ENSG00000174437

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000539276 ENSG00000174437 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2A2 protein_coding protein_coding 105.2456 84.25848 143.2339 14.49947 4.385795 0.765409 18.12109 16.60689 16.69929 2.378644 0.432183 0.007999728 0.1830750 0.1997333 0.1167333 -0.08300000 7.301905e-05 7.301905e-05 FALSE TRUE
ENST00000548169 ENSG00000174437 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2A2 protein_coding protein_coding 105.2456 84.25848 143.2339 14.49947 4.385795 0.765409 53.35899 45.33233 73.60415 9.363617 2.840321 0.699124732 0.5130000 0.5297000 0.5136000 -0.01610000 9.388812e-01 7.301905e-05 FALSE TRUE
MSTRG.8001.6 ENSG00000174437 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP2A2 protein_coding   105.2456 84.25848 143.2339 14.49947 4.385795 0.765409 22.40838 18.51849 44.04215 3.550623 1.468699 1.249466783 0.2108458 0.2181000 0.3076667 0.08956667 7.496233e-03 7.301905e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174437 E001 0.6002783 5.015564e-01 7.636815e-01   12 110280756 110280964 209 + 0.250 0.144 -0.984
ENSG00000174437 E002 5.8675382 5.108971e-03 2.715094e-01 5.113772e-01 12 110281116 110281246 131 + 0.766 0.922 0.604
ENSG00000174437 E003 34.0859071 2.533225e-02 9.476545e-06 2.001412e-04 12 110281247 110281296 50 + 1.291 1.757 1.598
ENSG00000174437 E004 63.6808028 8.804425e-03 4.332076e-09 2.202653e-07 12 110281297 110281501 205 + 1.600 1.997 1.341
ENSG00000174437 E005 510.5937101 2.082710e-03 6.575642e-02 2.156365e-01 12 110281502 110281907 406 + 2.674 2.741 0.225
ENSG00000174437 E006 0.0000000       12 110281908 110281918 11 +      
ENSG00000174437 E007 281.0476979 1.706484e-04 1.311794e-02 7.093770e-02 12 110282604 110282621 18 + 2.460 2.424 -0.121
ENSG00000174437 E008 453.9807607 1.676387e-04 8.013088e-08 3.044991e-06 12 110282713 110282795 83 + 2.682 2.604 -0.258
ENSG00000174437 E009 367.9632800 4.161486e-04 1.215471e-07 4.420968e-06 12 110292020 110292048 29 + 2.596 2.501 -0.316
ENSG00000174437 E010 527.6916603 8.340134e-04 6.371579e-06 1.422241e-04 12 110292049 110292124 76 + 2.747 2.668 -0.264
ENSG00000174437 E011 0.6182515 6.239317e-02 1.925626e-01   12 110295991 110296314 324 + 0.103 0.335 2.115
ENSG00000174437 E012 870.1915380 8.834956e-05 2.781859e-18 6.632449e-16 12 110296599 110296737 139 + 2.972 2.878 -0.311
ENSG00000174437 E013 855.6462310 1.216929e-03 4.242337e-11 3.249646e-09 12 110322992 110323072 81 + 2.975 2.852 -0.410
ENSG00000174437 E014 8.5369649 2.790455e-01 5.426742e-01 7.309937e-01 12 110325801 110326389 589 + 0.999 0.923 -0.284
ENSG00000174437 E015 892.0992804 5.355545e-04 2.522852e-17 5.180344e-15 12 110326390 110326475 86 + 2.993 2.871 -0.406
ENSG00000174437 E016 1019.1696568 2.694669e-04 6.551446e-15 9.863354e-13 12 110327553 110327686 134 + 3.039 2.950 -0.295
ENSG00000174437 E017 1341.9028453 7.775907e-05 6.066605e-12 5.445291e-10 12 110327687 110328017 331 + 3.144 3.091 -0.177
ENSG00000174437 E018 3.4547107 3.068445e-02 3.879349e-01 6.188788e-01 12 110329399 110331971 2573 + 0.701 0.569 -0.573
ENSG00000174437 E019 3.5329711 1.502849e-01 8.972643e-01 9.504379e-01 12 110331972 110332596 625 + 0.655 0.650 -0.018
ENSG00000174437 E020 714.9240868 9.807051e-05 1.513691e-09 8.540184e-08 12 110332597 110332685 89 + 2.876 2.809 -0.221
ENSG00000174437 E021 857.1722127 8.777886e-05 4.535452e-23 1.883188e-20 12 110333181 110333283 103 + 2.971 2.861 -0.365
ENSG00000174437 E022 1135.6084022 1.138493e-04 3.179097e-18 7.498385e-16 12 110334012 110334143 132 + 3.083 3.001 -0.275
ENSG00000174437 E023 3.1818281 7.919728e-03 1.233280e-01 3.210389e-01 12 110334144 110334291 148 + 0.701 0.468 -1.055
ENSG00000174437 E024 934.7342673 4.665803e-04 2.336683e-03 1.929413e-02 12 110339281 110339403 123 + 2.977 2.947 -0.099
ENSG00000174437 E025 1217.0802908 8.893655e-05 2.497017e-02 1.121324e-01 12 110339503 110339721 219 + 3.083 3.077 -0.021
ENSG00000174437 E026 1515.4087298 7.247218e-05 2.035540e-05 3.877527e-04 12 110340659 110340994 336 + 3.151 3.210 0.197
ENSG00000174437 E027 1229.2362669 8.554521e-05 3.426628e-08 1.421051e-06 12 110342228 110342448 221 + 3.052 3.129 0.257
ENSG00000174437 E028 552.9135367 1.695957e-04 4.828858e-07 1.501650e-05 12 110343232 110343255 24 + 2.695 2.793 0.328
ENSG00000174437 E029 989.1469044 7.371227e-05 5.312806e-08 2.106632e-06 12 110343256 110343434 179 + 2.955 3.037 0.272
ENSG00000174437 E030 592.8412427 2.522416e-04 9.292939e-03 5.506088e-02 12 110344886 110344971 86 + 2.742 2.803 0.202
ENSG00000174437 E031 10.7580529 1.571421e-01 4.882137e-01 6.928038e-01 12 110344972 110345247 276 + 1.101 1.003 -0.357
ENSG00000174437 E032 919.6158069 9.714880e-04 7.648882e-02 2.377212e-01 12 110345249 110345382 134 + 2.937 2.989 0.175
ENSG00000174437 E033 48.2164068 1.541255e-01 4.635530e-01 6.755224e-01 12 110345437 110346000 564 + 1.716 1.640 -0.256
ENSG00000174437 E034 1126.7920327 9.282131e-05 8.134598e-04 8.391701e-03 12 110346001 110346118 118 + 3.023 3.079 0.186
ENSG00000174437 E035 1299.6013243 8.952790e-05 2.118587e-01 4.439158e-01 12 110346201 110346321 121 + 3.095 3.126 0.103
ENSG00000174437 E036 2794.0786616 1.800631e-03 2.172997e-03 1.822435e-02 12 110346322 110347392 1071 + 3.405 3.485 0.266
ENSG00000174437 E037 93.1516946 7.699490e-04 7.542857e-01 8.692801e-01 12 110347393 110347453 61 + 1.963 1.968 0.017
ENSG00000174437 E038 212.1730966 5.771770e-03 9.483687e-02 2.726831e-01 12 110347454 110347791 338 + 2.285 2.370 0.283
ENSG00000174437 E039 1263.4871944 4.671440e-03 3.680160e-11 2.849867e-09 12 110347792 110350291 2500 + 2.983 3.217 0.779
ENSG00000174437 E040 451.9300842 1.146783e-03 1.438050e-35 1.795692e-32 12 110350292 110351146 855 + 2.494 2.801 1.024