ENSG00000175274

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000395648 ENSG00000175274 HEK293_OSMI2_6hA HEK293_TMG_6hB TP53I11 protein_coding protein_coding 19.8103 30.34512 8.249409 4.504086 0.7988513 -1.87783 10.300089 15.472202 4.0816191 2.4101742 0.3578344 -1.919867 0.51210833 0.50970000 0.50033333 -0.009366667 9.995483e-01 1.151239e-11 FALSE TRUE
ENST00000531130 ENSG00000175274 HEK293_OSMI2_6hA HEK293_TMG_6hB TP53I11 protein_coding processed_transcript 19.8103 30.34512 8.249409 4.504086 0.7988513 -1.87783 1.742767 4.673705 0.0000000 1.2806667 0.0000000 -8.871506 0.06999583 0.14780000 0.00000000 -0.147800000 1.151239e-11 1.151239e-11 FALSE TRUE
ENST00000531928 ENSG00000175274 HEK293_OSMI2_6hA HEK293_TMG_6hB TP53I11 protein_coding protein_coding 19.8103 30.34512 8.249409 4.504086 0.7988513 -1.87783 1.629528 2.293214 0.9192046 0.5312633 0.3029124 -1.309580 0.08090417 0.07456667 0.10760000 0.033033333 8.077697e-01 1.151239e-11 FALSE TRUE
ENST00000532253 ENSG00000175274 HEK293_OSMI2_6hA HEK293_TMG_6hB TP53I11 protein_coding nonsense_mediated_decay 19.8103 30.34512 8.249409 4.504086 0.7988513 -1.87783 1.053401 1.535303 0.6895065 0.5164065 0.1626219 -1.143480 0.06577500 0.05840000 0.08186667 0.023466667 7.869909e-01 1.151239e-11 FALSE TRUE
ENST00000616990 ENSG00000175274 HEK293_OSMI2_6hA HEK293_TMG_6hB TP53I11 protein_coding protein_coding 19.8103 30.34512 8.249409 4.504086 0.7988513 -1.87783 1.779794 3.068307 0.9048296 0.8000453 0.3783442 -1.750562 0.09045833 0.09763333 0.10806667 0.010433333 1.000000e+00 1.151239e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175274 E001 0.0000000       11 44885903 44886564 662 -      
ENSG00000175274 E002 0.1308682 0.0326491905 1.000000e+00   11 44901220 44901318 99 - 0.000 0.062 7.820
ENSG00000175274 E003 0.3032425 0.0274424043 1.000000e+00   11 44903356 44903659 304 - 0.000 0.116 10.835
ENSG00000175274 E004 0.1308682 0.0326491905 1.000000e+00   11 44903780 44903890 111 - 0.000 0.062 9.795
ENSG00000175274 E005 2.5593337 0.0090130661 5.134045e-01 7.105141e-01 11 44932348 44932355 8 - 0.371 0.499 0.671
ENSG00000175274 E006 504.0738832 0.0011823147 9.935191e-03 5.787281e-02 11 44932356 44933482 1127 - 2.550 2.606 0.188
ENSG00000175274 E007 232.5158040 0.0020433315 1.609632e-01 3.782326e-01 11 44933483 44933865 383 - 2.304 2.248 -0.185
ENSG00000175274 E008 521.4779425 0.0023969964 9.782232e-02 2.779680e-01 11 44933866 44934947 1082 - 2.649 2.597 -0.175
ENSG00000175274 E009 67.0188489 0.0006221090 4.714065e-02 1.728604e-01 11 44934948 44934979 32 - 1.633 1.745 0.380
ENSG00000175274 E010 71.3361892 0.0005298671 5.394349e-01 7.285662e-01 11 44934980 44935017 38 - 1.730 1.761 0.104
ENSG00000175274 E011 53.3490996 0.0006822028 9.554294e-01 9.795916e-01 11 44935561 44935567 7 - 1.633 1.634 0.006
ENSG00000175274 E012 60.9171405 0.0006934524 8.270144e-01 9.121059e-01 11 44935568 44935577 10 - 1.702 1.688 -0.048
ENSG00000175274 E013 73.0701971 0.0005377697 8.785851e-01 9.405695e-01 11 44935578 44935619 42 - 1.762 1.768 0.020
ENSG00000175274 E014 80.2163134 0.0004851279 9.599842e-01 9.818470e-01 11 44935620 44935662 43 - 1.805 1.806 0.002
ENSG00000175274 E015 9.2125963 0.1112241583 5.898329e-01 7.636033e-01 11 44935663 44936056 394 - 0.990 0.890 -0.377
ENSG00000175274 E016 13.9780714 0.0027273385 7.357528e-01 8.577805e-01 11 44936218 44936373 156 - 1.047 1.082 0.127
ENSG00000175274 E017 15.8981013 0.0069042019 9.024413e-01 9.530787e-01 11 44936374 44936455 82 - 1.119 1.128 0.034
ENSG00000175274 E018 22.3112405 0.0229318088 5.012430e-01 7.016802e-01 11 44936456 44936558 103 - 1.326 1.246 -0.282
ENSG00000175274 E019 25.4692051 0.0089206299 9.813643e-02 2.785157e-01 11 44936559 44936667 109 - 1.437 1.282 -0.537
ENSG00000175274 E020 16.5319109 0.0021963852 2.352221e-02 1.076193e-01 11 44936668 44936689 22 - 1.314 1.098 -0.767
ENSG00000175274 E021 2.1055346 0.1468135458 1.670470e-01 3.865961e-01 11 44936690 44936802 113 - 0.648 0.344 -1.510
ENSG00000175274 E022 68.7101833 0.0005904761 7.047675e-01 8.385758e-01 11 44936803 44936803 1 - 1.757 1.735 -0.074
ENSG00000175274 E023 87.0350552 0.0006281912 8.031624e-01 8.981658e-01 11 44936804 44936842 39 - 1.853 1.840 -0.045
ENSG00000175274 E024 64.4414016 0.0006150413 3.982844e-01 6.268916e-01 11 44936843 44936849 7 - 1.752 1.704 -0.160
ENSG00000175274 E025 62.2758349 0.0007329465 6.211084e-01 7.845991e-01 11 44936850 44936856 7 - 1.725 1.696 -0.097
ENSG00000175274 E026 63.7135495 0.0012684636 5.136363e-01 7.107017e-01 11 44936857 44936879 23 - 1.741 1.704 -0.124
ENSG00000175274 E027 51.4812999 0.0009035989 1.203949e-01 3.164612e-01 11 44936880 44936882 3 - 1.696 1.603 -0.315
ENSG00000175274 E028 60.4698931 0.0006780120 1.583949e-01 3.743786e-01 11 44936883 44936899 17 - 1.752 1.673 -0.267
ENSG00000175274 E029 3.1353593 0.1452266510 1.616186e-01 3.791526e-01 11 44936900 44937108 209 - 0.765 0.468 -1.318
ENSG00000175274 E030 2.4348829 0.0088457135 1.829748e-01 4.078133e-01 11 44937109 44937303 195 - 0.642 0.405 -1.135
ENSG00000175274 E031 64.6688363 0.0007843110 6.078518e-01 7.754315e-01 11 44937304 44937320 17 - 1.741 1.712 -0.099
ENSG00000175274 E032 66.1353992 0.0007673853 7.461538e-01 8.644646e-01 11 44937321 44937352 32 - 1.741 1.722 -0.064
ENSG00000175274 E033 82.9111987 0.0008045353 1.651087e-01 3.840942e-01 11 44937555 44937613 59 - 1.762 1.831 0.234
ENSG00000175274 E034 117.6941258 0.0003804340 3.876050e-03 2.845715e-02 11 44938207 44938366 160 - 1.865 1.989 0.415
ENSG00000175274 E035 0.7502172 0.2215776702 4.783985e-01   11 44938367 44938417 51 - 0.000 0.214 11.198
ENSG00000175274 E036 1.2546191 0.2901355178 4.330249e-01   11 44939114 44939165 52 - 0.474 0.272 -1.185
ENSG00000175274 E037 8.3446087 0.0040818491 9.207235e-01 9.625855e-01 11 44939166 44939190 25 - 0.890 0.873 -0.065
ENSG00000175274 E038 8.2005461 0.0057542888 1.906079e-01 4.176752e-01 11 44939191 44939281 91 - 0.704 0.899 0.771
ENSG00000175274 E039 1.3438382 0.1351365756 1.559015e-01   11 44940514 44940747 234 - 0.000 0.372 12.429
ENSG00000175274 E040 2.3491524 0.3402207721 8.306950e-01 9.141763e-01 11 44941003 44941077 75 - 0.476 0.451 -0.130
ENSG00000175274 E041 0.3447487 0.6174596246 1.000000e+00   11 44943152 44943191 40 - 0.000 0.119 9.862
ENSG00000175274 E042 0.4341107 0.0244411696 6.880871e-01   11 44947039 44947253 215 - 0.000 0.164 11.438
ENSG00000175274 E043 0.8934196 0.1794465451 1.009939e-01   11 44949973 44950208 236 - 0.484 0.161 -2.193
ENSG00000175274 E044 44.8896956 0.0008525373 2.546937e-06 6.441227e-05 11 44950677 44950876 200 - 1.236 1.609 1.288
ENSG00000175274 E045 11.7534603 0.0047267254 8.033174e-01 8.982540e-01 11 44950877 44951306 430 - 0.991 1.021 0.113