ENSG00000174748

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307839 ENSG00000174748 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL15 protein_coding protein_coding 4031.197 4388.124 2515.988 1127.093 126.705 -0.802477 283.9454 113.5391 346.2750 29.63227 10.00227 1.608643 0.08684167 0.0262 0.1379667 0.111766667 2.063231e-34 2.063231e-34 FALSE TRUE
ENST00000412097 ENSG00000174748 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL15 protein_coding protein_coding 4031.197 4388.124 2515.988 1127.093 126.705 -0.802477 890.8187 1044.0331 390.3768 272.45523 26.11805 -1.419205 0.20777083 0.2365 0.1549000 -0.081600000 4.283768e-04 2.063231e-34 FALSE TRUE
ENST00000645079 ENSG00000174748 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL15 protein_coding protein_coding 4031.197 4388.124 2515.988 1127.093 126.705 -0.802477 2535.7517 2771.3570 1603.0104 724.39363 85.00428 -0.789805 0.62624167 0.6306 0.6369667 0.006366667 9.574659e-01 2.063231e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174748 E001 1.565786e+00 0.0121989077 5.704712e-03 3.826341e-02 3 23916591 23916768 178 + 0.000 0.523 11.999
ENSG00000174748 E002 9.097275e-01 0.2936885974 8.246419e-02   3 23916804 23916978 175 + 0.000 0.375 11.234
ENSG00000174748 E003 6.130659e+00 0.0206937162 7.572207e-01 8.709995e-01 3 23916979 23917095 117 + 0.831 0.836 0.018
ENSG00000174748 E004 4.973390e+01 0.0008695899 3.735934e-01 6.070343e-01 3 23917096 23917131 36 + 1.670 1.684 0.045
ENSG00000174748 E005 6.257407e+01 0.0007306196 7.305910e-01 8.545430e-01 3 23917132 23917137 6 + 1.789 1.771 -0.060
ENSG00000174748 E006 7.298179e+01 0.0050659348 3.804759e-01 6.125901e-01 3 23917138 23917138 1 + 1.897 1.812 -0.287
ENSG00000174748 E007 1.054800e+03 0.0091475771 3.600094e-01 5.957403e-01 3 23917139 23917146 8 + 3.055 2.968 -0.291
ENSG00000174748 E008 1.056235e+03 0.0091348254 3.674386e-01 6.019401e-01 3 23917147 23917147 1 + 3.055 2.969 -0.288
ENSG00000174748 E009 5.584459e+03 0.0003864667 2.501166e-07 8.405787e-06 3 23917148 23917173 26 + 3.709 3.730 0.070
ENSG00000174748 E010 1.277960e+03 0.0017889746 7.266403e-03 4.590953e-02 3 23917174 23917239 66 + 3.066 3.090 0.081
ENSG00000174748 E011 3.445094e+02 0.0050469622 1.783008e-01 4.016232e-01 3 23917240 23917268 29 + 2.506 2.518 0.039
ENSG00000174748 E012 3.145586e+02 0.0062440208 5.816492e-01 7.581796e-01 3 23917269 23917295 27 + 2.487 2.468 -0.064
ENSG00000174748 E013 2.684354e+01 0.1164851161 3.496584e-02 1.414908e-01 3 23917296 23917298 3 + 1.653 1.227 -1.470
ENSG00000174748 E014 5.874208e+01 0.0953816950 2.904605e-02 1.244905e-01 3 23917299 23917444 146 + 1.974 1.571 -1.362
ENSG00000174748 E015 2.290234e+01 0.3184971996 1.234155e-01 3.211669e-01 3 23917445 23917532 88 + 1.596 1.150 -1.551
ENSG00000174748 E016 3.264250e+01 0.1770081794 1.021584e-01 2.856242e-01 3 23917533 23917665 133 + 1.721 1.331 -1.336
ENSG00000174748 E017 2.182548e+01 0.0790258738 3.202918e-02 1.333062e-01 3 23917666 23917704 39 + 1.547 1.166 -1.324
ENSG00000174748 E018 4.222584e+01 0.0773761846 2.598191e-02 1.152585e-01 3 23917705 23917836 132 + 1.820 1.446 -1.276
ENSG00000174748 E019 6.713116e+01 0.0015745640 2.671327e-01 5.067557e-01 3 23917837 23917849 13 + 1.861 1.772 -0.300
ENSG00000174748 E020 9.214266e+03 0.0006274162 2.435961e-13 2.825698e-11 3 23917850 23917946 97 + 3.901 3.959 0.193
ENSG00000174748 E021 6.889402e+03 0.0014303055 3.008050e-08 1.264133e-06 3 23917947 23917972 26 + 3.767 3.837 0.233
ENSG00000174748 E022 1.199630e+04 0.0005128781 2.340168e-18 5.613197e-16 3 23917973 23918031 59 + 4.012 4.075 0.209
ENSG00000174748 E023 5.686903e+01 0.0166361403 1.405785e-04 1.986641e-03 3 23918032 23918439 408 + 1.933 1.586 -1.174
ENSG00000174748 E024 1.956046e+04 0.0002401901 2.490226e-13 2.880774e-11 3 23918440 23918576 137 + 4.253 4.274 0.070
ENSG00000174748 E025 1.665450e+02 0.0075663829 1.322751e-01 3.353712e-01 3 23918577 23918583 7 + 2.155 2.217 0.206
ENSG00000174748 E026 1.134844e+02 0.0022900511 3.290143e-22 1.258428e-19 3 23918584 23919195 612 + 2.264 1.835 -1.440
ENSG00000174748 E027 1.306329e+04 0.0002135173 2.313451e-05 4.327794e-04 3 23919196 23919202 7 + 4.090 4.092 0.005
ENSG00000174748 E028 1.554082e+04 0.0002953292 1.877551e-05 3.621665e-04 3 23919203 23919246 44 + 4.163 4.169 0.020
ENSG00000174748 E029 1.777421e+04 0.0005746177 8.869618e-01 9.450897e-01 3 23919247 23919506 260 + 4.244 4.216 -0.091
ENSG00000174748 E030 7.367581e+03 0.0026098991 1.194044e-131 1.152193e-126 3 23919507 23920989 1483 + 4.151 3.517 -2.104
ENSG00000174748 E031 6.962911e+01 0.0511910261 3.838978e-01 6.155206e-01 3 23921598 23924003 2406 + 1.923 1.765 -0.530
ENSG00000174748 E032 3.042522e+01 0.3536160105 2.277061e-01 4.626286e-01 3 23924004 23924374 371 + 1.801 1.099 -2.426