -0.5130869 15.114280 7.620284 24.11011 1.891055 1.799203 1.660428 0.1025542 0.04883333 0.18986667 0.14103333 2.643160e-02 4.622346e-23 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175792 E001 0.1308682 3.078697e-02 8.496805e-01   3 128064778 128064781 4 - 0.000 0.093 8.549
ENSG00000175792 E002 0.1308682 3.078697e-02 8.496805e-01   3 128064782 128064784 3 - 0.000 0.093 10.051
ENSG00000175792 E003 20.4060945 3.452958e-01 5.263608e-01 7.194276e-01 3 128064785 128065060 276 - 1.260 1.338 0.270
ENSG00000175792 E004 20.0754408 3.056663e-01 4.484787e-01 6.645792e-01 3 128065061 128065220 160 - 1.227 1.343 0.404
ENSG00000175792 E005 7.5849189 3.618612e-01 2.796767e-01 5.197643e-01 3 128068636 128068913 278 - 1.144 0.697 -1.701
ENSG00000175792 E006 2.3906163 2.332506e-01 7.244164e-01 8.507903e-01 3 128074758 128074839 82 - 0.561 0.492 -0.328
ENSG00000175792 E007 0.0000000       3 128080763 128080809 47 -      
ENSG00000175792 E008 3.2108508 8.119728e-02 7.740062e-01 8.811517e-01 3 128080810 128080960 151 - 0.557 0.637 0.357
ENSG00000175792 E009 5.4051477 5.608896e-02 6.039973e-01 7.728584e-01 3 128080961 128080962 2 - 0.847 0.775 -0.285
ENSG00000175792 E010 657.4784309 1.746758e-03 2.502185e-12 2.403442e-10 3 128080963 128081181 219 - 2.663 2.854 0.634
ENSG00000175792 E011 1368.6287174 8.777599e-04 3.040505e-06 7.518166e-05 3 128081182 128081409 228 - 3.054 3.144 0.299
ENSG00000175792 E012 22.8264339 1.266910e-02 7.690972e-01 8.781180e-01 3 128081410 128082482 1073 - 1.332 1.361 0.103
ENSG00000175792 E013 1149.6353549 1.234608e-04 7.534653e-01 8.688101e-01 3 128082483 128082574 92 - 3.030 3.040 0.031
ENSG00000175792 E014 39.2325330 3.149893e-02 4.214871e-01 6.447442e-01 3 128082575 128083601 1027 - 1.526 1.612 0.295
ENSG00000175792 E015 13.9696076 6.661305e-02 5.728145e-01 7.522457e-01 3 128083602 128083772 171 - 1.091 1.184 0.332
ENSG00000175792 E016 29.4844531 2.477134e-02 3.358808e-01 5.743080e-01 3 128083773 128084050 278 - 1.398 1.498 0.344
ENSG00000175792 E017 6.2701347 1.644239e-01 4.931496e-01 6.960798e-01 3 128084051 128084075 25 - 0.765 0.883 0.460
ENSG00000175792 E018 20.1887931 9.979047e-02 3.963551e-01 6.254085e-01 3 128084076 128084842 767 - 1.188 1.358 0.594
ENSG00000175792 E019 8.2767022 4.461318e-02 2.989641e-01 5.394184e-01 3 128084843 128085131 289 - 0.849 1.002 0.580
ENSG00000175792 E020 1275.4993936 7.376382e-05 8.623503e-01 9.316199e-01 3 128087706 128087806 101 - 3.077 3.084 0.023
ENSG00000175792 E021 652.8940998 8.252465e-04 9.763317e-01 9.899540e-01 3 128087807 128087808 2 - 2.789 2.794 0.018
ENSG00000175792 E022 7.8589242 1.299528e-02 4.249781e-01 6.472467e-01 3 128087809 128087844 36 - 0.986 0.888 -0.368
ENSG00000175792 E023 0.5474829 1.331938e-01 2.401507e-01   3 128088179 128088254 76 - 0.000 0.238 11.025
ENSG00000175792 E024 6.9681863 2.791362e-02 1.066329e-01 2.933583e-01 3 128091476 128091582 107 - 1.008 0.795 -0.807
ENSG00000175792 E025 4.2091659 6.287705e-03 6.141887e-02 2.059613e-01 3 128092784 128092854 71 - 0.850 0.588 -1.080
ENSG00000175792 E026 5.4875081 4.777157e-03 2.232128e-03 1.860176e-02 3 128092855 128092961 107 - 1.005 0.614 -1.552
ENSG00000175792 E027 3.8520535 6.229945e-03 5.484776e-04 6.116634e-03 3 128092962 128093006 45 - 0.923 0.428 -2.138
ENSG00000175792 E028 1778.5098088 1.178258e-04 4.827255e-01 6.888899e-01 3 128097300 128097498 199 - 3.226 3.225 -0.002
ENSG00000175792 E029 1035.1938460 5.327200e-04 2.051945e-01 4.361404e-01 3 128098882 128098945 64 - 2.999 2.988 -0.036
ENSG00000175792 E030 1372.9316352 1.301149e-04 5.859502e-02 1.996396e-01 3 128100595 128100742 148 - 3.123 3.109 -0.048
ENSG00000175792 E031 659.4577915 1.511948e-04 1.475790e-01 3.588360e-01 3 128100743 128100744 2 - 2.807 2.790 -0.054
ENSG00000175792 E032 1292.3887044 6.827473e-05 7.202958e-02 2.288674e-01 3 128101559 128101648 90 - 3.096 3.082 -0.045
ENSG00000175792 E033 1661.1576568 8.766076e-05 4.936083e-06 1.138896e-04 3 128104773 128104924 152 - 3.221 3.184 -0.125
ENSG00000175792 E034 1436.6568377 1.113761e-04 4.019572e-04 4.751219e-03 3 128112888 128113020 133 - 3.153 3.122 -0.103
ENSG00000175792 E035 1074.2709817 3.419067e-04 5.795729e-01 7.568926e-01 3 128119328 128119414 87 - 3.008 3.007 -0.002
ENSG00000175792 E036 1015.3314256 1.989827e-04 3.110360e-01 5.514258e-01 3 128123584 128123850 267 - 2.971 2.990 0.063
ENSG00000175792 E037 4.3768407 1.579219e-02 5.033264e-01 7.030898e-01 3 128148177 128148312 136 - 0.762 0.664 -0.402
ENSG00000175792 E038 26.3050123 3.774832e-02 3.907030e-01 6.209386e-01 3 128153203 128153914 712 - 1.475 1.376 -0.342