ENSG00000175155

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312655 ENSG00000175155 HEK293_OSMI2_6hA HEK293_TMG_6hB YPEL2 protein_coding protein_coding 1.418082 0.6614156 2.733295 0.04460056 0.1378099 2.030632 0.93212352 0.6614156 1.6911194 0.04460056 0.4804493 1.341206 0.62049167 1 0.6284333 -0.3715667 0.040439956 0.003105596 FALSE FALSE
ENST00000581865 ENSG00000175155 HEK293_OSMI2_6hA HEK293_TMG_6hB YPEL2 protein_coding processed_transcript 1.418082 0.6614156 2.733295 0.04460056 0.1378099 2.030632 0.18647227 0.0000000 0.6008099 0.00000000 0.1171773 5.932651 0.15000833 0 0.2201333 0.2201333 0.003105596 0.003105596   FALSE
ENST00000585166 ENSG00000175155 HEK293_OSMI2_6hA HEK293_TMG_6hB YPEL2 protein_coding protein_coding 1.418082 0.6614156 2.733295 0.04460056 0.1378099 2.030632 0.04383912 0.0000000 0.0000000 0.00000000 0.0000000 0.000000 0.05420833 0 0.0000000 0.0000000   0.003105596 FALSE FALSE
ENST00000672916 ENSG00000175155 HEK293_OSMI2_6hA HEK293_TMG_6hB YPEL2 protein_coding protein_coding 1.418082 0.6614156 2.733295 0.04460056 0.1378099 2.030632 0.25523787 0.0000000 0.4413660 0.00000000 0.4413660 5.496226 0.17472500 0 0.1514000 0.1514000 1.000000000 0.003105596 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175155 E001 0.5657866 0.022890304 0.25648066   17 59331655 59331688 34 + 0.133 0.333 1.682
ENSG00000175155 E002 1.6554033 0.011293907 0.01497026 0.07797015 17 59331689 59331720 32 + 0.235 0.651 2.272
ENSG00000175155 E003 3.2599008 0.007483470 0.10614947 0.29261620 17 59331721 59331824 104 + 0.500 0.751 1.100
ENSG00000175155 E004 0.0000000       17 59345156 59345295 140 +      
ENSG00000175155 E005 5.2881208 0.006265636 0.91678109 0.96054857 17 59353215 59353310 96 + 0.740 0.751 0.043
ENSG00000175155 E006 10.1176881 0.008014504 0.76789323 0.87735093 17 59353311 59353526 216 + 0.999 0.959 -0.151
ENSG00000175155 E007 0.0000000       17 59353527 59356303 2777 +      
ENSG00000175155 E008 6.8449054 0.037851956 0.33136366 0.57023601 17 59388327 59388370 44 + 0.872 0.704 -0.669
ENSG00000175155 E009 0.1426347 0.031488941 1.00000000   17 59388840 59389359 520 + 0.072 0.001 -6.622
ENSG00000175155 E010 9.7636908 0.003382559 0.29847684 0.53892163 17 59389360 59389468 109 + 1.000 0.867 -0.499
ENSG00000175155 E011 191.1405337 0.014354324 0.93337048 0.96882656 17 59397101 59401729 4629 + 2.216 2.215 -0.006