ENSG00000175115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320580 ENSG00000175115 HEK293_OSMI2_6hA HEK293_TMG_6hB PACS1 protein_coding protein_coding 11.00672 17.09433 6.312557 3.638761 0.1961228 -1.435781 7.8039263 12.4781445 4.88447292 2.9492189 0.37331859 -1.3513337 0.74424583 0.71953333 0.77356667 0.05403333 8.266929e-01 4.423863e-08 FALSE TRUE
ENST00000529677 ENSG00000175115 HEK293_OSMI2_6hA HEK293_TMG_6hB PACS1 protein_coding protein_coding 11.00672 17.09433 6.312557 3.638761 0.1961228 -1.435781 1.2126209 1.2641934 0.09792137 0.5544799 0.05780417 -3.5615318 0.07695833 0.06403333 0.01523333 -0.04880000 4.684526e-01 4.423863e-08 FALSE TRUE
ENST00000529757 ENSG00000175115 HEK293_OSMI2_6hA HEK293_TMG_6hB PACS1 protein_coding protein_coding 11.00672 17.09433 6.312557 3.638761 0.1961228 -1.435781 0.9657539 2.3149804 0.00000000 0.5968890 0.00000000 -7.8610747 0.06505833 0.14150000 0.00000000 -0.14150000 4.423863e-08 4.423863e-08 FALSE TRUE
ENST00000533811 ENSG00000175115 HEK293_OSMI2_6hA HEK293_TMG_6hB PACS1 protein_coding retained_intron 11.00672 17.09433 6.312557 3.638761 0.1961228 -1.435781 0.2426915 0.2536472 0.46531930 0.1677775 0.10989568 0.8502885 0.03045417 0.02216667 0.07493333 0.05276667 4.193222e-01 4.423863e-08   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000175115 E001 0.8148287 0.0171516190 0.9073691107   11 66070272 66070362 91 + 0.202 0.231 0.248
ENSG00000175115 E002 45.2735509 0.0088333662 0.5990935725 0.769607992 11 66070363 66070842 480 + 1.550 1.600 0.170
ENSG00000175115 E003 0.1723744 0.0643630036 1.0000000000   11 66083973 66084230 258 + 0.000 0.070 8.817
ENSG00000175115 E004 0.0000000       11 66100763 66100874 112 +      
ENSG00000175115 E005 0.0000000       11 66121021 66121067 47 +      
ENSG00000175115 E006 48.7113872 0.0009242641 0.0331287718 0.136406032 11 66193486 66193573 88 + 1.710 1.598 -0.382
ENSG00000175115 E007 63.3539046 0.0009160581 0.0006838407 0.007302514 11 66210362 66210451 90 + 1.854 1.693 -0.545
ENSG00000175115 E008 88.4863710 0.0005847591 0.0004635653 0.005341569 11 66211134 66211259 126 + 1.981 1.841 -0.470
ENSG00000175115 E009 68.8486362 0.0008990700 0.0042285701 0.030423168 11 66216119 66216197 79 + 1.871 1.742 -0.437
ENSG00000175115 E010 65.8188179 0.0006072735 0.0807652003 0.246374296 11 66216198 66216263 66 + 1.812 1.734 -0.263
ENSG00000175115 E011 48.6005409 0.0008392679 0.2324459951 0.468008871 11 66216520 66216542 23 + 1.668 1.608 -0.205
ENSG00000175115 E012 66.3021877 0.0047757867 0.1984254532 0.427629514 11 66216543 66216611 69 + 1.801 1.731 -0.234
ENSG00000175115 E013 79.9630463 0.0013495269 0.3688068390 0.603053052 11 66216695 66216775 81 + 1.857 1.822 -0.119
ENSG00000175115 E014 1.7952049 0.1505277668 0.4337541118 0.654058671 11 66216776 66217505 730 + 0.527 0.350 -0.937
ENSG00000175115 E015 2.6611998 0.0091035072 0.8241060198 0.910352665 11 66217506 66217617 112 + 0.527 0.493 -0.166
ENSG00000175115 E016 3.2989049 0.0888029248 0.7886193654 0.889715876 11 66217618 66218697 1080 + 0.596 0.549 -0.213
ENSG00000175115 E017 0.9764321 0.0987324091 0.1882964610   11 66219545 66219745 201 + 0.445 0.184 -1.759
ENSG00000175115 E018 71.8578783 0.0129129500 0.4765638934 0.684674610 11 66219746 66219805 60 + 1.740 1.794 0.183
ENSG00000175115 E019 3.1997286 0.3365875370 0.0629664031 0.209373893 11 66220288 66220630 343 + 0.873 0.413 -2.023
ENSG00000175115 E020 64.0146270 0.0008524019 0.3505082078 0.587692993 11 66220631 66220669 39 + 1.767 1.726 -0.138
ENSG00000175115 E021 91.1668457 0.0004461241 0.4127386651 0.638179386 11 66220670 66220791 122 + 1.911 1.884 -0.091
ENSG00000175115 E022 76.7637879 0.0006426771 0.4423354801 0.660291636 11 66221154 66221247 94 + 1.835 1.807 -0.096
ENSG00000175115 E023 1.7328789 0.0133800749 0.0643882069 0.212545163 11 66221248 66221643 396 + 0.598 0.275 -1.748
ENSG00000175115 E024 65.2152299 0.0006893380 0.2025832481 0.432811178 11 66227504 66227584 81 + 1.792 1.737 -0.186
ENSG00000175115 E025 0.8513456 0.0172671820 0.9015319398   11 66230380 66230547 168 + 0.202 0.232 0.253
ENSG00000175115 E026 81.8428672 0.0004880216 0.7297227581 0.854051371 11 66230548 66230663 116 + 1.850 1.842 -0.027
ENSG00000175115 E027 87.6381630 0.0004716190 0.2946897845 0.535261451 11 66230805 66230940 136 + 1.832 1.888 0.189
ENSG00000175115 E028 0.3032425 0.0274424043 0.8484882433   11 66231794 66232171 378 + 0.000 0.131 9.955
ENSG00000175115 E029 77.8972115 0.0005499433 0.0847809056 0.254274599 11 66232172 66232276 105 + 1.753 1.845 0.311
ENSG00000175115 E030 75.9681307 0.0007093918 0.0728082551 0.230419044 11 66232960 66233066 107 + 1.739 1.836 0.328
ENSG00000175115 E031 57.9220342 0.0008921703 0.4599201113 0.673086979 11 66233785 66233819 35 + 1.662 1.711 0.165
ENSG00000175115 E032 75.9636350 0.0010184907 0.4762464843 0.684434797 11 66233820 66233909 90 + 1.784 1.828 0.149
ENSG00000175115 E033 56.1191582 0.0011893420 0.4885614840 0.693026756 11 66233910 66233939 30 + 1.651 1.698 0.160
ENSG00000175115 E034 91.9208140 0.0009020694 0.6160344976 0.781027277 11 66234132 66234242 111 + 1.875 1.905 0.102
ENSG00000175115 E035 83.6926014 0.0004530962 0.5809283184 0.757786499 11 66235301 66235403 103 + 1.828 1.861 0.113
ENSG00000175115 E036 0.4349185 0.0217681645 0.1061770650   11 66235404 66235517 114 + 0.339 0.070 -2.752
ENSG00000175115 E037 59.9334380 0.0008309013 0.8383670303 0.918547917 11 66235898 66235940 43 + 1.710 1.707 -0.010
ENSG00000175115 E038 1.0590692 0.0239596539 0.7208545489   11 66238516 66238803 288 + 0.202 0.275 0.575
ENSG00000175115 E039 57.4568082 0.0007487138 0.5780269210 0.755844383 11 66238804 66238846 43 + 1.662 1.701 0.130
ENSG00000175115 E040 102.4379529 0.0013177149 0.1625095116 0.380507835 11 66239142 66239277 136 + 1.885 1.952 0.226
ENSG00000175115 E041 0.6839606 0.0193874923 0.9125762830   11 66239278 66239739 462 + 0.202 0.184 -0.165
ENSG00000175115 E042 0.0000000       11 66240948 66241074 127 +      
ENSG00000175115 E043 0.1308682 0.0326491905 1.0000000000   11 66241227 66241426 200 + 0.000 0.070 8.946
ENSG00000175115 E044 50.6075201 0.0011746205 0.0982056796 0.278633082 11 66241427 66241447 21 + 1.555 1.664 0.371
ENSG00000175115 E045 126.6482241 0.0003830118 0.0417367291 0.159245468 11 66241448 66241653 206 + 1.964 2.050 0.288
ENSG00000175115 E046 96.5348231 0.0005023689 0.2724242528 0.512273188 11 66242912 66243031 120 + 1.944 1.907 -0.125
ENSG00000175115 E047 454.2804048 0.0039399042 0.0308975795 0.130036917 11 66243165 66244744 1580 + 2.521 2.598 0.255