ENSG00000174796

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311638 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding protein_coding 5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 2.18644968 0.8453591 4.2131515 0.12113012 0.23519319 2.3037178 0.32708333 0.22783333 0.49276667 0.264933333 8.569177e-05 8.569177e-05 FALSE TRUE
ENST00000504190 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding protein_coding 5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.27293602 0.3339176 0.1818032 0.16729783 0.07047232 -0.8424362 0.04706250 0.08580000 0.02126667 -0.064533333 7.384307e-01 8.569177e-05   FALSE
ENST00000507556 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding protein_coding 5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.55333078 0.3092680 0.8086468 0.30926802 0.23457326 1.3584731 0.09953750 0.09636667 0.09143333 -0.004933333 6.313246e-01 8.569177e-05 FALSE TRUE
ENST00000514480 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding protein_coding 5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.51067243 0.1672637 0.6563735 0.05456896 0.27731272 1.9104339 0.07353750 0.04790000 0.07443333 0.026533333 9.005057e-01 8.569177e-05 FALSE TRUE
MSTRG.25027.10 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding   5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.31514894 0.7496568 0.1858344 0.61272651 0.18583444 -1.9557133 0.05320000 0.18720000 0.02136667 -0.165833333 6.663386e-01 8.569177e-05 FALSE TRUE
MSTRG.25027.3 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding   5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.84515231 0.4693259 0.9940509 0.24699839 0.06451692 1.0667536 0.16604583 0.13753333 0.11616667 -0.021366667 9.718213e-01 8.569177e-05 TRUE TRUE
MSTRG.25027.7 ENSG00000174796 HEK293_OSMI2_6hA HEK293_TMG_6hB THAP6 protein_coding   5.886461 3.671286 8.605144 0.2448509 0.7741712 1.226665 0.09167878 0.1975407 0.0000000 0.19754069 0.00000000 -4.3753223 0.02861667 0.05253333 0.00000000 -0.052533333 7.656744e-01 8.569177e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174796 E001 0.3559677 0.6064058798 7.359977e-01   4 75513946 75513998 53 + 0.142 0.000 -8.658
ENSG00000174796 E002 0.2617363 0.1912789312 7.429188e-02   4 75514218 75514437 220 + 0.000 0.319 12.921
ENSG00000174796 E003 0.0000000       4 75514438 75514443 6 +      
ENSG00000174796 E004 0.0000000       4 75514444 75514453 10 +      
ENSG00000174796 E005 2.4372498 0.0191694340 7.383066e-01 0.8594422110 4 75514454 75514472 19 + 0.459 0.577 0.567
ENSG00000174796 E006 4.1285204 0.0060719099 7.950934e-01 0.8934193814 4 75514473 75514478 6 + 0.659 0.689 0.124
ENSG00000174796 E007 10.7744269 0.0035546580 1.263797e-01 0.3260687571 4 75514479 75514487 9 + 1.039 0.943 -0.356
ENSG00000174796 E008 11.6913796 0.0031086191 9.533043e-02 0.2735510649 4 75514488 75514488 1 + 1.075 0.969 -0.387
ENSG00000174796 E009 12.2689327 0.0027718469 9.542137e-02 0.2737426411 4 75514489 75514490 2 + 1.095 0.994 -0.367
ENSG00000174796 E010 13.7583064 0.0024237364 2.175555e-01 0.4504886605 4 75514491 75514493 3 + 1.126 1.083 -0.158
ENSG00000174796 E011 21.1743966 0.0017829727 1.264529e-01 0.3261707394 4 75514494 75514519 26 + 1.304 1.260 -0.154
ENSG00000174796 E012 21.1743966 0.0017829727 1.264529e-01 0.3261707394 4 75514520 75514520 1 + 1.304 1.260 -0.154
ENSG00000174796 E013 3.8499599 0.1725021162 9.779608e-01 0.9907489984 4 75514521 75514869 349 + 0.638 0.680 0.180
ENSG00000174796 E014 4.0588511 0.2161364198 7.465035e-01 0.8646776209 4 75514870 75514991 122 + 0.635 0.734 0.414
ENSG00000174796 E015 34.5793947 0.0010555015 6.390643e-01 0.7962946099 4 75515433 75515532 100 + 1.481 1.535 0.187
ENSG00000174796 E016 53.4231734 0.0009054993 5.057823e-01 0.7048023321 4 75516772 75516979 208 + 1.665 1.716 0.176
ENSG00000174796 E017 2.1537160 0.0098799337 9.519089e-01 0.9779139701 4 75516980 75517720 741 + 0.459 0.507 0.240
ENSG00000174796 E018 30.4909850 0.0022000982 9.438117e-02 0.2718838079 4 75521736 75521861 126 + 1.458 1.423 -0.120
ENSG00000174796 E019 3.0992930 0.0079275251 8.275384e-01 0.9123638739 4 75521862 75522582 721 + 0.536 0.637 0.449
ENSG00000174796 E020 49.8494425 0.0007502213 9.223264e-06 0.0001956436 4 75526960 75527429 470 + 1.689 1.521 -0.571
ENSG00000174796 E021 23.3019151 0.0019077794 5.391666e-03 0.0366594665 4 75527430 75527598 169 + 1.367 1.218 -0.521
ENSG00000174796 E022 138.4088873 0.0211830810 1.267931e-03 0.0119154401 4 75527599 75530026 2428 + 2.113 1.999 -0.382
ENSG00000174796 E023 5.9657815 0.0914549936 8.056369e-02 0.2459740161 4 75539859 75539959 101 + 0.671 1.055 1.491
ENSG00000174796 E024 10.5071133 0.2138621678 2.688447e-02 0.1179530335 4 75542409 75542486 78 + 0.816 1.323 1.851
ENSG00000174796 E025 9.2142461 0.1827030294 3.969064e-02 0.1539287332 4 75542487 75542552 66 + 0.786 1.250 1.717
ENSG00000174796 E026 11.3688423 0.2348554743 1.353226e-02 0.0724857570 4 75542553 75543055 503 + 0.780 1.404 2.274
ENSG00000174796 E027 24.9091963 0.3527685624 4.855344e-03 0.0338470943 4 75544328 75544692 365 + 1.003 1.776 2.694
ENSG00000174796 E028 20.7824695 0.1811724614 2.366748e-05 0.0004409525 4 75546974 75547198 225 + 0.822 1.746 3.280
ENSG00000174796 E029 0.2922838 0.0276783506 5.190844e-01   4 75549605 75549720 116 + 0.075 0.191 1.561
ENSG00000174796 E030 0.0000000       4 75550336 75550473 138 +