ENSG00000174442

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307897 ENSG00000174442 HEK293_OSMI2_6hA HEK293_TMG_6hB ZWILCH protein_coding protein_coding 19.5625 5.232348 28.67557 0.5715394 1.31375 2.45204 11.294400 4.2650739 16.114475 0.4063711 0.7690462 1.915231 0.67105000 0.8187333 0.56470000 -0.25403333 7.718425e-03 5.991033e-12 FALSE TRUE
ENST00000446801 ENSG00000174442 HEK293_OSMI2_6hA HEK293_TMG_6hB ZWILCH protein_coding protein_coding 19.5625 5.232348 28.67557 0.5715394 1.31375 2.45204 1.521465 0.5330143 2.239874 0.1839466 0.2418139 2.050782 0.07178750 0.1014667 0.07823333 -0.02323333 9.170550e-01 5.991033e-12 FALSE TRUE
ENST00000564179 ENSG00000174442 HEK293_OSMI2_6hA HEK293_TMG_6hB ZWILCH protein_coding protein_coding 19.5625 5.232348 28.67557 0.5715394 1.31375 2.45204 2.056289 0.0000000 2.495221 0.0000000 0.3140023 7.968794 0.06162917 0.0000000 0.08676667 0.08676667 2.730539e-08 5.991033e-12 FALSE FALSE
ENST00000565627 ENSG00000174442 HEK293_OSMI2_6hA HEK293_TMG_6hB ZWILCH protein_coding protein_coding 19.5625 5.232348 28.67557 0.5715394 1.31375 2.45204 3.016621 0.0000000 5.589672 0.0000000 0.7975934 9.129199 0.09214583 0.0000000 0.19443333 0.19443333 5.991033e-12 5.991033e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174442 E001 0.1779838 0.0405295551 1.000000000   15 66504959 66505082 124 + 0.065 0.000 -9.011
ENSG00000174442 E002 0.1614157 0.0329810205 1.000000000   15 66505083 66505116 34 + 0.065 0.000 -9.000
ENSG00000174442 E003 6.6338737 0.2391085853 0.232382307 0.46796317 15 66505117 66505294 178 + 0.726 1.027 1.156
ENSG00000174442 E004 4.5312672 0.3152104512 0.096695768 0.27595833 15 66505295 66505299 5 + 0.539 0.978 1.791
ENSG00000174442 E005 13.0804156 0.5556119994 0.402900842 0.63068193 15 66505300 66505325 26 + 1.011 1.218 0.746
ENSG00000174442 E006 33.6026191 0.7857963111 0.417542627 0.64175091 15 66505326 66505391 66 + 1.404 1.589 0.636
ENSG00000174442 E007 0.5955263 0.0193874923 0.024897750   15 66505392 66505400 9 + 0.065 0.468 3.587
ENSG00000174442 E008 3.7082717 0.0089976562 0.557671172 0.74161072 15 66508746 66508840 95 + 0.625 0.554 -0.314
ENSG00000174442 E009 49.3855815 0.0693136571 0.583011434 0.75903164 15 66508841 66508892 52 + 1.592 1.685 0.316
ENSG00000174442 E010 0.1723744 0.0343379371 0.120148960   15 66513934 66513987 54 + 0.000 0.217 12.977
ENSG00000174442 E011 83.9031988 0.0062006640 0.539606843 0.72872885 15 66513988 66514083 96 + 1.839 1.841 0.008
ENSG00000174442 E012 0.2027342 0.0422398828 0.120415404   15 66514327 66514522 196 + 0.000 0.217 12.980
ENSG00000174442 E013 116.9645018 0.0003686032 0.003076039 0.02387051 15 66515526 66515644 119 + 1.996 1.919 -0.256
ENSG00000174442 E014 58.7688455 0.0007814351 0.006468691 0.04203140 15 66518879 66518882 4 + 1.708 1.592 -0.393
ENSG00000174442 E015 102.4378061 0.0017378514 0.003377153 0.02562523 15 66518883 66518969 87 + 1.942 1.849 -0.311
ENSG00000174442 E016 109.9689081 0.0061764301 0.136233764 0.34172737 15 66518970 66519078 109 + 1.961 1.927 -0.114
ENSG00000174442 E017 0.9500890 0.1250390117 0.781919491   15 66519079 66519129 51 + 0.257 0.215 -0.335
ENSG00000174442 E018 0.4820342 0.0214773313 0.550234372   15 66520508 66520589 82 + 0.171 0.000 -10.585
ENSG00000174442 E019 88.5022345 0.0066166256 0.024852672 0.11178202 15 66520590 66520660 71 + 1.877 1.789 -0.298
ENSG00000174442 E020 0.0000000       15 66520661 66520664 4 +      
ENSG00000174442 E021 137.5065207 0.0048277924 0.058858724 0.20018355 15 66521050 66521205 156 + 2.058 2.012 -0.153
ENSG00000174442 E022 0.6544085 0.0190003349 0.874711834   15 66523511 66523676 166 + 0.171 0.217 0.421
ENSG00000174442 E023 96.0551875 0.0005581874 0.104141376 0.28906070 15 66523677 66523748 72 + 1.901 1.873 -0.093
ENSG00000174442 E024 94.6303201 0.0004483572 0.700742282 0.83613555 15 66527290 66527383 94 + 1.885 1.913 0.094
ENSG00000174442 E025 87.1251548 0.0004759327 0.064052896 0.21178410 15 66527857 66527912 56 + 1.863 1.821 -0.141
ENSG00000174442 E026 99.7076574 0.0068617422 0.136056729 0.34142450 15 66528852 66528957 106 + 1.917 1.874 -0.144
ENSG00000174442 E027 93.4856452 0.0036406083 0.018742107 0.09152933 15 66529494 66529573 80 + 1.897 1.817 -0.271
ENSG00000174442 E028 124.0524177 0.0009220491 0.805503388 0.89938377 15 66532247 66532403 157 + 1.998 2.034 0.120
ENSG00000174442 E029 66.5097836 0.0012998355 0.673694430 0.81874385 15 66532985 66533013 29 + 1.723 1.790 0.228
ENSG00000174442 E030 133.8043393 0.0026114180 0.853969129 0.92708904 15 66535933 66536069 137 + 2.030 2.070 0.134
ENSG00000174442 E031 65.0041979 0.0225703045 0.691286203 0.82988454 15 66537168 66537168 1 + 1.725 1.745 0.068
ENSG00000174442 E032 127.3911900 0.0063386359 0.996883243 1.00000000 15 66537169 66537263 95 + 2.007 2.056 0.164
ENSG00000174442 E033 107.6961762 0.0004749671 0.492136130 0.69543668 15 66540098 66540152 55 + 1.942 1.958 0.056
ENSG00000174442 E034 94.2399961 0.0004367722 0.924879364 0.96477757 15 66540153 66540210 58 + 1.878 1.926 0.162
ENSG00000174442 E035 107.9523311 0.0321395743 0.126872946 0.32680616 15 66546591 66546705 115 + 1.907 2.069 0.544
ENSG00000174442 E036 2.1418296 0.0101839914 0.574686788 0.75345506 15 66546706 66546887 182 + 0.443 0.361 -0.453
ENSG00000174442 E037 0.7193800 0.0279610003 0.069814552   15 66547243 66547292 50 + 0.121 0.467 2.589
ENSG00000174442 E038 367.4947462 0.0218184421 0.001177159 0.01125548 15 66548351 66550130 1780 + 2.413 2.650 0.787