ENSG00000175581

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310614 ENSG00000175581 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL48 protein_coding protein_coding 45.6801 33.55268 55.01847 3.789456 1.879849 0.7133205 30.997740 23.44936 31.54176 2.690781 1.776327 0.427557 0.68081250 0.69870000 0.5725000 -0.1262 0.0345761 0.0345761 FALSE TRUE
ENST00000537007 ENSG00000175581 HEK293_OSMI2_6hA HEK293_TMG_6hB MRPL48 protein_coding protein_coding 45.6801 33.55268 55.01847 3.789456 1.879849 0.7133205 4.585498 1.78066 12.36069 1.025581 1.085411 2.788362 0.09517083 0.05303333 0.2239333 0.1709 0.5292426 0.0345761 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175581 E001 1.2780819 0.0136968632 0.872296380   11 73787242 73787558 317 + 0.344 0.376 0.187
ENSG00000175581 E002 6.2623743 0.0406482072 0.934870971 0.96964216 11 73787559 73787871 313 + 0.866 0.856 -0.038
ENSG00000175581 E003 5.7779236 0.0458571738 0.387924288 0.61886770 11 73787872 73787873 2 + 0.764 0.898 0.524
ENSG00000175581 E004 6.4509255 0.0242180123 0.377897249 0.61046680 11 73787874 73787876 3 + 0.808 0.934 0.484
ENSG00000175581 E005 15.6364612 0.0020739156 0.354178722 0.59099272 11 73787877 73787882 6 + 1.253 1.180 -0.261
ENSG00000175581 E006 18.7895564 0.0017081971 0.839403606 0.91904323 11 73787883 73787884 2 + 1.302 1.292 -0.035
ENSG00000175581 E007 32.1036988 0.0011113913 0.030392508 0.12852766 11 73787885 73787890 6 + 1.578 1.450 -0.440
ENSG00000175581 E008 43.3773459 0.0009086341 0.020269101 0.09681770 11 73787891 73787894 4 + 1.704 1.585 -0.403
ENSG00000175581 E009 63.6292089 0.0026881942 0.535400732 0.72588459 11 73787895 73787905 11 + 1.827 1.804 -0.077
ENSG00000175581 E010 79.1063024 0.0008013642 0.923178460 0.96386769 11 73787906 73787908 3 + 1.907 1.909 0.007
ENSG00000175581 E011 122.3591697 0.0014433169 0.601049951 0.77087291 11 73787909 73787929 21 + 2.081 2.106 0.084
ENSG00000175581 E012 154.6333520 0.0054823705 0.652820085 0.80526363 11 73787930 73787956 27 + 2.182 2.207 0.085
ENSG00000175581 E013 189.3680469 0.0033898336 0.876817143 0.93960859 11 73787957 73787992 36 + 2.276 2.288 0.039
ENSG00000175581 E014 8.3499669 0.0248969166 0.915287415 0.95980152 11 73789335 73789490 156 + 0.950 0.969 0.072
ENSG00000175581 E015 0.0000000       11 73802081 73802177 97 +      
ENSG00000175581 E016 195.8744443 0.0029840221 0.610601956 0.77734157 11 73805027 73805079 53 + 2.303 2.288 -0.049
ENSG00000175581 E017 0.8214337 0.0177527319 0.023676075   11 73808308 73808312 5 + 0.400 0.001 -10.313
ENSG00000175581 E018 176.8760492 0.0002769825 0.109375510 0.29809159 11 73808313 73808350 38 + 2.268 2.231 -0.122
ENSG00000175581 E019 5.5344885 0.0678170960 0.513603084 0.71067833 11 73817823 73817824 2 + 0.847 0.747 -0.396
ENSG00000175581 E020 17.3080483 0.0313765668 0.949613247 0.97686158 11 73817825 73817947 123 + 1.260 1.252 -0.028
ENSG00000175581 E021 6.5048262 0.0118480658 0.589423178 0.76329982 11 73823013 73823070 58 + 0.901 0.836 -0.250
ENSG00000175581 E022 345.4984686 0.0002072654 0.031475501 0.13170541 11 73825708 73825796 89 + 2.557 2.523 -0.115
ENSG00000175581 E023 4.1312246 0.1277581123 0.085609063 0.25569895 11 73842113 73843246 1134 + 0.491 0.853 1.546
ENSG00000175581 E024 10.6387441 0.0034831750 0.005846009 0.03898632 11 73843247 73843367 121 + 0.900 1.190 1.058
ENSG00000175581 E025 521.0447123 0.0001558119 0.149166145 0.36102731 11 73844807 73844976 170 + 2.724 2.709 -0.052
ENSG00000175581 E026 5.2131297 0.0073301021 0.424562542 0.64696025 11 73844977 73845137 161 + 0.743 0.856 0.446
ENSG00000175581 E027 352.7826307 0.0004095736 0.114992004 0.30746913 11 73859907 73860009 103 + 2.530 2.567 0.123
ENSG00000175581 E028 1.4631504 0.0277621501 0.875021736 0.93872169 11 73860010 73860480 471 + 0.399 0.433 0.181
ENSG00000175581 E029 382.9102129 0.0038948227 0.199688824 0.42926816 11 73863172 73863261 90 + 2.560 2.607 0.157
ENSG00000175581 E030 486.9983707 0.0019407022 0.281156341 0.52142989 11 73864296 73865133 838 + 2.672 2.704 0.105