ENSG00000174839

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311128 ENSG00000174839 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6A protein_coding protein_coding 16.49466 3.898159 28.30403 0.5329128 1.287395 2.856956 11.8704509 3.19683439 19.728614 0.25250679 0.7454622 2.621799 0.77543333 0.837766667 0.69756667 -0.14020000 0.62244904 0.0240925 FALSE TRUE
MSTRG.23144.6 ENSG00000174839 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6A protein_coding   16.49466 3.898159 28.30403 0.5329128 1.287395 2.856956 1.9451884 0.04611037 2.953825 0.04611037 0.6423632 5.723049 0.07918750 0.010266667 0.10290000 0.09263333 0.02796393 0.0240925 FALSE TRUE
MSTRG.23144.7 ENSG00000174839 HEK293_OSMI2_6hA HEK293_TMG_6hB DENND6A protein_coding   16.49466 3.898159 28.30403 0.5329128 1.287395 2.856956 0.7760896 0.03387667 2.302811 0.03387667 0.4705857 5.720049 0.02812083 0.007533333 0.08323333 0.07570000 0.02409250 0.0240925 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174839 E001 270.6925100 1.609645556 0.41648288 0.64102671 3 57625454 57626402 949 - 2.194 2.545 1.170
ENSG00000174839 E002 35.8815770 0.676079815 0.32069225 0.56030329 3 57626403 57626420 18 - 1.348 1.633 0.980
ENSG00000174839 E003 18.6379669 0.435623071 0.15338148 0.36715388 3 57626421 57626432 12 - 1.047 1.466 1.477
ENSG00000174839 E004 8.4193503 0.187763851 0.01275041 0.06943666 3 57626433 57626449 17 - 0.686 1.290 2.265
ENSG00000174839 E005 134.2080020 1.343190126 0.32960551 0.56858883 3 57626450 57627437 988 - 1.876 2.290 1.390
ENSG00000174839 E006 74.8305112 0.881800915 0.24042746 0.47705974 3 57627438 57627814 377 - 1.619 2.057 1.478
ENSG00000174839 E007 98.2468929 1.267787390 0.50609944 0.70501793 3 57627815 57628085 271 - 1.786 2.012 0.761
ENSG00000174839 E008 145.3624683 1.412476589 0.53016704 0.72219047 3 57628086 57628345 260 - 1.956 2.172 0.726
ENSG00000174839 E009 84.0886551 0.586312704 0.38044452 0.61256253 3 57628811 57628885 75 - 1.720 1.944 0.758
ENSG00000174839 E010 2.0271383 0.600048926 0.52589582 0.71918803 3 57630349 57630420 72 - 0.289 0.682 2.011
ENSG00000174839 E011 98.1086745 0.026083635 0.83927112 0.91899298 3 57630421 57630523 103 - 1.806 1.919 0.381
ENSG00000174839 E012 75.0015560 0.006128523 0.04987312 0.17934955 3 57630715 57630738 24 - 1.708 1.699 -0.032
ENSG00000174839 E013 99.5274312 0.013607814 0.18682238 0.41280419 3 57630739 57630824 86 - 1.822 1.861 0.134
ENSG00000174839 E014 74.0258535 0.022270679 0.40332830 0.63096814 3 57630925 57630978 54 - 1.691 1.764 0.246
ENSG00000174839 E015 1.0235477 0.240198027 0.43302494   3 57630979 57631184 206 - 0.174 0.437 1.813
ENSG00000174839 E016 79.8945796 0.028883101 0.28997498 0.53055468 3 57633265 57633354 90 - 1.727 1.775 0.163
ENSG00000174839 E017 74.6273049 0.028139109 0.13174687 0.33454922 3 57634558 57634622 65 - 1.704 1.703 -0.004
ENSG00000174839 E018 71.9323923 0.027009352 0.03289997 0.13578892 3 57634704 57634769 66 - 1.697 1.622 -0.252
ENSG00000174839 E019 96.9040456 0.034967185 0.01446798 0.07612928 3 57641653 57641747 95 - 1.827 1.723 -0.350
ENSG00000174839 E020 82.5132981 0.024399235 0.04458586 0.16656849 3 57645661 57645756 96 - 1.752 1.705 -0.158
ENSG00000174839 E021 76.9567337 0.025944979 0.12604150 0.32556232 3 57646316 57646438 123 - 1.717 1.713 -0.014
ENSG00000174839 E022 0.5008152 0.052225668 0.96588858   3 57657651 57657679 29 - 0.135 0.001 -6.994
ENSG00000174839 E023 61.4739399 0.026338337 0.02826545 0.12206215 3 57657680 57657735 56 - 1.631 1.551 -0.272
ENSG00000174839 E024 72.8999599 0.048857326 0.10385435 0.28861491 3 57659118 57659180 63 - 1.701 1.649 -0.177
ENSG00000174839 E025 90.3203661 0.050632145 0.22599395 0.46056607 3 57660760 57660839 80 - 1.786 1.784 -0.006
ENSG00000174839 E026 96.4222562 0.041899855 0.28718865 0.52795934 3 57661446 57661551 106 - 1.810 1.835 0.085
ENSG00000174839 E027 78.6857706 0.042484551 0.16414439 0.38287883 3 57663636 57663713 78 - 1.726 1.721 -0.018
ENSG00000174839 E028 36.7753110 0.100896351 0.04898260 0.17719141 3 57663714 57663716 3 - 1.428 1.196 -0.812
ENSG00000174839 E029 4.8380546 0.032905927 0.97083209 0.98724487 3 57665961 57666122 162 - 0.606 0.724 0.497
ENSG00000174839 E030 74.9062221 0.059656103 0.03545203 0.14276226 3 57666123 57666235 113 - 1.721 1.581 -0.477
ENSG00000174839 E031 42.5643732 0.065550031 0.09914612 0.28026652 3 57672256 57672298 43 - 1.480 1.377 -0.354
ENSG00000174839 E032 41.1505537 0.080362136 0.08916328 0.26224412 3 57672400 57672438 39 - 1.469 1.340 -0.444
ENSG00000174839 E033 14.5296102 0.084130398 0.01905022 0.09264501 3 57679487 57679725 239 - 1.056 0.728 -1.254
ENSG00000174839 E034 47.4699750 0.099236522 0.55094283 0.73700361 3 57692782 57693117 336 - 1.507 1.562 0.186