ENSG00000174996

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316924 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding protein_coding 61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 6.522589 11.420481 2.037416 3.0169039 0.1905841 -2.4810101 0.10022917 0.11650000 0.04616667 -0.07033333 0.01362399 0.01362399 FALSE TRUE
ENST00000394065 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding protein_coding 61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 2.913860 3.459875 2.736068 0.9774041 0.2485562 -0.3375165 0.05272917 0.04290000 0.06216667 0.01926667 0.70418165 0.01362399 FALSE TRUE
ENST00000394067 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding protein_coding 61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 24.446493 41.992588 12.153240 10.3952914 0.6531141 -1.7879507 0.36735417 0.43096667 0.27600000 -0.15496667 0.22169070 0.01362399 FALSE TRUE
ENST00000421552 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding protein_coding 61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 2.997776 4.257360 2.499814 0.8276218 0.1547519 -0.7657634 0.05025417 0.04560000 0.05696667 0.01136667 0.75296244 0.01362399 FALSE TRUE
ENST00000534023 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding retained_intron 61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 3.946144 5.137678 5.942096 1.4339397 1.7557070 0.2094760 0.07372500 0.06363333 0.13350000 0.06986667 0.55575420 0.01362399 FALSE TRUE
MSTRG.5759.8 ENSG00000174996 HEK293_OSMI2_6hA HEK293_TMG_6hB KLC2 protein_coding   61.41175 94.2235 44.05277 15.54746 1.095063 -1.09668 13.122057 17.635977 13.532098 3.3796924 1.4032174 -0.3818880 0.22859167 0.18650000 0.30810000 0.12160000 0.13943060 0.01362399 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174996 E001 1.3450785 0.0648022710 0.997263005   11 66250295 66250339 45 + 0.330 0.354 0.150
ENSG00000174996 E002 0.8092192 0.0172671820 0.232269374   11 66257294 66257488 195 + 0.001 0.281 9.543
ENSG00000174996 E003 0.0000000       11 66257620 66257629 10 +      
ENSG00000174996 E004 0.8876225 0.0352648151 0.751274056   11 66257630 66257658 29 + 0.196 0.280 0.664
ENSG00000174996 E005 12.3938150 0.1466333711 0.806530975 0.90005207 11 66257659 66257702 44 + 0.998 1.086 0.321
ENSG00000174996 E006 13.9052307 0.1860451859 0.667975207 0.81491325 11 66257703 66257718 16 + 0.997 1.143 0.531
ENSG00000174996 E007 21.5370938 0.0138857755 0.108807640 0.29707937 11 66257719 66257730 12 + 1.131 1.334 0.719
ENSG00000174996 E008 104.6541205 0.3647577984 0.060538087 0.20404017 11 66257731 66257807 77 + 1.566 2.028 1.562
ENSG00000174996 E009 197.4219894 0.8932965054 0.243965087 0.48098264 11 66257808 66257871 64 + 1.919 2.292 1.248
ENSG00000174996 E010 41.6853531 0.1911432666 0.663683308 0.81220952 11 66258036 66258544 509 + 1.540 1.569 0.099
ENSG00000174996 E011 10.3751022 0.1783839307 0.794469891 0.89300522 11 66258545 66258546 2 + 0.976 0.995 0.069
ENSG00000174996 E012 65.8945021 0.3668909758 0.207362475 0.43863224 11 66258547 66258583 37 + 1.548 1.806 0.874
ENSG00000174996 E013 187.4943071 0.9448807662 0.331039732 0.56990958 11 66258584 66258592 9 + 1.971 2.259 0.962
ENSG00000174996 E014 457.3197014 1.3246809218 0.434498112 0.65457876 11 66258593 66258822 230 + 2.399 2.637 0.793
ENSG00000174996 E015 92.1059398 0.2190864894 0.551793163 0.73752653 11 66260913 66261741 829 + 2.016 1.857 -0.534
ENSG00000174996 E016 260.9468211 1.1199074863 0.406796888 0.63360891 11 66261742 66261835 94 + 2.165 2.393 0.761
ENSG00000174996 E017 298.1504655 0.0158732626 0.232639063 0.46823106 11 66261836 66261929 94 + 2.331 2.429 0.328
ENSG00000174996 E018 255.1304268 0.0003059638 0.216311375 0.44906219 11 66261930 66261972 43 + 2.344 2.347 0.011
ENSG00000174996 E019 342.1671944 0.0058733111 0.004668537 0.03283735 11 66262123 66262192 70 + 2.528 2.447 -0.270
ENSG00000174996 E020 25.3473865 0.2641643162 0.067839583 0.22024779 11 66262193 66262655 463 + 1.606 1.230 -1.299
ENSG00000174996 E021 488.0947161 0.0113522988 0.136450387 0.34205350 11 66262814 66262917 104 + 2.651 2.610 -0.138
ENSG00000174996 E022 625.3401224 0.0091399186 0.038685468 0.15130923 11 66262918 66263036 119 + 2.775 2.711 -0.210
ENSG00000174996 E023 11.3605057 0.1405372206 0.006854210 0.04396797 11 66263037 66263062 26 + 1.345 0.850 -1.795
ENSG00000174996 E024 397.1040143 0.0014769457 0.003228813 0.02477458 11 66263660 66263681 22 + 2.568 2.522 -0.156
ENSG00000174996 E025 563.2360547 0.0079705188 0.103091157 0.28734797 11 66263682 66263747 66 + 2.713 2.672 -0.138
ENSG00000174996 E026 524.7170992 0.0103649912 0.092330800 0.26806012 11 66263851 66263910 60 + 2.691 2.638 -0.175
ENSG00000174996 E027 453.1380932 0.0119945087 0.293934500 0.53458462 11 66263911 66263952 42 + 2.603 2.583 -0.067
ENSG00000174996 E028 717.6208247 0.0029924179 0.022464118 0.10412324 11 66264046 66264219 174 + 2.810 2.780 -0.100
ENSG00000174996 E029 504.5201565 0.0018685623 0.293989182 0.53461934 11 66264345 66264444 100 + 2.636 2.636 0.001
ENSG00000174996 E030 407.5138851 0.0771608294 0.518536884 0.71408464 11 66265023 66265072 50 + 2.497 2.555 0.194
ENSG00000174996 E031 392.3914148 1.3520970721 0.554700749 0.73956572 11 66265168 66265235 68 + 2.435 2.550 0.384
ENSG00000174996 E032 461.1118241 0.0373610778 0.272868416 0.51268775 11 66265655 66265763 109 + 2.514 2.618 0.347
ENSG00000174996 E033 497.3018499 0.0027167309 0.307896279 0.54852211 11 66265854 66266012 159 + 2.578 2.646 0.227
ENSG00000174996 E034 464.4195766 0.0064670668 0.551893788 0.73763199 11 66266093 66266217 125 + 2.549 2.614 0.217
ENSG00000174996 E035 333.3175240 0.0128435556 0.703289674 0.83772129 11 66266433 66266490 58 + 2.444 2.459 0.051
ENSG00000174996 E036 25.8587880 0.1625415126 0.181219199 0.40556638 11 66266491 66266872 382 + 1.521 1.296 -0.775
ENSG00000174996 E037 715.1824292 0.0088823124 0.779023007 0.88418132 11 66266873 66267188 316 + 2.768 2.791 0.077
ENSG00000174996 E038 655.8252029 0.0065866018 0.254118974 0.49254421 11 66267189 66267860 672 + 2.680 2.767 0.291