ENSG00000175582

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310653 ENSG00000175582 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB6A protein_coding protein_coding 29.81935 15.19397 44.33672 3.291314 1.167158 1.544379 14.27872 9.098489 18.533498 1.550123 1.3955751 1.025630 0.52987917 0.6158000 0.4169000 -0.19890000 5.963325e-02 8.007434e-31 FALSE TRUE
ENST00000336083 ENSG00000175582 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB6A protein_coding protein_coding 29.81935 15.19397 44.33672 3.291314 1.167158 1.544379 10.62885 5.857106 15.633327 1.661144 0.2383061 1.414826 0.35822500 0.3699333 0.3533667 -0.01656667 9.625877e-01 8.007434e-31 FALSE TRUE
ENST00000541973 ENSG00000175582 HEK293_OSMI2_6hA HEK293_TMG_6hB RAB6A protein_coding protein_coding 29.81935 15.19397 44.33672 3.291314 1.167158 1.544379 4.38738 0.000000 9.275733 0.000000 0.3015161 9.858872 0.09714583 0.0000000 0.2093000 0.20930000 8.007434e-31 8.007434e-31 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175582 E001 1094.6255627 0.0055012224 0.0008786221 0.008918704 11 73675638 73677398 1761 - 2.958 3.092 0.446
ENSG00000175582 E002 238.2997526 0.0019884370 0.7711165456 0.879338947 11 73677399 73677590 192 - 2.331 2.369 0.126
ENSG00000175582 E003 296.4863976 0.0044108218 0.0942467068 0.271639288 11 73677591 73677893 303 - 2.443 2.426 -0.057
ENSG00000175582 E004 105.0154226 0.0078573796 0.2107264848 0.442670676 11 73677894 73677907 14 - 1.999 1.978 -0.069
ENSG00000175582 E005 134.5650470 0.0014726975 0.4742781201 0.683039486 11 73677908 73677943 36 - 2.093 2.117 0.080
ENSG00000175582 E006 110.0907926 0.0004418816 0.4725382423 0.681910095 11 73677944 73677962 19 - 2.008 2.032 0.079
ENSG00000175582 E007 152.3300554 0.0013098888 0.1896384245 0.416488408 11 73679654 73679685 32 - 2.151 2.156 0.017
ENSG00000175582 E008 157.0861769 0.0029533527 0.0384698121 0.150786714 11 73679686 73679720 35 - 2.174 2.142 -0.107
ENSG00000175582 E009 0.3641499 0.0316242376 0.5787415933   11 73704164 73704215 52 - 0.083 0.175 1.245
ENSG00000175582 E010 231.7618551 0.0019653417 0.0035710974 0.026769122 11 73707420 73707513 94 - 2.345 2.299 -0.153
ENSG00000175582 E011 233.6919495 0.0014051607 0.0003529279 0.004268287 11 73716251 73716362 112 - 2.352 2.294 -0.195
ENSG00000175582 E012 77.8884980 0.0006732967 0.0983174588 0.278833764 11 73718613 73718718 106 - 1.870 1.848 -0.077
ENSG00000175582 E013 122.8696472 0.0009648034 0.0035087977 0.026398837 11 73718785 73718890 106 - 2.076 2.016 -0.203
ENSG00000175582 E014 144.9951088 0.0147677812 0.1540027830 0.368032075 11 73720846 73720899 54 - 2.146 2.090 -0.189
ENSG00000175582 E015 0.6246688 0.0191701709 0.1705127485   11 73729464 73730764 1301 - 0.264 0.000 -10.303
ENSG00000175582 E016 130.2470086 0.0775181191 0.7349328307 0.857207111 11 73730765 73730823 59 - 2.067 2.114 0.158
ENSG00000175582 E017 0.1308682 0.0326491905 0.2281968406   11 73760048 73760095 48 - 0.000 0.175 10.748
ENSG00000175582 E018 196.5287575 1.5662922420 0.5249021069 0.718428480 11 73760566 73761137 572 - 2.187 2.390 0.677