ENSG00000174373

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000389698 ENSG00000174373 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA1 protein_coding protein_coding 8.06302 3.382404 15.4251 0.8623424 0.8038552 2.185835 2.9809953 0.7886479 6.3860954 0.1453002 0.41588046 3.001560 0.31047500 0.2478 0.41403333 0.16623333 0.04817625 0.04817625 FALSE TRUE
ENST00000553917 ENSG00000174373 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA1 protein_coding retained_intron 8.06302 3.382404 15.4251 0.8623424 0.8038552 2.185835 0.3647219 0.0000000 0.9063905 0.0000000 0.45654228 6.517891 0.02624167 0.0000 0.06183333 0.06183333 0.55388661 0.04817625 FALSE TRUE
ENST00000554573 ENSG00000174373 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA1 protein_coding protein_coding 8.06302 3.382404 15.4251 0.8623424 0.8038552 2.185835 0.9825792 1.3063048 0.6430331 0.4043070 0.39820691 -1.011266 0.27335000 0.3688 0.03923333 -0.32956667 0.07985639 0.04817625 FALSE TRUE
ENST00000637992 ENSG00000174373 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA1 protein_coding protein_coding 8.06302 3.382404 15.4251 0.8623424 0.8038552 2.185835 0.8363285 0.2401207 1.7500342 0.1382793 0.05590684 2.814907 0.07452500 0.0871 0.11370000 0.02660000 0.84679664 0.04817625 FALSE TRUE
MSTRG.9385.9 ENSG00000174373 HEK293_OSMI2_6hA HEK293_TMG_6hB RALGAPA1 protein_coding   8.06302 3.382404 15.4251 0.8623424 0.8038552 2.185835 1.2955662 0.2130476 2.9413690 0.1246061 0.03004594 3.725961 0.11362500 0.0765 0.19186667 0.11536667 0.58653507 0.04817625 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000174373 E001 0.0000000       14 35538352 35538355 4 -      
ENSG00000174373 E002 0.0000000       14 35538356 35538356 1 -      
ENSG00000174373 E003 40.8511374 0.7576772565 0.1721535824 0.393398543 14 35538357 35539068 712 - 1.370 1.862 1.677
ENSG00000174373 E004 4.3957491 0.1545666105 0.0014570185 0.013317498 14 35539069 35539159 91 - 0.387 1.123 3.094
ENSG00000174373 E005 23.2248792 0.5636907311 0.1137686424 0.305419500 14 35539160 35539339 180 - 1.125 1.642 1.798
ENSG00000174373 E006 15.9301160 0.4795584975 0.1797376232 0.403612281 14 35539340 35539389 50 - 1.019 1.410 1.385
ENSG00000174373 E007 15.3427739 0.5299545804 0.3881128114 0.619023076 14 35539390 35539438 49 - 1.051 1.296 0.874
ENSG00000174373 E008 44.0651999 0.8067897005 0.2828683661 0.523306033 14 35539439 35539634 196 - 1.461 1.786 1.105
ENSG00000174373 E009 36.2092203 0.3899628222 0.1125816764 0.303461074 14 35539635 35539690 56 - 1.358 1.748 1.334
ENSG00000174373 E010 3.3226817 0.0076197034 0.2084721128 0.440028333 14 35541740 35541804 65 - 0.579 0.383 -0.980
ENSG00000174373 E011 1.4945058 0.0125760840 0.9978696428 1.000000000 14 35542027 35542029 3 - 0.338 0.382 0.264
ENSG00000174373 E012 6.2750360 0.0052056698 0.4762971450 0.684461157 14 35542030 35542524 495 - 0.768 0.720 -0.195
ENSG00000174373 E013 22.9031343 0.2433621417 0.1232073513 0.320832955 14 35548508 35548511 4 - 1.179 1.539 1.254
ENSG00000174373 E014 26.3577293 0.1381331577 0.1202127890 0.316183330 14 35548512 35548538 27 - 1.253 1.563 1.073
ENSG00000174373 E015 24.0766069 0.0886391785 0.1418584181 0.350249863 14 35549110 35549173 64 - 1.229 1.500 0.944
ENSG00000174373 E016 21.1326105 0.0027498622 0.0338335545 0.138417431 14 35549174 35549234 61 - 1.183 1.434 0.877
ENSG00000174373 E017 0.5061644 0.6094816665 0.1813603087   14 35564373 35564517 145 - 0.060 0.389 3.293
ENSG00000174373 E018 31.2215880 0.0012697678 0.2671648159 0.506798337 14 35570617 35570744 128 - 1.363 1.516 0.530
ENSG00000174373 E019 56.6436319 0.0164493462 0.8364895540 0.917532702 14 35572560 35572718 159 - 1.624 1.722 0.335
ENSG00000174373 E020 0.3807181 0.0458962194 0.3083545010   14 35572719 35572860 142 - 0.060 0.233 2.268
ENSG00000174373 E021 64.7832918 0.0062792704 0.1332983076 0.336972201 14 35595634 35595789 156 - 1.667 1.841 0.590
ENSG00000174373 E022 49.5096028 0.0009011917 0.0536090066 0.188131144 14 35605586 35605709 124 - 1.553 1.738 0.631
ENSG00000174373 E023 21.1959859 0.0151164505 0.0577131967 0.197678003 14 35625361 35625432 72 - 1.186 1.441 0.894
ENSG00000174373 E024 86.2561046 0.2503461413 0.2587014961 0.497530822 14 35627090 35627951 862 - 1.777 1.996 0.737
ENSG00000174373 E025 39.9645164 0.0059390863 0.8956209565 0.949532327 14 35634574 35634757 184 - 1.491 1.574 0.284
ENSG00000174373 E026 36.0494953 0.0087035293 0.6881284302 0.827925542 14 35635464 35635598 135 - 1.439 1.542 0.355
ENSG00000174373 E027 37.7501953 0.0178062619 0.9319099697 0.968078184 14 35651805 35651873 69 - 1.460 1.542 0.281
ENSG00000174373 E028 38.5775275 0.0087356784 0.8080410952 0.901060898 14 35654367 35654477 111 - 1.474 1.526 0.178
ENSG00000174373 E029 25.9511512 0.0017385652 0.1606965972 0.377820549 14 35655807 35655915 109 - 1.325 1.272 -0.187
ENSG00000174373 E030 19.9657331 0.0098565672 0.7859526480 0.888070376 14 35659138 35659196 59 - 1.200 1.239 0.136
ENSG00000174373 E031 21.0699494 0.0239098810 0.9858305266 0.994741585 14 35664642 35664767 126 - 1.216 1.277 0.215
ENSG00000174373 E032 20.9757228 0.0020296415 0.5313232043 0.722990051 14 35671389 35671517 129 - 1.204 1.333 0.451
ENSG00000174373 E033 31.5778060 0.0301796456 0.4943185448 0.696941953 14 35672867 35673022 156 - 1.399 1.404 0.020
ENSG00000174373 E034 26.4287224 0.0251400503 0.0606156567 0.204211780 14 35674180 35674223 44 - 1.348 1.213 -0.472
ENSG00000174373 E035 27.2052508 0.0214055915 0.1305782879 0.332714400 14 35674224 35674278 55 - 1.355 1.266 -0.314
ENSG00000174373 E036 38.1649656 0.0012590845 0.0041054745 0.029758163 14 35674516 35674709 194 - 1.508 1.360 -0.510
ENSG00000174373 E037 1.3989868 0.0121372860 0.4951447667 0.697585612 14 35676229 35677949 1721 - 0.338 0.232 -0.736
ENSG00000174373 E038 40.1750702 0.0010720068 0.0070314610 0.044786381 14 35677950 35678102 153 - 1.525 1.398 -0.436
ENSG00000174373 E039 0.0000000       14 35683446 35683808 363 -      
ENSG00000174373 E040 40.5483029 0.0038344761 0.0432859528 0.163310903 14 35683809 35683985 177 - 1.517 1.434 -0.287
ENSG00000174373 E041 43.3264116 0.0177586588 0.0200261542 0.095968853 14 35684929 35685145 217 - 1.555 1.398 -0.541
ENSG00000174373 E042 28.3404135 0.0067286686 0.0133346234 0.071791705 14 35686542 35686623 82 - 1.380 1.218 -0.565
ENSG00000174373 E043 22.9501964 0.0385714522 0.2977157925 0.538206181 14 35686624 35686666 43 - 1.274 1.204 -0.245
ENSG00000174373 E044 8.6399058 0.0182486718 0.3473920790 0.584862993 14 35688459 35688540 82 - 0.839 1.036 0.740
ENSG00000174373 E045 39.9463184 0.0165592279 0.3987696805 0.627252336 14 35688541 35689533 993 - 1.466 1.620 0.526
ENSG00000174373 E046 16.2684404 0.0218929009 0.6288038563 0.789722327 14 35689534 35689835 302 - 1.123 1.137 0.049
ENSG00000174373 E047 43.5299891 0.0111614439 0.0042931804 0.030799289 14 35689836 35690003 168 - 1.559 1.374 -0.637
ENSG00000174373 E048 1.1019510 0.1549371629 0.6804702434   14 35700162 35700302 141 - 0.242 0.378 0.898
ENSG00000174373 E049 4.4999427 0.0092755846 0.3227237324 0.562097529 14 35706634 35707583 950 - 0.611 0.823 0.872
ENSG00000174373 E050 21.7144167 0.0017917305 0.1806080737 0.404732059 14 35721688 35721849 162 - 1.257 1.200 -0.201
ENSG00000174373 E051 37.0294962 0.0172194754 0.0012293444 0.011647565 14 35723027 35723264 238 - 1.500 1.237 -0.911
ENSG00000174373 E052 0.6434498 0.0195718614 0.4431740537   14 35723265 35723876 612 - 0.201 0.000 -9.231
ENSG00000174373 E053 32.1746833 0.0062370969 0.0008777968 0.008912477 14 35725024 35725153 130 - 1.439 1.200 -0.837
ENSG00000174373 E054 0.0000000       14 35728341 35728361 21 -      
ENSG00000174373 E055 29.2257033 0.0092824591 0.0297897257 0.126717917 14 35728362 35728510 149 - 1.388 1.254 -0.467
ENSG00000174373 E056 21.3795113 0.0016878991 0.1473811251 0.358562022 14 35738513 35738650 138 - 1.250 1.180 -0.246
ENSG00000174373 E057 16.9090481 0.0023263083 0.2355827794 0.471495950 14 35742368 35742565 198 - 1.149 1.091 -0.210
ENSG00000174373 E058 0.0000000       14 35748400 35748584 185 -      
ENSG00000174373 E059 27.8682929 0.0049353219 0.0272710644 0.119095037 14 35748585 35748791 207 - 1.368 1.237 -0.460
ENSG00000174373 E060 22.9002724 0.0065166055 0.0528634718 0.186393019 14 35748792 35748824 33 - 1.285 1.159 -0.443
ENSG00000174373 E061 38.4097311 0.0225188904 0.1089310250 0.297280228 14 35750482 35750690 209 - 1.496 1.416 -0.275
ENSG00000174373 E062 26.9261256 0.0132997470 0.2198876552 0.453382966 14 35752024 35752162 139 - 1.341 1.300 -0.143
ENSG00000174373 E063 31.1721925 0.0077827352 0.0825527550 0.249819247 14 35756793 35756908 116 - 1.406 1.319 -0.302
ENSG00000174373 E064 44.2194823 0.0009548489 0.0279147984 0.121028742 14 35760829 35761006 178 - 1.556 1.477 -0.272
ENSG00000174373 E065 23.4131144 0.0018126181 0.0702933802 0.225344556 14 35762710 35762753 44 - 1.297 1.200 -0.344
ENSG00000174373 E066 23.1667625 0.0015837545 0.0506372928 0.181187305 14 35770942 35770999 58 - 1.294 1.180 -0.402
ENSG00000174373 E067 20.8021300 0.0018834359 0.0048314310 0.033699762 14 35775006 35775055 50 - 1.264 1.037 -0.811
ENSG00000174373 E068 27.9049495 0.0012773896 0.0027642584 0.021957746 14 35775635 35775745 111 - 1.382 1.180 -0.707
ENSG00000174373 E069 0.9121510 0.0190249962 0.2349867001   14 35807805 35807897 93 - 0.274 0.000 -9.813
ENSG00000174373 E070 37.3748641 0.0076210964 0.1637306788 0.382260343 14 35808730 35809304 575 - 1.480 1.434 -0.159