ENSG00000174938

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308713 ENSG00000174938 HEK293_OSMI2_6hA HEK293_TMG_6hB SEZ6L2 protein_coding protein_coding 14.52386 21.41161 5.716965 1.106106 0.4740344 -1.903224 4.836247 7.779424 1.6835137 0.4378968 0.16808367 -2.201497 0.33765833 0.36360000 0.2959000 -0.06770000 5.790098e-01 6.332917e-11 FALSE TRUE
ENST00000346932 ENSG00000174938 HEK293_OSMI2_6hA HEK293_TMG_6hB SEZ6L2 protein_coding protein_coding 14.52386 21.41161 5.716965 1.106106 0.4740344 -1.903224 2.154222 3.530053 0.8443891 0.6698752 0.38401664 -2.050806 0.12865833 0.16250000 0.1397667 -0.02273333 9.061718e-01 6.332917e-11 FALSE TRUE
ENST00000350527 ENSG00000174938 HEK293_OSMI2_6hA HEK293_TMG_6hB SEZ6L2 protein_coding protein_coding 14.52386 21.41161 5.716965 1.106106 0.4740344 -1.903224 3.805450 5.476847 0.0000000 1.1123426 0.00000000 -9.099834 0.22792083 0.25570000 0.0000000 -0.25570000 6.332917e-11 6.332917e-11 FALSE TRUE
ENST00000617533 ENSG00000174938 HEK293_OSMI2_6hA HEK293_TMG_6hB SEZ6L2 protein_coding protein_coding 14.52386 21.41161 5.716965 1.106106 0.4740344 -1.903224 1.702202 1.298264 2.7961278 1.2982642 0.35982453 1.100927 0.18337083 0.06686667 0.4923667 0.42550000 1.010887e-01 6.332917e-11 FALSE TRUE
MSTRG.12411.8 ENSG00000174938 HEK293_OSMI2_6hA HEK293_TMG_6hB SEZ6L2 protein_coding   14.52386 21.41161 5.716965 1.106106 0.4740344 -1.903224 1.550037 1.991984 0.3929347 0.4519995 0.09657365 -2.312813 0.09258333 0.09186667 0.0720000 -0.01986667 8.794187e-01 6.332917e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174938 E001 0.5363366 0.0684587858 7.174861e-01   16 29871159 29871160 2 - 0.001 0.163 7.795
ENSG00000174938 E002 36.4264982 0.0010823690 1.107290e-01 0.300182577 16 29871161 29871316 156 - 1.351 1.476 0.432
ENSG00000174938 E003 33.5584792 0.0013242687 3.306642e-01 0.569617238 16 29871317 29871335 19 - 1.364 1.441 0.267
ENSG00000174938 E004 226.0235990 0.0020767352 2.897160e-03 0.022782845 16 29871336 29871728 393 - 2.148 2.257 0.366
ENSG00000174938 E005 178.3536714 0.0038806197 7.480689e-02 0.234424461 16 29872187 29872283 97 - 2.071 2.148 0.261
ENSG00000174938 E006 219.4803754 0.0022720458 4.169414e-01 0.641347155 16 29872409 29872526 118 - 2.202 2.230 0.094
ENSG00000174938 E007 87.6160842 0.0015298588 4.410389e-01 0.659504052 16 29872705 29872743 39 - 1.867 1.827 -0.132
ENSG00000174938 E008 240.2110492 0.0003380905 1.009234e-01 0.283459689 16 29873240 29873431 192 - 2.228 2.275 0.160
ENSG00000174938 E009 259.5538323 0.0001919201 2.269647e-02 0.104956203 16 29873538 29873729 192 - 2.245 2.309 0.212
ENSG00000174938 E010 101.4362157 0.0030479626 1.475162e-02 0.077146062 16 29876756 29876764 9 - 1.781 1.913 0.443
ENSG00000174938 E011 158.5525899 0.0022866538 9.701833e-04 0.009676363 16 29876765 29876853 89 - 1.961 2.105 0.480
ENSG00000174938 E012 158.5051662 0.0005005646 2.386400e-02 0.108677695 16 29876854 29876950 97 - 2.014 2.098 0.283
ENSG00000174938 E013 171.7646839 0.0003800729 6.081291e-03 0.040131712 16 29877271 29877467 197 - 2.039 2.138 0.331
ENSG00000174938 E014 99.5904016 0.0062362980 3.046525e-01 0.545231443 16 29878287 29878425 139 - 1.931 1.873 -0.196
ENSG00000174938 E015 119.8850511 0.0096700493 3.703701e-02 0.146997684 16 29879864 29880064 201 - 2.063 1.942 -0.406
ENSG00000174938 E016 103.7641410 0.0006302868 8.889322e-03 0.053320545 16 29885586 29885749 164 - 1.996 1.883 -0.380
ENSG00000174938 E017 0.5365243 0.0241119978 4.996325e-01   16 29885750 29886019 270 - 0.228 0.115 -1.195
ENSG00000174938 E018 100.4775408 0.0026490426 3.268930e-02 0.135194283 16 29887649 29887817 169 - 1.974 1.871 -0.349
ENSG00000174938 E019 116.7936434 0.0013191849 4.041387e-04 0.004770421 16 29888540 29888725 186 - 2.071 1.922 -0.500
ENSG00000174938 E020 101.2842307 0.0023198645 2.238970e-03 0.018653291 16 29895259 29895460 202 - 2.006 1.861 -0.485
ENSG00000174938 E021 58.5463023 0.0063897953 4.890401e-01 0.693368215 16 29895721 29895860 140 - 1.694 1.646 -0.164
ENSG00000174938 E022 32.2649753 0.0100842895 1.716488e-01 0.392729031 16 29896822 29896911 90 - 1.507 1.386 -0.418
ENSG00000174938 E023 19.8249268 0.0257335420 5.905708e-02 0.200653223 16 29896912 29896958 47 - 1.379 1.163 -0.759
ENSG00000174938 E024 52.3964138 0.0008547642 2.848006e-02 0.122749313 16 29896959 29897121 163 - 1.717 1.587 -0.443
ENSG00000174938 E025 61.1938354 0.0007779391 2.381022e-04 0.003089960 16 29897853 29897984 132 - 1.833 1.635 -0.668
ENSG00000174938 E026 100.9822102 0.0016254291 7.402562e-05 0.001163359 16 29898941 29899550 610 - 2.034 1.856 -0.597