ENSG00000174669

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357440 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding protein_coding 25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 6.899345 10.971744 5.436803 1.6786855 0.39479220 -1.0116255 0.2667167 0.30666667 0.24846667 -0.05820000 0.796811638 0.007151767 FALSE  
ENST00000619145 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding protein_coding 25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 3.040415 5.400222 1.823263 0.5260155 0.11046365 -1.5612736 0.1161083 0.15000000 0.08333333 -0.06666667 0.007151767 0.007151767 FALSE  
MSTRG.5772.14 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding   25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 3.549221 4.099239 5.031651 1.1838640 0.17326659 0.2950252 0.1429833 0.11530000 0.23023333 0.11493333 0.205362435 0.007151767    
MSTRG.5772.17 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding   25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 4.787983 6.314345 4.654793 0.6341305 0.21277996 -0.4391029 0.1900792 0.17623333 0.21283333 0.03660000 0.675467848 0.007151767 FALSE  
MSTRG.5772.2 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding   25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 1.344677 1.162671 1.316085 0.3363424 0.10574932 0.1773751 0.0533500 0.03226667 0.06013333 0.02786667 0.391092317 0.007151767    
MSTRG.5772.4 ENSG00000174669 HEK293_OSMI2_6hA HEK293_TMG_6hB SLC29A2 protein_coding   25.52721 35.84717 21.85166 2.001231 0.6572268 -0.7138588 3.329563 5.225067 2.337793 0.7850922 0.08650155 -1.1569032 0.1280917 0.14480000 0.10740000 -0.03740000 0.593239700 0.007151767 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174669 E001 19.090981 0.0138619286 0.0005329509 0.005975658 11 66360351 66362198 1848 - 1.457 1.155 -1.053
ENSG00000174669 E002 3.831342 0.1294050645 0.0480702638 0.175149789 11 66362199 66362474 276 - 0.869 0.501 -1.560
ENSG00000174669 E003 2.569813 0.0269548305 0.7694816960 0.878310758 11 66362475 66362520 46 - 0.535 0.500 -0.170
ENSG00000174669 E004 2.589574 0.0380909824 0.7910210330 0.891089769 11 66362521 66362521 1 - 0.468 0.530 0.303
ENSG00000174669 E005 2.792308 0.0759851468 0.6882939701 0.827989792 11 66362522 66362522 1 - 0.468 0.561 0.449
ENSG00000174669 E006 372.562661 0.0019412458 0.2500549198 0.487996596 11 66362523 66363138 616 - 2.499 2.553 0.178
ENSG00000174669 E007 303.195891 0.1164123430 0.1221565344 0.319271564 11 66363139 66363495 357 - 2.281 2.502 0.739
ENSG00000174669 E008 77.987410 0.5896032668 0.2077780989 0.439136550 11 66363496 66363496 1 - 1.595 1.940 1.166
ENSG00000174669 E009 107.737107 0.7059942614 0.2372113891 0.473344101 11 66363497 66363547 51 - 1.735 2.078 1.154
ENSG00000174669 E010 207.849501 0.0158218728 0.0296253942 0.126228098 11 66364225 66364424 200 - 2.169 2.326 0.525
ENSG00000174669 E011 14.077191 0.1152479315 0.1742434127 0.396172753 11 66364425 66364751 327 - 1.291 1.067 -0.799
ENSG00000174669 E012 174.846699 0.0027922193 0.5473604402 0.734382316 11 66365936 66366021 86 - 2.210 2.212 0.006
ENSG00000174669 E013 25.649155 0.0334540778 0.0296247048 0.126228098 11 66366022 66366125 104 - 1.527 1.311 -0.744
ENSG00000174669 E014 161.363713 0.0092858179 0.5377369345 0.727476296 11 66366126 66366191 66 - 2.183 2.172 -0.037
ENSG00000174669 E015 113.413834 0.0074800279 0.8024182761 0.897728235 11 66366192 66366231 40 - 2.019 2.024 0.016
ENSG00000174669 E016 50.200963 0.0528747850 0.0009324825 0.009358607 11 66366232 66366430 199 - 1.887 1.531 -1.208
ENSG00000174669 E017 169.522482 0.0003189400 0.0009551842 0.009549199 11 66366431 66366564 134 - 2.244 2.174 -0.235
ENSG00000174669 E018 86.814899 0.0750769473 0.0041180863 0.029828629 11 66366565 66367052 488 - 2.106 1.780 -1.095
ENSG00000174669 E019 183.970270 0.0003813333 0.8929734219 0.948128254 11 66367464 66367548 85 - 2.217 2.238 0.070
ENSG00000174669 E020 174.514358 0.0010611426 0.7701888090 0.878732207 11 66367772 66367869 98 - 2.185 2.218 0.110
ENSG00000174669 E021 182.712494 0.0004808384 0.0685326503 0.221806718 11 66368537 66368671 135 - 2.247 2.219 -0.094
ENSG00000174669 E022 118.561701 0.0135290291 0.0060738696 0.040094953 11 66368672 66369059 388 - 2.139 1.991 -0.495
ENSG00000174669 E023 111.066517 0.0050854750 0.2323345330 0.467934243 11 66369060 66369131 72 - 2.038 2.002 -0.119
ENSG00000174669 E024 54.999672 0.0044362620 0.0501683028 0.180094525 11 66369132 66369134 3 - 1.773 1.684 -0.302
ENSG00000174669 E025 79.514342 0.0069526583 0.1893977406 0.416209431 11 66369135 66369199 65 - 1.905 1.854 -0.172
ENSG00000174669 E026 45.268218 0.0015255628 0.2517433741 0.489770817 11 66369200 66369368 169 - 1.659 1.619 -0.138
ENSG00000174669 E027 142.173020 0.0032524255 0.5552468300 0.739950795 11 66369369 66369532 164 - 2.120 2.119 -0.004
ENSG00000174669 E028 76.529392 0.0095039244 0.8904625101 0.946924581 11 66371244 66371325 82 - 1.831 1.863 0.107
ENSG00000174669 E029 48.420507 0.0008494574 0.0206354502 0.098134187 11 66371563 66371611 49 - 1.543 1.702 0.540
ENSG00000174669 E030 39.258594 0.0010237665 0.0180874733 0.089321511 11 66371612 66371646 35 - 1.442 1.619 0.605
ENSG00000174669 E031 40.926979 0.0039897324 0.0007197870 0.007610284 11 66371647 66371779 133 - 1.394 1.659 0.908
ENSG00000174669 E032 4.432394 0.0062023719 0.9278270381 0.965971487 11 66371780 66371820 41 - 0.688 0.723 0.144
ENSG00000174669 E033 5.040524 0.0051067629 0.2066742424 0.437724342 11 66372010 66372214 205 - 0.592 0.804 0.884
ENSG00000174669 E034 0.000000       11 66374883 66374920 38 -