ENSG00000175711

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320865 ENSG00000175711 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GNTL1 protein_coding protein_coding 6.945941 9.769162 3.952811 0.9287357 0.2101504 -1.303187 0.5207879 0.6948390 0.1522440 0.2352120 0.07758968 -2.1191287 0.07064583 0.0775000 0.03866667 -0.03883333 0.804401947 0.001648033 FALSE TRUE
ENST00000571301 ENSG00000175711 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GNTL1 protein_coding retained_intron 6.945941 9.769162 3.952811 0.9287357 0.2101504 -1.303187 0.4737702 0.6962124 0.2363338 0.3077821 0.03619645 -1.5194874 0.06905417 0.0793000 0.05953333 -0.01976667 1.000000000 0.001648033 TRUE TRUE
MSTRG.15383.15 ENSG00000175711 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GNTL1 protein_coding   6.945941 9.769162 3.952811 0.9287357 0.2101504 -1.303187 1.0816038 1.0873694 1.4048907 0.1460942 0.21216888 0.3666413 0.18420000 0.1135000 0.35296667 0.23946667 0.001648033 0.001648033 FALSE TRUE
MSTRG.15383.5 ENSG00000175711 HEK293_OSMI2_6hA HEK293_TMG_6hB B3GNTL1 protein_coding   6.945941 9.769162 3.952811 0.9287357 0.2101504 -1.303187 3.7910236 5.9277047 1.5728877 1.1738159 0.08231534 -1.9073465 0.52783750 0.5965667 0.40210000 -0.19446667 0.429246092 0.001648033 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175711 E001 0.0000000       17 82942149 82942154 6 -      
ENSG00000175711 E002 5.9002400 0.005337495 8.677109e-01 9.346839e-01 17 82942155 82942464 310 - 0.731 0.765 0.140
ENSG00000175711 E003 5.1727480 0.006060853 8.583357e-01 9.295002e-01 17 82942465 82942591 127 - 0.731 0.713 -0.075
ENSG00000175711 E004 3.1885439 0.009546706 2.134353e-01 4.457483e-01 17 82942592 82942654 63 - 0.352 0.601 1.257
ENSG00000175711 E005 1.6717112 0.034894697 3.836679e-01 6.152911e-01 17 82942655 82942662 8 - 0.211 0.399 1.266
ENSG00000175711 E006 1.5408431 0.118053365 4.934614e-01 6.962504e-01 17 82942663 82942682 20 - 0.210 0.372 1.121
ENSG00000175711 E007 8.1910460 0.173309047 1.608104e-01 3.779835e-01 17 82942683 82943050 368 - 0.542 0.941 1.637
ENSG00000175711 E008 5.3853882 0.102939570 5.650570e-01 7.468144e-01 17 82943051 82943295 245 - 0.614 0.755 0.590
ENSG00000175711 E009 7.1234238 0.268111075 9.479688e-01 9.762462e-01 17 82943296 82943790 495 - 0.772 0.842 0.274
ENSG00000175711 E010 1.2858316 0.199660130 3.422813e-01   17 82943791 82943795 5 - 0.458 0.264 -1.163
ENSG00000175711 E011 3.3889496 0.007695329 3.906188e-01 6.208966e-01 17 82943796 82943821 26 - 0.677 0.543 -0.590
ENSG00000175711 E012 31.3256116 0.171287379 3.708464e-01 6.046125e-01 17 82943822 82944049 228 - 1.323 1.445 0.422
ENSG00000175711 E013 18.2166875 0.006557973 1.393522e-01 3.465230e-01 17 82946879 82946893 15 - 1.066 1.236 0.608
ENSG00000175711 E014 25.7772184 0.016963868 1.902613e-01 4.172880e-01 17 82946894 82946959 66 - 1.221 1.377 0.544
ENSG00000175711 E015 20.5879836 0.025585861 3.730599e-01 6.065501e-01 17 82946960 82946983 24 - 1.150 1.281 0.464
ENSG00000175711 E016 42.8278721 0.160584577 9.296970e-01 9.668568e-01 17 82946984 82949948 2965 - 1.489 1.566 0.262
ENSG00000175711 E017 33.1790133 0.033108237 3.905310e-02 1.523363e-01 17 82956695 82956769 75 - 1.222 1.495 0.949
ENSG00000175711 E018 0.3503582 0.036730424 3.234522e-01   17 82956770 82956801 32 - 0.211 0.067 -1.914
ENSG00000175711 E019 31.1908108 0.007801289 4.491209e-02 1.673859e-01 17 82957181 82957249 69 - 1.267 1.462 0.675
ENSG00000175711 E020 38.1220414 0.001387824 3.258941e-02 1.349302e-01 17 82957359 82957494 136 - 1.372 1.540 0.580
ENSG00000175711 E021 0.4646582 0.021768165 5.833233e-01   17 82960359 82960375 17 - 0.211 0.125 -0.915
ENSG00000175711 E022 1.0767527 0.015747495 6.097027e-01   17 82960376 82960486 111 - 0.353 0.262 -0.596
ENSG00000175711 E023 31.0512520 0.002173611 2.539241e-01 4.922957e-01 17 82961057 82961181 125 - 1.336 1.438 0.355
ENSG00000175711 E024 0.0000000       17 82961182 82961332 151 -      
ENSG00000175711 E025 31.2012918 0.001219825 9.242944e-01 9.644991e-01 17 82965651 82965746 96 - 1.405 1.425 0.067
ENSG00000175711 E026 35.2743795 0.003302803 7.989171e-01 8.956526e-01 17 83005115 83005210 96 - 1.474 1.467 -0.025
ENSG00000175711 E027 0.1723744 0.034176256 1.000000e+00   17 83005575 83005671 97 - 0.000 0.067 8.222
ENSG00000175711 E028 6.4196327 0.004839263 1.942523e-02 9.393350e-02 17 83005981 83006988 1008 - 1.017 0.725 -1.121
ENSG00000175711 E029 1.0950385 0.528689112 6.066853e-01   17 83011428 83011503 76 - 0.360 0.230 -0.882
ENSG00000175711 E030 8.0200029 0.004031252 3.931439e-08 1.607630e-06 17 83011918 83012328 411 - 1.268 0.653 -2.326
ENSG00000175711 E031 32.7717683 0.016472968 3.992974e-01 6.276891e-01 17 83014454 83014519 66 - 1.492 1.423 -0.240
ENSG00000175711 E032 0.6783511 0.019387492 3.985577e-01   17 83030761 83030902 142 - 0.000 0.222 10.222
ENSG00000175711 E033 34.0369369 0.033128880 9.262345e-01 9.652331e-01 17 83035035 83035099 65 - 1.463 1.452 -0.040
ENSG00000175711 E034 41.2218579 0.018170550 8.663506e-02 2.576177e-01 17 83048471 83048570 100 - 1.638 1.504 -0.457
ENSG00000175711 E035 28.6391008 0.007394139 1.394855e-01 3.467093e-01 17 83048669 83048706 38 - 1.465 1.357 -0.372
ENSG00000175711 E036 27.9670766 0.017945982 1.860788e-01 4.119336e-01 17 83048707 83048732 26 - 1.456 1.344 -0.387
ENSG00000175711 E037 30.8621525 0.001466754 9.598635e-03 5.638816e-02 17 83048733 83048785 53 - 1.542 1.373 -0.580
ENSG00000175711 E038 0.7664957 0.017883882 5.715126e-02   17 83048786 83049035 250 - 0.459 0.125 -2.498
ENSG00000175711 E039 0.0000000       17 83049036 83049166 131 -      
ENSG00000175711 E040 22.4391199 0.001833502 1.261423e-01 3.257202e-01 17 83051737 83051809 73 - 1.372 1.258 -0.398