ENSG00000174501

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295246 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding protein_coding 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.19599163 0.09988597 0.37307596 0.05296913 0.05487559 1.801623 0.13411667 0.15376667 0.15806667 0.00430000 0.986193737 0.002400185 FALSE TRUE
ENST00000456556 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding protein_coding 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.03469689 0.11017289 0.00000000 0.01916065 0.00000000 -3.587040 0.04979583 0.31390000 0.00000000 -0.31390000 0.016541981 0.002400185 FALSE TRUE
ENST00000528268 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding nonsense_mediated_decay 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.09327273 0.04710230 0.10596612 0.04710230 0.10596612 1.022083 0.06474167 0.04090000 0.04570000 0.00480000 0.894179118 0.002400185 TRUE TRUE
ENST00000531153 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding retained_intron 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.13153552 0.07807243 0.23590959 0.06365964 0.04396543 1.481366 0.08410000 0.08016667 0.09976667 0.01960000 0.991869219 0.002400185 FALSE TRUE
ENST00000534304 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding nonsense_mediated_decay 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.07602356 0.01425208 0.09296479 0.01425208 0.09296479 2.085971 0.05001667 0.06376667 0.04050000 -0.02326667 0.966120820 0.002400185 TRUE TRUE
ENST00000612359 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding protein_coding 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.29834946 0.19156898 0.47754865 0.09909799 0.05440433 1.274273 0.24600833 0.26656667 0.20316667 -0.06340000 0.768209252 0.002400185 FALSE TRUE
ENST00000619511 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding protein_coding 1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.13477036 0.00000000 0.11495141 0.00000000 0.11495141 3.643295 0.09507500 0.00000000 0.04956667 0.04956667 1.000000000 0.002400185 FALSE TRUE
MSTRG.18867.6 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding   1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.06879398 0.03695358 0.23543535 0.03695358 0.13526850 2.386036 0.05444583 0.03210000 0.09830000 0.06620000 0.933434893 0.002400185 TRUE TRUE
MSTRG.18867.9 ENSG00000174501 HEK293_OSMI2_6hA HEK293_TMG_6hB ANKRD36C protein_coding   1.412309 0.616736 2.34996 0.277013 0.04347479 1.912833 0.31727555 0.00000000 0.57695833 0.00000000 0.10879493 5.875186 0.17392083 0.00000000 0.24626667 0.24626667 0.002400185 0.002400185 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174501 E001 4.5785089 0.006701021 0.222279265 0.45620439 2 95836919 95837108 190 - 0.654 0.816 0.659
ENSG00000174501 E002 0.7366858 0.508984583 0.851266219   2 95849548 95850566 1019 - 0.216 0.182 -0.303
ENSG00000174501 E003 1.4287265 0.013039071 0.676611338 0.82060338 2 95851166 95851195 30 - 0.388 0.303 -0.519
ENSG00000174501 E004 3.5411533 0.007689308 0.098376502 0.27893134 2 95851694 95851787 94 - 0.541 0.781 1.027
ENSG00000174501 E005 0.4458772 0.021768165 0.170701092   2 95852126 95852196 71 - 0.081 0.303 2.289
ENSG00000174501 E006 1.4099455 0.012753540 0.677445938 0.82109956 2 95852290 95853708 1419 - 0.388 0.303 -0.518
ENSG00000174501 E007 4.6125568 0.016908303 0.076174204 0.23709485 2 95853709 95853861 153 - 0.634 0.877 0.984
ENSG00000174501 E008 15.9266662 0.002819745 0.050575795 0.18102163 2 95855266 95856007 742 - 1.133 1.294 0.568
ENSG00000174501 E009 5.1938411 0.007408896 0.008752602 0.05272881 2 95856008 95856180 173 - 0.613 0.958 1.383
ENSG00000174501 E010 4.1483760 0.007165808 0.042955953 0.16242408 2 95857309 95857457 149 - 0.566 0.849 1.174
ENSG00000174501 E011 2.5067644 0.023858372 0.369461392 0.60359425 2 95857458 95857492 35 - 0.457 0.606 0.705
ENSG00000174501 E012 5.0581419 0.008195227 0.966704277 0.98526986 2 95859861 95860074 214 - 0.744 0.744 -0.001
ENSG00000174501 E013 4.1691486 0.006567951 0.414112026 0.63906934 2 95867440 95867581 142 - 0.634 0.744 0.459
ENSG00000174501 E014 3.9995507 0.025549570 0.605728146 0.77402065 2 95876439 95876509 71 - 0.635 0.703 0.284
ENSG00000174501 E015 1.6647847 0.011922290 0.542527323 0.73089434 2 95876510 95876512 3 - 0.424 0.303 -0.711
ENSG00000174501 E016 4.5360750 0.008781927 0.339294655 0.57736664 2 95880427 95880499 73 - 0.655 0.782 0.523
ENSG00000174501 E017 2.6693638 0.009161765 0.802103678 0.89755309 2 95880595 95880623 29 - 0.515 0.547 0.152
ENSG00000174501 E018 2.4424994 0.009676551 0.171797558 0.39293476 2 95882302 95882374 73 - 0.567 0.303 -1.413
ENSG00000174501 E019 0.9452873 0.017267182 0.102994289   2 95882469 95882497 29 - 0.350 0.000 -12.994
ENSG00000174501 E020 3.0277166 0.009332517 0.148543505 0.36021339 2 95884173 95884245 73 - 0.486 0.703 0.969
ENSG00000174501 E021 3.0630658 0.021536694 0.150493420 0.36301356 2 95884340 95884368 29 - 0.487 0.703 0.968
ENSG00000174501 E022 3.9369644 0.010749430 0.274283391 0.51426023 2 95886048 95886120 73 - 0.591 0.745 0.653
ENSG00000174501 E023 3.2777542 0.010578377 0.430564624 0.65158688 2 95886216 95886244 29 - 0.542 0.657 0.515
ENSG00000174501 E024 3.2929875 0.117036758 0.876033150 0.93925392 2 95887925 95887997 73 - 0.611 0.554 -0.256
ENSG00000174501 E025 2.1449659 0.108424273 0.857283440 0.92897080 2 95888092 95888120 29 - 0.455 0.484 0.145
ENSG00000174501 E026 3.0261393 0.009078704 0.254321103 0.49277851 2 95889799 95889871 73 - 0.613 0.401 -1.033
ENSG00000174501 E027 2.2009491 0.034309509 0.287603891 0.52833312 2 95889966 95889994 29 - 0.517 0.303 -1.177
ENSG00000174501 E028 2.4450721 0.008781242 0.884768759 0.94378216 2 95891665 95891737 73 - 0.515 0.480 -0.169
ENSG00000174501 E029 1.3142389 0.014490699 0.846866524   2 95891832 95891860 29 - 0.350 0.303 -0.296
ENSG00000174501 E030 1.6101070 0.013564922 0.168220594 0.38819501 2 95893533 95893605 73 - 0.456 0.177 -1.883
ENSG00000174501 E031 1.6101070 0.013564922 0.168220594 0.38819501 2 95893696 95893724 29 - 0.456 0.177 -1.883
ENSG00000174501 E032 0.0000000       2 95894213 95894275 63 -      
ENSG00000174501 E033 0.9688700 0.016897986 0.533336231   2 95895399 95895471 73 - 0.308 0.177 -1.036
ENSG00000174501 E034 0.0000000       2 95895562 95895590 29 -      
ENSG00000174501 E035 0.1614157 0.045145936 1.000000000   2 95897270 95897342 73 - 0.081 0.000 -10.985
ENSG00000174501 E036 0.3040503 0.026040907 0.674805822   2 95897437 95897465 29 - 0.150 0.000 -11.814
ENSG00000174501 E037 0.4820342 0.021672648 0.389010439   2 95899145 95899217 73 - 0.209 0.000 -12.268
ENSG00000174501 E038 0.1779838 0.033609897 1.000000000   2 95899308 95899336 29 - 0.082 0.000 -10.991
ENSG00000174501 E039 0.0000000       2 95901015 95901087 73 -      
ENSG00000174501 E040 0.0000000       2 95901178 95901206 29 -      
ENSG00000174501 E041 0.7992560 0.189641457 0.726439466   2 95902886 95902958 73 - 0.261 0.178 -0.700
ENSG00000174501 E042 1.3219886 0.053994166 0.652596076   2 95903053 95903081 29 - 0.308 0.401 0.557
ENSG00000174501 E043 1.4999724 0.017012533 0.770652570 0.87904756 2 95904761 95904833 73 - 0.350 0.401 0.290
ENSG00000174501 E044 0.8565226 0.022114436 0.154689379   2 95904924 95904952 29 - 0.150 0.401 1.876
ENSG00000174501 E045 0.5061644 0.024683419 0.175776744   2 95905441 95905503 63 - 0.081 0.303 2.291
ENSG00000174501 E046 0.3393995 0.027442404 0.678076823   2 95906631 95906703 73 - 0.150 0.000 -11.815
ENSG00000174501 E047 0.3393995 0.027442404 0.678076823   2 95906794 95906822 29 - 0.150 0.000 -11.815
ENSG00000174501 E048 0.0000000       2 95906823 95907499 677 -      
ENSG00000174501 E049 0.3150090 0.027442404 0.490361015   2 95908502 95908574 73 - 0.081 0.177 1.292
ENSG00000174501 E050 0.6378404 0.032919334 1.000000000   2 95908669 95908697 29 - 0.209 0.177 -0.293
ENSG00000174501 E051 1.2914411 0.014082743 0.210959487   2 95910373 95910445 73 - 0.261 0.480 1.290
ENSG00000174501 E052 1.2914411 0.014082743 0.210959487   2 95910540 95910568 29 - 0.261 0.480 1.290
ENSG00000174501 E053 2.4278838 0.009773998 0.696274852 0.83315824 2 95912244 95912316 73 - 0.486 0.547 0.290
ENSG00000174501 E054 2.0831350 0.010320284 0.662382093 0.81136551 2 95912407 95912435 29 - 0.486 0.400 -0.448
ENSG00000174501 E055 3.2445158 0.029500953 0.377565718 0.61030320 2 95914108 95914180 73 - 0.634 0.481 -0.706
ENSG00000174501 E056 2.6642023 0.009402730 0.130708582 0.33289143 2 95914275 95914303 29 - 0.590 0.303 -1.519
ENSG00000174501 E057 3.2237822 0.007271767 0.007731132 0.04805725 2 95915980 95916052 73 - 0.692 0.177 -2.959
ENSG00000174501 E058 2.7361385 0.008587225 0.100127182 0.28203981 2 95916143 95916171 29 - 0.612 0.303 -1.617
ENSG00000174501 E059 2.7187625 0.008533196 0.646096635 0.80091440 2 95917855 95917927 73 - 0.566 0.480 -0.411
ENSG00000174501 E060 0.7555370 0.018417905 0.708073077   2 95918014 95918042 29 - 0.261 0.177 -0.712
ENSG00000174501 E061 0.9466924 0.016468474 0.796421933   2 95919733 95919805 73 - 0.261 0.303 0.288
ENSG00000174501 E062 0.7687085 0.020279405 0.584816272   2 95919892 95919920 29 - 0.209 0.303 0.704
ENSG00000174501 E063 1.3551249 0.015079741 0.595146495   2 95921607 95921679 73 - 0.308 0.401 0.553
ENSG00000174501 E064 1.3253852 0.013739288 0.826654552   2 95921782 95921810 29 - 0.350 0.303 -0.295
ENSG00000174501 E065 2.4783961 0.009676551 0.455479776 0.66987559 2 95923495 95923567 73 - 0.541 0.400 -0.711
ENSG00000174501 E066 1.8781178 0.056290503 0.464679253 0.67634496 2 95923661 95923689 29 - 0.459 0.304 -0.890
ENSG00000174501 E067 1.8919095 0.014431873 0.445971168 0.66270721 2 95925352 95925424 73 - 0.457 0.303 -0.882
ENSG00000174501 E068 1.2978584 0.013856659 0.291845829   2 95925519 95925547 29 - 0.388 0.177 -1.518
ENSG00000174501 E069 2.4564787 0.008697016 0.036047773 0.14436026 2 95927214 95927257 44 - 0.590 0.177 -2.519
ENSG00000174501 E070 2.4752597 0.009490319 0.036200799 0.14477338 2 95927258 95927286 29 - 0.590 0.177 -2.519
ENSG00000174501 E071 2.1712094 0.010864776 0.066861042 0.21800861 2 95927381 95927406 26 - 0.542 0.177 -2.298
ENSG00000174501 E072 1.8505909 0.017984635 0.124178507 0.32234210 2 95927407 95927409 3 - 0.487 0.177 -2.036
ENSG00000174501 E073 2.5157705 0.009963957 0.889659807 0.94651392 2 95929072 95929144 73 - 0.515 0.480 -0.171
ENSG00000174501 E074 0.8571428 0.017096868 0.578583577   2 95929239 95929267 29 - 0.209 0.303 0.707
ENSG00000174501 E075 3.0941314 0.007570087 0.204532800 0.43529512 2 95935454 95935526 73 - 0.634 0.400 -1.126
ENSG00000174501 E076 3.6049098 0.008133366 0.710364823 0.84201468 2 95935616 95935644 29 - 0.613 0.656 0.188
ENSG00000174501 E077 3.2113801 0.015947792 0.507567273 0.70606649 2 95938829 95938901 73 - 0.566 0.656 0.397
ENSG00000174501 E078 4.0571317 0.006138406 0.702349312 0.83705430 2 95938987 95939015 29 - 0.654 0.702 0.202
ENSG00000174501 E079 3.4803864 0.007327321 0.631583510 0.79142156 2 95941160 95941199 40 - 0.634 0.547 -0.387
ENSG00000174501 E080 3.2884231 0.007320811 0.879287900 0.94094635 2 95944627 95944694 68 - 0.590 0.605 0.068
ENSG00000174501 E081 3.4726839 0.007852125 0.219417053 0.45273110 2 95945114 95945174 61 - 0.566 0.743 0.757
ENSG00000174501 E082 3.9664845 0.006894492 0.705051169 0.83876914 2 95948530 95948596 67 - 0.654 0.702 0.201
ENSG00000174501 E083 3.3426235 0.007442752 0.994748442 0.99895431 2 95950749 95950779 31 - 0.612 0.605 -0.033
ENSG00000174501 E084 3.7233416 0.006541369 0.832971244 0.91546601 2 95951348 95951408 61 - 0.634 0.656 0.097
ENSG00000174501 E085 3.0046520 0.019189585 0.220149763 0.45371407 2 95953939 95954005 67 - 0.633 0.400 -1.122
ENSG00000174501 E086 1.9942758 0.211794323 0.511887074 0.70941330 2 95956786 95956816 31 - 0.508 0.303 -1.135
ENSG00000174501 E087 4.9349296 0.057045228 0.908402964 0.95636095 2 95958591 95958663 73 - 0.758 0.702 -0.226
ENSG00000174501 E088 4.5048128 0.111936378 0.780912257 0.88524963 2 95958757 95958785 29 - 0.710 0.703 -0.029
ENSG00000174501 E089 2.3474105 0.065742020 0.514963997 0.71163955 2 95960473 95960545 73 - 0.540 0.400 -0.705
ENSG00000174501 E090 0.7791197 0.203815578 0.580177964   2 95960639 95960667 29 - 0.212 0.297 0.648
ENSG00000174501 E091 1.9374797 0.011315070 0.334781521 0.57337531 2 95962352 95962424 73 - 0.388 0.547 0.802
ENSG00000174501 E092 2.4879833 0.009629175 0.348684747 0.58613690 2 95962519 95962547 29 - 0.456 0.605 0.705
ENSG00000174501 E093 1.8038351 0.011377323 0.573122955 0.75240968 2 95978122 95978189 68 - 0.388 0.480 0.483
ENSG00000174501 E094 4.8526542 0.019288192 0.018747917 0.09154454 2 95980648 95980785 138 - 0.818 0.401 -1.877
ENSG00000174501 E095 3.5769734 0.007250147 0.004292333 0.03079630 2 95982256 95982362 107 - 0.727 0.177 -3.103
ENSG00000174501 E096 0.1426347 0.038242126 1.000000000   2 95986623 95986750 128 - 0.081 0.000 -10.987
ENSG00000174501 E097 3.9948422 0.065809835 0.034503323 0.14020860 2 95986751 95986924 174 - 0.758 0.304 -2.218
ENSG00000174501 E098 3.5868192 0.239214767 0.949691832 0.97691820 2 95987092 95987206 115 - 0.650 0.598 -0.225
ENSG00000174501 E099 6.2224265 0.005789228 0.737762515 0.85910916 2 95991512 95991831 320 - 0.818 0.848 0.119