ENSG00000174606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360506 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding protein_coding 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 1.6636662 0.4837199 1.8583413 0.14437652 0.2726085 1.9199934 0.13402083 0.10476667 0.09033333 -0.01443333 9.888502e-01 1.306001e-12 FALSE TRUE
ENST00000366962 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding protein_coding 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 5.1536280 2.0081234 7.3279994 0.69967487 0.2125129 1.8623724 0.36302083 0.37850000 0.35036667 -0.02813333 9.973036e-01 1.306001e-12 FALSE TRUE
ENST00000460337 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding processed_transcript 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 0.5782365 0.2026833 0.7672965 0.13847379 0.1226594 1.8697580 0.05234167 0.03496667 0.03766667 0.00270000 9.427808e-01 1.306001e-12 FALSE TRUE
ENST00000473303 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding processed_transcript 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 0.8806650 0.4806890 1.3737733 0.07382657 0.0184732 1.4957268 0.07069583 0.10416667 0.06583333 -0.03833333 7.276518e-01 1.306001e-12   FALSE
ENST00000481918 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding processed_transcript 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 2.1230697 0.1926614 2.0900645 0.19266144 1.0476553 3.3732901 0.12584167 0.05060000 0.09436667 0.04376667 7.754040e-01 1.306001e-12   FALSE
ENST00000498650 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding processed_transcript 14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 0.5183722 0.5486412 0.4405291 0.16412739 0.2332510 -0.3103018 0.05015000 0.12316667 0.02030000 -0.10286667 3.985579e-01 1.306001e-12   FALSE
MSTRG.3038.7 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding   14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 0.6778210 0.3755132 0.4120681 0.09879542 0.1735525 0.1306957 0.04621667 0.07503333 0.01870000 -0.05633333 8.231891e-02 1.306001e-12 FALSE TRUE
MSTRG.3038.9 ENSG00000174606 HEK293_OSMI2_6hA HEK293_TMG_6hB ANGEL2 protein_coding   14.86385 4.98678 21.07664 0.6447762 1.608402 2.077258 2.1666680 0.0000000 3.8091875 0.00000000 0.6594837 8.5771219 0.09176250 0.00000000 0.17853333 0.17853333 1.306001e-12 1.306001e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174606 E001 241.4593310 0.0013667496 2.658945e-04 3.384679e-03 1 212992182 212993991 1810 - 2.286 2.394 0.359
ENSG00000174606 E002 143.9391081 0.0003065640 8.006159e-02 2.449607e-01 1 212993992 212994728 737 - 2.102 2.050 -0.172
ENSG00000174606 E003 33.0824570 0.0259176853 7.862087e-01 8.882435e-01 1 212994729 212994845 117 - 1.452 1.473 0.073
ENSG00000174606 E004 22.2631981 0.0794463375 6.157309e-01 7.808044e-01 1 212994846 212994927 82 - 1.266 1.375 0.380
ENSG00000174606 E005 16.6826531 0.0479093305 1.127662e-01 3.037674e-01 1 212994928 212994938 11 - 1.112 1.336 0.793
ENSG00000174606 E006 102.2686882 0.0008148528 9.904434e-01 9.969479e-01 1 212994939 212995192 254 - 1.941 1.950 0.031
ENSG00000174606 E007 61.1851188 0.0006856666 5.657103e-01 7.471662e-01 1 212997155 212997199 45 - 1.731 1.710 -0.072
ENSG00000174606 E008 86.8421109 0.0005463070 4.286350e-01 6.500395e-01 1 212997200 212997318 119 - 1.881 1.854 -0.090
ENSG00000174606 E009 55.1439830 0.0008186212 8.222966e-01 9.092848e-01 1 213000326 213000379 54 - 1.679 1.700 0.072
ENSG00000174606 E010 37.5927428 0.0021283905 9.254074e-01 9.648720e-01 1 213000380 213000383 4 - 1.522 1.525 0.010
ENSG00000174606 E011 2.5119259 0.1338864198 1.246338e-02 6.830284e-02 1 213000384 213000570 187 - 0.314 0.807 2.350
ENSG00000174606 E012 65.2559317 0.0009037182 5.057825e-01 7.048023e-01 1 213000786 213000912 127 - 1.760 1.734 -0.086
ENSG00000174606 E013 33.0213604 0.1288815598 3.288089e-01 5.677943e-01 1 213000913 213002234 1322 - 1.412 1.591 0.614
ENSG00000174606 E014 60.0458336 0.0007421713 1.364436e-02 7.295280e-02 1 213005033 213005124 92 - 1.744 1.615 -0.436
ENSG00000174606 E015 120.1749664 0.0005100295 2.560012e-02 1.140505e-01 1 213005125 213005454 330 - 2.029 1.951 -0.263
ENSG00000174606 E016 7.0784269 0.0367402676 5.903326e-01 7.639543e-01 1 213006539 213007128 590 - 0.831 0.933 0.392
ENSG00000174606 E017 61.1598058 0.0006293115 2.759039e-01 5.159883e-01 1 213007129 213007198 70 - 1.734 1.685 -0.168
ENSG00000174606 E018 119.8857495 0.0032952897 2.485662e-01 4.863403e-01 1 213008210 213008466 257 - 2.021 1.977 -0.148
ENSG00000174606 E019 3.5710377 0.1330821408 7.750610e-01 8.817775e-01 1 213011208 213011463 256 - 0.623 0.526 -0.438
ENSG00000174606 E020 116.5558401 0.0048588455 2.623843e-02 1.160478e-01 1 213013093 213013418 326 - 2.021 1.917 -0.347
ENSG00000174606 E021 4.3972329 0.0068892319 1.110752e-06 3.111186e-05 1 213015149 213015225 77 - 0.412 1.088 2.829
ENSG00000174606 E022 21.5624032 0.0021182517 7.766050e-03 4.820725e-02 1 213015226 213015438 213 - 1.230 1.450 0.767
ENSG00000174606 E023 8.7661581 0.0039732445 1.378861e-01 3.442747e-01 1 213015439 213015608 170 - 0.885 1.066 0.674
ENSG00000174606 E024 0.1779838 0.0391421549 1.000000e+00   1 213015609 213015612 4 - 0.070 0.001 -6.700
ENSG00000174606 E025 25.7431963 0.0014364081 7.114496e-01 8.427475e-01 1 213015613 213015653 41 - 1.354 1.392 0.131
ENSG00000174606 E026 34.3298517 0.0058219167 5.793469e-01 7.567022e-01 1 213015654 213015867 214 - 1.490 1.458 -0.111