ENSG00000175662

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379504 ENSG00000175662 HEK293_OSMI2_6hA HEK293_TMG_6hB TOM1L2 protein_coding protein_coding 10.40586 18.3532 6.811128 1.593817 0.07987845 -1.428736 7.6145266 13.2795732 4.6887646 1.4336339 0.20799023 -1.499941 0.72847917 0.7208 0.68826667 -0.03253333 0.871575688 0.001055894 FALSE TRUE
ENST00000486413 ENSG00000175662 HEK293_OSMI2_6hA HEK293_TMG_6hB TOM1L2 protein_coding retained_intron 10.40586 18.3532 6.811128 1.593817 0.07987845 -1.428736 0.7038328 1.5966502 0.3474495 0.1743561 0.11160480 -2.168245 0.06384583 0.0901 0.05103333 -0.03906667 0.610555838 0.001055894   FALSE
ENST00000537091 ENSG00000175662 HEK293_OSMI2_6hA HEK293_TMG_6hB TOM1L2 protein_coding retained_intron 10.40586 18.3532 6.811128 1.593817 0.07987845 -1.428736 0.2179989 0.2538725 0.5336751 0.0625935 0.03881061 1.042904 0.02669583 0.0143 0.07840000 0.06410000 0.001055894 0.001055894 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175662 E001 883.0962594 0.0002121964 5.743256e-13 6.145791e-11 17 17843511 17846824 3314 - 2.799 2.894 0.318
ENSG00000175662 E002 47.8657240 0.0088998373 6.575034e-01 8.083397e-01 17 17846825 17846848 24 - 1.640 1.607 -0.115
ENSG00000175662 E003 174.6258215 0.0002887967 6.803060e-01 8.229157e-01 17 17846849 17847333 485 - 2.161 2.176 0.050
ENSG00000175662 E004 43.3299261 0.0008477300 4.631460e-01 6.752604e-01 17 17847334 17847348 15 - 1.535 1.584 0.167
ENSG00000175662 E005 70.5817363 0.0005325875 2.370000e-01 4.730891e-01 17 17847349 17847445 97 - 1.734 1.795 0.209
ENSG00000175662 E006 46.0566060 0.0008647775 3.666911e-01 6.012841e-01 17 17847446 17847468 23 - 1.557 1.615 0.198
ENSG00000175662 E007 74.8346489 0.0006945892 4.560272e-01 6.702895e-01 17 17847469 17847551 83 - 1.782 1.821 0.132
ENSG00000175662 E008 46.7473758 0.0026198319 6.674695e-01 8.146123e-01 17 17847552 17847568 17 - 1.590 1.621 0.104
ENSG00000175662 E009 96.4479022 0.0015227752 5.161338e-02 1.835554e-01 17 17847569 17847783 215 - 1.848 1.940 0.310
ENSG00000175662 E010 53.8367040 0.0097403910 5.528616e-01 7.382842e-01 17 17848823 17848859 37 - 1.632 1.674 0.142
ENSG00000175662 E011 3.2848005 0.0078828440 3.629590e-01 5.980985e-01 17 17848860 17848949 90 - 0.440 0.605 0.790
ENSG00000175662 E012 59.7272838 0.0009491285 4.466442e-01 6.631694e-01 17 17850893 17850952 60 - 1.673 1.717 0.148
ENSG00000175662 E013 14.9472186 0.0442670255 4.408573e-01 6.593718e-01 17 17850953 17851303 351 - 1.041 1.154 0.407
ENSG00000175662 E014 4.7570491 0.2422137779 5.278465e-01 7.205131e-01 17 17857769 17857855 87 - 0.526 0.743 0.944
ENSG00000175662 E015 61.2496949 0.0012770459 2.004073e-01 4.302481e-01 17 17861476 17861551 76 - 1.770 1.703 -0.224
ENSG00000175662 E016 3.7271660 0.0066027257 5.003155e-01 7.009661e-01 17 17861903 17862427 525 - 0.523 0.642 0.534
ENSG00000175662 E017 78.1397437 0.0006885953 4.789514e-01 6.864130e-01 17 17862731 17862848 118 - 1.848 1.817 -0.105
ENSG00000175662 E018 0.5657866 0.0232720433 2.481754e-01   17 17863274 17863410 137 - 0.336 0.132 -1.717
ENSG00000175662 E019 71.9121942 0.0021781856 7.045407e-01 8.384713e-01 17 17866296 17866419 124 - 1.807 1.788 -0.063
ENSG00000175662 E020 43.9213750 0.0008320386 9.624632e-01 9.831960e-01 17 17866876 17866924 49 - 1.584 1.584 -0.001
ENSG00000175662 E021 3.1364071 0.0077406335 2.498074e-02 1.121650e-01 17 17868965 17869339 375 - 0.797 0.445 -1.560
ENSG00000175662 E022 65.7507246 0.0006224177 2.764948e-02 1.202653e-01 17 17869340 17869473 134 - 1.830 1.724 -0.357
ENSG00000175662 E023 0.1614157 0.0335038579 1.379359e-01   17 17869474 17869914 441 - 0.200 0.000 -10.533
ENSG00000175662 E024 0.0000000       17 17871965 17872064 100 -      
ENSG00000175662 E025 88.7569815 0.0005999453 2.437689e-02 1.102495e-01 17 17879627 17879743 117 - 1.950 1.857 -0.313
ENSG00000175662 E026 87.6019552 0.0008114173 1.158811e-02 6.476218e-02 17 17882705 17882863 159 - 1.959 1.853 -0.354
ENSG00000175662 E027 87.2194487 0.0005983206 2.633174e-04 3.357159e-03 17 17884634 17884768 135 - 1.983 1.832 -0.509
ENSG00000175662 E028 44.0649869 0.0067019753 1.140959e-01 3.059064e-01 17 17893661 17893677 17 - 1.658 1.547 -0.378
ENSG00000175662 E029 92.1458987 0.0025408066 1.217209e-02 6.715803e-02 17 17893678 17893810 133 - 1.978 1.862 -0.391
ENSG00000175662 E030 53.3867724 0.0007865553 4.236103e-01 6.463211e-01 17 17898596 17898613 18 - 1.695 1.653 -0.142
ENSG00000175662 E031 71.7031298 0.0007240459 4.071421e-02 1.565830e-01 17 17898614 17898674 61 - 1.859 1.765 -0.319
ENSG00000175662 E032 77.2779855 0.0005844397 5.655801e-03 3.801944e-02 17 17907447 17907526 80 - 1.915 1.794 -0.408
ENSG00000175662 E033 41.3634579 0.0008898092 1.693154e-02 8.519852e-02 17 17907527 17907531 5 - 1.663 1.521 -0.481
ENSG00000175662 E034 69.2174581 0.0005932472 2.638983e-03 2.120664e-02 17 17972262 17972422 161 - 1.880 1.741 -0.467