ENSG00000175198

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000376279 ENSG00000175198 HEK293_OSMI2_6hA HEK293_TMG_6hB PCCA protein_coding protein_coding 7.42189 3.88559 12.77538 0.4973837 0.2329067 1.714581 0.45237756 0.2825023 0.3946366 0.1538214 0.3946366 0.4681786 0.05399167 0.07653333 0.03146667 -0.04506667 6.476456e-01 6.807457e-08 FALSE TRUE
ENST00000376285 ENSG00000175198 HEK293_OSMI2_6hA HEK293_TMG_6hB PCCA protein_coding protein_coding 7.42189 3.88559 12.77538 0.4973837 0.2329067 1.714581 5.10621506 2.5191604 8.6694305 0.8290199 0.4199443 1.7789418 0.67378750 0.60876667 0.67943333 0.07066667 9.556505e-01 6.807457e-08 FALSE TRUE
ENST00000424527 ENSG00000175198 HEK293_OSMI2_6hA HEK293_TMG_6hB PCCA protein_coding protein_coding 7.42189 3.88559 12.77538 0.4973837 0.2329067 1.714581 0.09035114 0.0000000 0.7228091 0.0000000 0.7228091 6.1953656 0.00682500 0.00000000 0.05460000 0.05460000 1.000000e+00 6.807457e-08 FALSE FALSE
ENST00000458283 ENSG00000175198 HEK293_OSMI2_6hA HEK293_TMG_6hB PCCA protein_coding protein_coding 7.42189 3.88559 12.77538 0.4973837 0.2329067 1.714581 0.60985898 0.0000000 1.9813986 0.0000000 0.3351207 7.6376382 0.08402917 0.00000000 0.15506667 0.15506667 6.807457e-08 6.807457e-08 FALSE TRUE
ENST00000637657 ENSG00000175198 HEK293_OSMI2_6hA HEK293_TMG_6hB PCCA protein_coding protein_coding 7.42189 3.88559 12.77538 0.4973837 0.2329067 1.714581 0.04737806 0.3299488 0.0000000 0.3299488 0.0000000 -5.0872455 0.01477083 0.11410000 0.00000000 -0.11410000 7.796678e-01 6.807457e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175198 E001 0.9006742 0.2723583816 0.222371576   13 100089015 100089092 78 + 0.153 0.404 1.859
ENSG00000175198 E002 0.9006742 0.2723583816 0.222371576   13 100089093 100089099 7 + 0.153 0.404 1.859
ENSG00000175198 E003 11.4370702 0.0027536583 0.018421021 0.09043458 13 100089100 100089225 126 + 0.975 1.212 0.855
ENSG00000175198 E004 9.3040950 0.0037759100 0.377363935 0.61015676 13 100102883 100102898 16 + 0.955 1.055 0.367
ENSG00000175198 E005 18.3566723 0.0039643095 0.383032570 0.61476721 13 100102899 100102960 62 + 1.231 1.306 0.263
ENSG00000175198 E006 0.0000000       13 100104464 100104560 97 +      
ENSG00000175198 E007 23.8690866 0.0073255199 0.531122864 0.72286192 13 100111841 100111888 48 + 1.351 1.400 0.169
ENSG00000175198 E008 31.0148376 0.0078999023 0.612571591 0.77862331 13 100111993 100112061 69 + 1.489 1.448 -0.143
ENSG00000175198 E009 0.3228314 0.4180181943 0.693269328   13 100149201 100149705 505 + 0.154 0.000 -10.661
ENSG00000175198 E010 0.1426347 0.0322569848 1.000000000   13 100154494 100154656 163 + 0.083 0.000 -9.653
ENSG00000175198 E011 39.3331430 0.0009140560 0.312183030 0.55250752 13 100154979 100155092 114 + 1.591 1.531 -0.204
ENSG00000175198 E012 33.3508210 0.0010726962 0.496276071 0.69838570 13 100157287 100157340 54 + 1.514 1.471 -0.148
ENSG00000175198 E013 0.8344176 0.0190341009 0.644981638   13 100160673 100161625 953 + 0.213 0.298 0.636
ENSG00000175198 E014 51.4680648 0.0007222409 0.581204670 0.75793374 13 100209332 100209463 132 + 1.693 1.666 -0.094
ENSG00000175198 E015 33.8563601 0.0015667408 0.646118144 0.80092436 13 100235842 100235878 37 + 1.515 1.485 -0.101
ENSG00000175198 E016 4.3768407 0.0489935241 0.010643449 0.06087097 13 100236481 100237497 1017 + 0.521 0.930 1.695
ENSG00000175198 E017 42.0322055 0.0029965996 0.965087491 0.98447340 13 100257595 100257673 79 + 1.597 1.601 0.014
ENSG00000175198 E018 39.5788272 0.0042580126 0.109492460 0.29823472 13 100262729 100262831 103 + 1.537 1.642 0.356
ENSG00000175198 E019 41.1272952 0.0099057644 0.221335019 0.45509826 13 100268689 100268783 95 + 1.563 1.656 0.317
ENSG00000175198 E020 49.0334762 0.0024945761 0.937376209 0.97088966 13 100273196 100273346 151 + 1.669 1.669 0.000
ENSG00000175198 E021 0.0000000       13 100293224 100293254 31 +      
ENSG00000175198 E022 50.0512048 0.0211258947 0.032061193 0.13340017 13 100301460 100301603 144 + 1.718 1.547 -0.582
ENSG00000175198 E023 34.9121378 0.0011969971 0.069523375 0.22382309 13 100302924 100302996 73 + 1.557 1.441 -0.399
ENSG00000175198 E024 21.2259505 0.0017086213 0.076776073 0.23832608 13 100302997 100302998 2 + 1.357 1.211 -0.511
ENSG00000175198 E025 0.7673035 0.0172671820 0.124294859   13 100305776 100305834 59 + 0.313 0.000 -11.975
ENSG00000175198 E026 35.6351678 0.0010843486 0.381352277 0.61336388 13 100307192 100307260 69 + 1.547 1.492 -0.186
ENSG00000175198 E027 39.3471367 0.0010853597 0.176970139 0.39969677 13 100309833 100309908 76 + 1.594 1.512 -0.278
ENSG00000175198 E028 47.4388502 0.0087883676 0.650086157 0.80361908 13 100330561 100330671 111 + 1.657 1.627 -0.103
ENSG00000175198 E029 0.2027342 0.0347521649 0.204281967   13 100330672 100330672 1 + 0.000 0.174 12.068
ENSG00000175198 E030 51.5579685 0.0164792608 0.339254503 0.57733881 13 100340157 100340259 103 + 1.706 1.625 -0.277
ENSG00000175198 E031 34.9484528 0.0013615620 0.070457993 0.22563712 13 100368472 100368498 27 + 1.552 1.433 -0.408
ENSG00000175198 E032 45.9707817 0.0007746237 0.228005381 0.46296520 13 100368499 100368574 76 + 1.657 1.590 -0.226
ENSG00000175198 E033 50.0297329 0.0007683942 0.975159495 0.98945158 13 100425633 100425731 99 + 1.675 1.675 0.001
ENSG00000175198 E034 40.1914124 0.0010272788 0.514848012 0.71153764 13 100449252 100449305 54 + 1.572 1.611 0.135
ENSG00000175198 E035 0.8624920 0.3637262687 0.067785318   13 100489968 100491649 1682 + 0.082 0.484 3.294
ENSG00000175198 E036 0.5530924 0.0294954043 0.195462136   13 100491650 100491817 168 + 0.083 0.299 2.225
ENSG00000175198 E037 48.3414431 0.0008816896 0.001340525 0.01246520 13 100515427 100515567 141 + 1.605 1.772 0.565
ENSG00000175198 E038 1.4168247 0.6003373532 0.639111724 0.79631301 13 100527297 100527344 48 + 0.261 0.503 1.406
ENSG00000175198 E039 41.7499287 0.0018498793 0.063054358 0.20954737 13 100527675 100527752 78 + 1.567 1.674 0.367
ENSG00000175198 E040 47.6319461 0.0934902329 0.314163653 0.55439559 13 100530098 100530437 340 + 1.617 1.727 0.373