ENSG00000175455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000409657 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding nonsense_mediated_decay 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 2.0775495 2.8984884 2.3025624 0.21636012 0.3654825 -0.3307773 0.19426667 0.30170000 0.11370000 -0.18800000 0.001171047 0.001171047 FALSE TRUE
ENST00000409697 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding protein_coding 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 1.6366637 0.5314601 1.7175321 0.33347528 0.6095273 1.6737856 0.12691667 0.05920000 0.08706667 0.02786667 0.864826515 0.001171047 FALSE TRUE
ENST00000419247 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding protein_coding 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.8004182 0.5349856 0.9300533 0.11178063 0.1100217 0.7865245 0.05458750 0.05736667 0.04590000 -0.01146667 0.923585206 0.001171047 FALSE TRUE
ENST00000426152 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding protein_coding 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.9846363 0.3014069 1.2608678 0.30140695 0.5018178 2.0289409 0.05890417 0.04080000 0.06180000 0.02100000 0.507814888 0.001171047 FALSE FALSE
ENST00000485727 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding protein_coding 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.9199110 0.2440644 1.7559694 0.08900065 0.0876665 2.7971942 0.05259583 0.02320000 0.08670000 0.06350000 0.001671068 0.001171047 FALSE TRUE
ENST00000488653 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding protein_coding 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.8228055 0.8093356 0.6568108 0.39045398 0.6568108 -0.2971770 0.07594167 0.07810000 0.03180000 -0.04630000 0.389462407 0.001171047 FALSE TRUE
ENST00000495381 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding retained_intron 14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 1.0896251 1.1736714 1.9405746 0.25635093 0.1810953 0.7206305 0.08156667 0.11790000 0.09556667 -0.02233333 0.778949548 0.001171047 FALSE TRUE
MSTRG.23546.10 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding   14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.2999247 0.0000000 1.1449463 0.00000000 0.5007848 6.8516819 0.01648750 0.00000000 0.05496667 0.05496667 0.017914990 0.001171047 FALSE TRUE
MSTRG.23546.19 ENSG00000175455 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC14 protein_coding   14.02001 9.80103 20.24469 1.390098 0.6737819 1.04578 0.6516718 0.0532889 1.3861647 0.05328890 0.3775085 4.4633729 0.03440417 0.00720000 0.06876667 0.06156667 0.096737996 0.001171047 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175455 E001 2.7602304 0.008463056 4.127981e-03 2.988269e-02 3 123897305 123897510 206 - 0.298 0.813 2.482
ENSG00000175455 E002 3.0207493 0.008582445 6.510230e-02 2.141324e-01 3 123897511 123897613 103 - 0.435 0.783 1.559
ENSG00000175455 E003 0.0000000       3 123913422 123913452 31 -      
ENSG00000175455 E004 5.3767061 0.035144008 4.265742e-01 6.484928e-01 3 123913453 123913716 264 - 0.732 0.911 0.702
ENSG00000175455 E005 4.7390534 0.042472931 4.856176e-01 6.909927e-01 3 123913717 123913724 8 - 0.690 0.863 0.690
ENSG00000175455 E006 5.0509261 0.103077115 8.385061e-01 9.185758e-01 3 123913725 123913726 2 - 0.748 0.834 0.338
ENSG00000175455 E007 111.9587267 1.161511661 3.409451e-01 5.788965e-01 3 123913727 123914318 592 - 1.880 2.219 1.137
ENSG00000175455 E008 40.5692937 0.599430927 2.889906e-01 5.295463e-01 3 123914319 123914393 75 - 1.489 1.750 0.889
ENSG00000175455 E009 85.6379005 0.804068535 2.435323e-01 4.805479e-01 3 123914394 123914661 268 - 1.752 2.113 1.216
ENSG00000175455 E010 90.7449733 0.830379039 2.527731e-01 4.909498e-01 3 123914662 123914879 218 - 1.783 2.134 1.179
ENSG00000175455 E011 77.9858171 0.808610889 3.078079e-01 5.484279e-01 3 123914880 123914994 115 - 1.752 2.042 0.976
ENSG00000175455 E012 74.9666550 0.794814672 3.143161e-01 5.545393e-01 3 123914995 123915132 138 - 1.737 2.023 0.964
ENSG00000175455 E013 49.2480801 0.685154055 3.716481e-01 6.053245e-01 3 123915133 123915198 66 - 1.595 1.808 0.721
ENSG00000175455 E014 29.8203737 0.502664299 3.284884e-01 5.674963e-01 3 123915199 123915199 1 - 1.375 1.606 0.793
ENSG00000175455 E015 60.7977990 0.735914415 3.375163e-01 5.758985e-01 3 123915200 123915289 90 - 1.655 1.927 0.918
ENSG00000175455 E016 51.3965206 0.684814165 3.349186e-01 5.734887e-01 3 123915290 123915372 83 - 1.587 1.852 0.898
ENSG00000175455 E017 37.5933303 0.600121692 3.829756e-01 6.147193e-01 3 123915373 123915399 27 - 1.490 1.684 0.662
ENSG00000175455 E018 30.2999667 0.529384919 3.647628e-01 5.997170e-01 3 123915400 123915400 1 - 1.400 1.594 0.666
ENSG00000175455 E019 46.4776645 0.670742791 3.728513e-01 6.063620e-01 3 123915401 123915471 71 - 1.575 1.779 0.694
ENSG00000175455 E020 30.5811279 0.524170606 3.466923e-01 5.842760e-01 3 123915472 123915481 10 - 1.396 1.605 0.716
ENSG00000175455 E021 87.4462462 0.872727555 4.098622e-01 6.358856e-01 3 123915482 123915718 237 - 1.835 2.059 0.753
ENSG00000175455 E022 0.6544085 0.019207385 5.046505e-01   3 123930772 123931101 330 - 0.240 0.153 -0.804
ENSG00000175455 E023 73.5095174 0.016465705 2.347151e-01 4.705165e-01 3 123931102 123931234 133 - 1.789 1.962 0.582
ENSG00000175455 E024 83.4457439 0.003886585 5.492183e-01 7.357933e-01 3 123931308 123931526 219 - 1.893 1.956 0.211
ENSG00000175455 E025 1.1774014 0.178971459 2.632783e-02   3 123933525 123933526 2 - 0.440 0.000 -10.785
ENSG00000175455 E026 6.9297821 0.049749838 8.193413e-01 9.076990e-01 3 123933527 123933672 146 - 0.871 0.911 0.154
ENSG00000175455 E027 78.2239398 0.006495178 2.400401e-02 1.090977e-01 3 123933673 123933755 83 - 1.900 1.862 -0.126
ENSG00000175455 E028 97.2861273 0.024388742 1.782085e-01 4.014899e-01 3 123944849 123944990 142 - 1.987 1.966 -0.070
ENSG00000175455 E029 31.0095695 0.041350947 6.820939e-01 8.240161e-01 3 123946803 123946803 1 - 1.476 1.515 0.133
ENSG00000175455 E030 90.4547227 0.035267654 4.171090e-01 6.414851e-01 3 123946804 123947012 209 - 1.945 1.952 0.023
ENSG00000175455 E031 53.5207193 0.038956094 1.925340e-01 4.201689e-01 3 123947013 123947057 45 - 1.741 1.691 -0.170
ENSG00000175455 E032 72.5542024 0.011863425 1.588465e-01 3.750283e-01 3 123947058 123947195 138 - 1.854 1.852 -0.008
ENSG00000175455 E033 49.1259475 0.014526741 1.454996e-01 3.556442e-01 3 123947196 123947279 84 - 1.693 1.682 -0.037
ENSG00000175455 E034 39.4565117 0.016306132 5.278876e-01 7.205345e-01 3 123947280 123947300 21 - 1.579 1.621 0.145
ENSG00000175455 E035 38.3218047 0.005196928 4.871636e-01 6.920067e-01 3 123947301 123947319 19 - 1.569 1.610 0.139
ENSG00000175455 E036 52.5323621 0.019447447 1.445029e-01 3.541675e-01 3 123948691 123948707 17 - 1.724 1.697 -0.093
ENSG00000175455 E037 81.7840919 0.009808047 1.378158e-01 3.441605e-01 3 123948708 123948785 78 - 1.905 1.904 -0.004
ENSG00000175455 E038 66.7844251 0.008582900 2.663828e-01 5.058870e-01 3 123948896 123948945 50 - 1.810 1.835 0.084
ENSG00000175455 E039 102.8407804 0.014517950 3.322769e-01 5.710785e-01 3 123948946 123949132 187 - 1.994 2.017 0.078
ENSG00000175455 E040 9.4246650 0.139520234 8.853030e-01 9.441145e-01 3 123949133 123949313 181 - 0.990 1.026 0.131
ENSG00000175455 E041 19.1752130 0.034352360 7.273646e-02 2.302605e-01 3 123949384 123949464 81 - 1.334 1.200 -0.470
ENSG00000175455 E042 19.8725170 0.077517263 2.760021e-02 1.201153e-01 3 123949465 123949586 122 - 1.386 1.112 -0.963
ENSG00000175455 E043 95.9242415 0.043672723 1.002770e-07 3.715762e-06 3 123952595 123955842 3248 - 2.098 1.617 -1.622
ENSG00000175455 E044 59.3649690 0.022694843 2.110351e-01 4.429990e-01 3 123955843 123955965 123 - 1.774 1.755 -0.065
ENSG00000175455 E045 22.6680273 0.044306261 3.359943e-01 5.744358e-01 3 123955966 123956045 80 - 1.370 1.340 -0.102
ENSG00000175455 E046 32.2788489 0.050999407 4.382672e-01 6.574402e-01 3 123956046 123956076 31 - 1.515 1.493 -0.078
ENSG00000175455 E047 33.6751407 0.032294453 1.646750e-01 3.835948e-01 3 123956077 123956115 39 - 1.549 1.481 -0.230
ENSG00000175455 E048 24.5537746 0.076983275 3.015761e-01 5.420906e-01 3 123956116 123956354 239 - 1.416 1.348 -0.235
ENSG00000175455 E049 38.8324045 0.019335648 6.186676e-02 2.070267e-01 3 123956355 123956427 73 - 1.614 1.537 -0.261
ENSG00000175455 E050 41.3594624 0.099679520 2.648986e-01 5.042186e-01 3 123956428 123956739 312 - 1.621 1.599 -0.073
ENSG00000175455 E051 42.3746819 0.027306021 7.084663e-02 2.264108e-01 3 123956740 123956795 56 - 1.648 1.582 -0.222
ENSG00000175455 E052 31.8002827 0.174747576 2.791688e-03 2.213525e-02 3 123956796 123958900 2105 - 1.622 1.173 -1.558
ENSG00000175455 E053 38.3876614 0.024259011 8.247592e-02 2.496757e-01 3 123961144 123961408 265 - 1.600 1.552 -0.162